A5045098110- Traumatic Brain Injury and Neurovascular Disturbances
- Traumatic Brain Injury Research
- Thermal Regulation in Medicine
- Neonatal and fetal brain pathology
- S100 Proteins and Annexins
- Cardiac Arrest and Resuscitation
- Neurological Disorders and Treatments
- Sepsis Diagnosis and Treatment
- Mitochondrial Function and Pathology
- Electrospun Nanofibers in Biomedical Applications
- Trauma and Emergency Care Studies
- Micro and Nano Robotics
- Mesenchymal stem cell research
- Bone Tissue Engineering Materials
- Neurological Disease Mechanisms and Treatments
- Acute Ischemic Stroke Management
- Antenna Design and Optimization
- Nerve injury and regeneration
- Acupuncture Treatment Research Studies
- Nanoparticle-Based Drug Delivery
- 3D Printing in Biomedical Research
- Radio Wave Propagation Studies
- Aerospace Engineering and Energy Systems
- Tissue Engineering and Regenerative Medicine
- Photoreceptor and optogenetics research
Tianjin Economic-Technological Development Area
2022-2024
Tianjin University
2022
Hefei Cement Research Design Institute
2022
Chinese People's Armed Police Force
2012-2020
Pingjin Hospital
2012-2018
Logistics University of People's Armed Police Force
2016-2017
Tianjin University of Traditional Chinese Medicine
2016
Chinese People's Armed Police Force Medical College Affiliated Hospital
2012
As a transdermal drug delivery method, microneedles offer minimal invasiveness, painlessness, and precise in-situ treatment. However, current rely on passive diffusion, leading to uncontrollable penetration. To overcome this, we developed pneumatic microneedle patch that uses live Enterobacter aerogenes as microengines actively control delivery. These microbes generate gas, driving drugs into deeper tissues, with adjustable glucose concentration allowing over the process. Our results showed...
Spinal cord organoids are of significant value in the research spinal cord-related diseases by simulating disease states, thereby facilitating development novel therapies. However, complexity structure and physiological functions, along with lack human-derived inducing components, presents challenges vitro construction human organoids. Here, we introduce a decellularized placenta-derived extracellular matrix hydrogel (DPECMH) and, combined new induction protocol, successfully construct The...
Spinal cord injuries (SCI) often cause severe inflammatory response and neuronal loss, which consequently deteriorates motor function. Although exogenous stem cells are considered to be vital seed for cell replacement therapy after SCI, their low survival rate efficiency of differentiation in vivo transplantation limit widespread application clinical practice. To this end, study proposed a new strategy dramatically improving the insulin-like growth factor 1 (IGF1c) mimetic peptide activate...
Stem cell transplantation holds great potential for the treatment of traumatic brain injury (TBI). However, micro-environment reduced oxygen and accumulated toxins leads to low survival rates grafted cells, which dramatically limits their clinical application. Mild hypothermia has been demonstrated improve after severe TBI. Thus, we speculate that combinational therapy mild may promote especially temperature-sensitive stem show most activity in temperatures. In this study, first isolated...
Aim: To investigate the protective effect of hypothermia (HT) on brain injury in moderate traumatic (TBI) rat models and potential mechanisms, especially involvement RIPK1 apoptosis necroptosis.Methods: Adult Sprague-Dawley rats were randomized to four groups: sham+normothermia (sham+NT), sham+hypothermia (sham+HT), TBI+normothermia (TBI+NT) TBI+hypothermia (TBI+HT). The sham+HT TBI+HT groups submitted 32°C for 6 hours. regional cerebral blood flow (rCBF) was assessed 24 hours after TBI; 48...
The microorganism has become a promising therapeutic tool for many diseases because it is kind of cell factory that can efficiently synthesize variety bioactive substances. However, the metabolic destiny microorganisms difficult to predict in vivo. Here, timing bionic dormant body with programmable reported, which time and location vivo prevent from being damaged by complex biological environment Taking digestive system as an example, exists upper tract nonmetabolic after oral administration...
Brain trauma or traumatic brain injury (TBI) is one of the leading causes death and disability worldwide. Along with conventional therapeutic strategies, neurorestorative treatments for TBI have been developed in recent decades. However, missing standards guidelines has become a growing issue both clinical practice fundamental research. Consequently, Chinese Association Neurorestoratology (Preparatory; CANR) China Committee International (IANR-China Committee) reached consensus to form...
Traumatic brain injury (TBI) contributes to hypocoagulopathy associated with prolonged bleeding and hemorrhagic progression. Bloodletting puncture therapy at hand twelve Jing-well points (BL-HTWP) have been applied as a first aid measure in various of emergent neurological diseases, but the detailed mechanisms modulation between central nervous system systemic circulation after acute TBI rodents remain unclear. To investigate whether BL-HTWP stimulation modulates hypocoagulable state exerts...
Bloodletting at Jing points has been used to treat coma in traditional Chinese medicine. Mild induced hypothermia also shown have neuroprotective effects. However, the therapeutic effects of bloodletting and mild alone are limited. Therefore, we investigated whether combined treatment might clinical effectiveness for acute severe traumatic brain injury. Using a rat model injury, substantially alleviated cerebral edema blood-brain barrier dysfunction. Furthermore, neurological function was...
Previous studies have reported that mild induced hypothermia (MIH) treatment has positive effects on traumatic brain injury (TBI) outcomes, which recently been linked to β-amyloid (Aβ)-induced secondary (SBI) extent in hippocampal tissues. We therefore investigate the relationship between MIH and expression of Aβ related proteins following TBI. Adult Sprague-Dawley rats were randomly divided into three equal groups (S: sham-operated, N: normothermia, H: hypothermia). After TBI by fluid...
An accurate and effective neurological evaluation is indispensable in the treatment rehabilitation of traumatic brain injury. However, most existing methods basic research clinical practice are not objective or intuitive for assessing function big animals, also difficult to use qualify extent damage recovery. In present study, we established a animal model injury by impacting cortical motor region beagles. At 2 weeks after successful modeling, detected deficiencies using series techniques,...
To observe the effect of bloodletting acupuncture at twelve jing-well points hand on microcirculatory disturbance in mice with traumatic brain injury (TBI), and to explore protective therapy TBI.Sixty clean adult male C57BL/6J were randomly divided into a sham-operation group, model group treatment 20 each group. The TBI was established by using electronic controlled cerebral cortex impact instrument treated bilateral "Shaoshang" (LU 11), "Shangyang" (LI 1), "Zhongchong" (PC 9), "Guanchong"...
Objective To establish the electric controlled cortical impact (eCCI)-induced traumatic brain injury (TBI) model in rats with different severity degree, which may serve as a suitable platform to provide experimental evidence for pathophysiological following TBI. Methods A total of 40 male Wistar were randomly divided into 3 groups and sham group. TBI (n=10/group) positioned beneath impactor device (eCCI) subjected at 2 mm depth penetration, sustained depression 200 ms, 4 m/s, 5 6 m/s...
Objective To investigate the effects of regulated necrosis induced by receptor interacting- protein 3 (RIP3) on traumatic brain injury (TBI) and its mechanisms in vitro vivo. Methods HT-22 cell lines were seeded Bioflex plate, was subjected to injuries with 30 psi valve pressure, 3.5~4.5 gas pulse pressure for 50 ms controller. The morphological changes HT-22 cells assessed real-time digital holographic microscopy (DHM), expressions RIP3, MLKL, Akt, p-Akt, mTOR, p-mTOR detected...
Objective To estimate whether the ligation of bilateral internal carotid artery in combination with one vertebral can lead to chronic cerebral hypoperfusion. Methods The sham operation, 2-VO and 3-VO rat models were subjected matching operation. Four weeks after cortical blood flow was determined. The learning memory abilities measured Morris water maze test eight later, then rats sacrificed observe morphological change hippocampal CA1 region. Results Compared operation...
Objective To explore electrophysiologic mechanisms underlying posttraumatic epilepsy on the cellular and synaptic level.Methods Whole cell voltage - clamp recordings were used to examine intrinsic excitability evoked events from CA1 pyramidal cells in slices prepared fluid percussion injury (FPI) rat at various times after brain injury.Results We find that FPI rats show:( 1 ) increased membrane input resistance time constant,and decreased threshold current of action potential,( 2 paired...
Objective To investigate the effect of mild hypothermia on gene transcription and protein expression amyloid - β peptide (Aβ) following by traumatic brain injury in rats.Methods Sixty adult male Sprague- Dawley rats were randomly divided into three groups ( n =20/group):TBI with group (32℃),TBI normothermia (37℃),and sham- operated group.The TBI model was induced a fluid percussion device. Hypothermia intervention for 6 h immediately initiated group.At 24 after TBI,rats sacrificed...
Objective To explore the effect and mechanism of necroptosis related proteins in middle cerebral artery occlusion (MCAO) induced brain ischemia/reperfusion injury mice. Methods C57BL/6 mice were used to establish model by MCAO. MCAO treated with z-VAD.fmk (zVAD, 1.1 g/kg), GSK’872 (0.7 g/kg) combined intervention zVAD GSK’872, neurological defect was evaluated mNSS while infarct volume measured TTC staining. Western blot immunofluorescence assay detect protein expression location...
Objective To investigate the neuroprotective effect of Ghrelin on traumatic brain injury (TBI) in mice. Methods TBI model C57BL / 6 mice was established by electronic cortical impact instrument (eCCI). According to random figure table method, twenty-four were randomly divided into sham group(Sham group), TBI group and intervention group(Ghrelin group) with 8 each group. The group.The injected intraperitoneally 0.5 g/kg before 1 h after respectively. And Sham same amount normal saline....