A5070608680- Nerve injury and regeneration
- Bone Tissue Engineering Materials
- Spinal Cord Injury Research
- Electrospun Nanofibers in Biomedical Applications
- Tissue Engineering and Regenerative Medicine
- Osteoarthritis Treatment and Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Bone Metabolism and Diseases
- RNA Interference and Gene Delivery
- Periodontal Regeneration and Treatments
- Uterine Myomas and Treatments
- Orthopaedic implants and arthroplasty
- Nerve Injury and Rehabilitation
- Mesenchymal stem cell research
- Cancer Mechanisms and Therapy
- Graphene and Nanomaterials Applications
- Advanced Sensor and Energy Harvesting Materials
- Endodontics and Root Canal Treatments
- Advanced Battery Materials and Technologies
- Magnesium Alloys: Properties and Applications
- Advanced Battery Technologies Research
- Bone health and treatments
- Advancements in Battery Materials
- Extracellular vesicles in disease
- 14-3-3 protein interactions
Hôpital du Sacré-Cœur de Montréal
2025
Université de Montréal
2025
Baoding People's Hospital
2024
Xi'an Honghui Hospital
2020-2024
Xi'an Jiaotong University
2020-2024
Weinan Normal University
2024
Kunming Medical University
2022
Second Affiliated Hospital of Kunming Medical College
2022
Chinese People's Armed Police Force
2010-2019
Chinese People's Armed Police General Hospital
2010-2019
Neural stem cells (NSCs) are considered to be prospective replacements for neuronal cell loss as a result of spinal cord injury (SCI). However, the survival and differentiation NSCs strongly affected by unfavorable microenvironment induced SCI, which critically impairs their therapeutic ability treat SCI. Herein, strategy fabricate PDGF-MP hydrogel (PDGF-MPH) microspheres (PDGF-MPHM) instead bulk hydrogels is proposed dramatically enhance efficiency platelet-derived growth factor mimetic...
Abstract Topographical guidance and chemotaxis are crucial factors for peripheral nerve regeneration. This study describes the preparation of highly aligned poly(ε‐caprolactone) (PCL) fiber conduits coated with a concentration gradient growth factor (NGF) (A/G‐PCL) using newly designed electrospinning receiving device. The A/G‐PCL confirmed in vitro to enhance attract neurite longitudinal dorsal root ganglion (DRG) neurons toward their high‐concentration side. In vivo, observed direct...
Traumatic spinal cord injury (SCI) causes neuronal death, demyelination, axonal degeneration, inflammation, glial scar formation, and cystic cavitation resulting in interruption of neural signaling loss nerve function. Multifactorial targeted therapy is a promising strategy for SCI.The anti-inflammatory peptide KAFAKLAARLYRKALARQLGVAA (KAFAK) brain-derived neurotrophic factor (BDNF)-modified hyaluronan-methylcellulose (HAMC) hydrogel was designed minimally invasive, localized, sustained...
The nerve conduit with biofunctionalities can regulate neurite outgrowth, as well the migration, proliferation, and myelination activity of Schwann cells. In present study, polycaprolactone (PCL) conduits are coated Naphthalene-phenylalanine-phenylalanine-glycine-arginine-glycine-aspartic (Nap-FFGRGD) Naphthalene-phenylalanine-phenylalanine-glycine-cysteine-aspartic-proline-glycine-tyrosine-isoleucine-glycine-serine-arginine (Nap-FFGCDPGYIGSR) by self-assembly. vitro studies demonstrate that...
Peripheral nerves are unique in their remarkable elasticity. Schwann cells (SCs), important components of the peripheral nervous system (PNS), constantly subjected to physiological and mechanical stresses from dynamic stretching compression forces during movement. So far, it is not clear if SCs sense respond signals. It also unknown whether stimuli can interfere with intercellular communications between neurons SCs, what role extracellular vesicles (EVs) play this process. The present study...
The intricate electrophysiological functions and anatomical structures of spinal cord tissue render the establishment in vitro models for cord-related diseases highly challenging. Currently, both vivo are still underdeveloped, complicating exploration development effective therapeutic drugs or strategies. Organoids cultured from human induced pluripotent stem cells (hiPSCs) hold promise as suitable diseases. However, cultivation organoids predominantly relies on Matrigel, a matrix derived...
Abstract Active artificial bone substitutes are crucial in repair and reconstruction. Calcium phosphate cement (CPC) is known for its biocompatibility, degradability, ability to fill various shaped defects. However, low osteoinductive capacity limits regeneration applications. Effectively integrating magnesium ions with CPC remains a challenge. Herein, we developed malate-modified (MCPC). Incorporating 5% malate significantly enhances the compressive strength of (6.18 ± 0.49) MPa, reduces...
Spinal cord organoids are of significant value in the research spinal cord-related diseases by simulating disease states, thereby facilitating development novel therapies. However, complexity structure and physiological functions, along with lack human-derived inducing components, presents challenges vitro construction human organoids. Here, we introduce a decellularized placenta-derived extracellular matrix hydrogel (DPECMH) and, combined new induction protocol, successfully construct The...
ABSTRACT Epoxy asphalt (EA) concretes have been widely used in the pavement of orthotropic steel bridge decks. The objective this study was to figure out enhanced effects natural fibrous attapulgite (ATT) as a reinforced nanofiller ATT/EA nanocomposites through comparison properties composites with series various nanoclay loadings. rheological properties, glass transition, thermal stability, mechanical and morphology were characterized. Furthermore, low‐temperature flexibility investigated....
Calcium phosphate cement (CPC) has been widely studied, but its lack of osteoinductivity and inadequate mechanical properties limit application, while strontium is able to promote bone formation inhibit resorption. In this study, different proportions tristrontium silicate were introduced create a novel strontium-modified calcium (SMPC). The physicochemical SMPC CPC compared, the microstructures cements characterized with scanning electron microscopy assays. Then, effect on cell...
There is little research on long-term, patient-centered outcomes in critically ill patients undergoing tracheostomy for secretion management or prolonged ventilation. The goal of this study was to determine and compare hospital long-term mortality, incidence new institutionalization amongst who underwent an ICU these two aforementioned indications. This a single center historic cohort all received ventilation from 2011 2022. We compared mortality between groups. A 247 (133 management, 114...
Neural tissue engineering is an essential strategy to repair long-segment peripheral nerve defects. Modification of the conduit effective way improve local microenvironment injury site and facilitate regeneration. However, concurrent release multiple growth cues that regulate activity Schwann cells neurons remains a challenge. The present study involved fabrication composite hydrogel, specifically methacrylate-anhydride gelatin-ciliary neurotrophic factor/insulin-like factor-1...
Spinal cord injuries (SCI) often cause severe inflammatory response and neuronal loss, which consequently deteriorates motor function. Although exogenous stem cells are considered to be vital seed for cell replacement therapy after SCI, their low survival rate efficiency of differentiation in vivo transplantation limit widespread application clinical practice. To this end, study proposed a new strategy dramatically improving the insulin-like growth factor 1 (IGF1c) mimetic peptide activate...
Abstract Background Brain-derived neurotrophic factor (BDNF) and its receptor Tropomysin-related kinase B (TrkB) are commonly up-regulated in a variety of human tumors. However, the roles BDNF/TrkB hepatocellular carcinoma (HCC) have been poorly investigated. Methods We evaluated expressions BDNF TrkB 65 cases HCC by immunohistochemical staining. Moreover, cell lines HepG2 high metastatic HCCLM3, secretory supernatant was measured ELISA, effects neutralizing antibody or Trk tyrosine...
Modified macroporous structures and active osteogenic substances are necessary to overcome the limited bone regeneration capacity low degradability of self-curing calcium phosphate cement (CPC). Curcumin (CUR), which possesses strong activity poor aqueous solubility/bioavailability, esterifies side chains in hyaluronic acid (HA) form a water-soluble CUR-HA macromolecule. In this study, we incorporated glucose microparticles (GMPs) into CPC powder fabricate CUR-HA/GMP/CPC composite, not only...
Background: Spinal cord injury (SCI) induces neuronal death and disrupts the nerve fiber bundles, which leads to partial or complete sensorimotor function loss of limbs.Transplantation exogenous neurons derived from stem cells lesion site becomes a new neurorestorative strategy for SCI treatment.Spermatogonial (SSCs) can attain pluripotency features by converting embryonic stem-like in vitro.However, differentiating SSCs into lineage-specific is quite difficult low efficiency.Methods:...
Bone tissue engineering considers bone scaffolds as a key method for repairing critical-sized defects. Bone's unique combination of organic and inorganic elements, porous structure, mechanical strength is crucial. However, many artificial overlook the potential disruption to natural repair process, hindering clinical translation. We propose biomimetic perspective design that closely replicate bone's composition, strength, physiological process repair. The across four dimensions significantly...
// Shengqi Zang 1, * , Lei Zhu 2, Kefu Luo 3 Rui Mu 4 Feng Chen 1 Xiaocui Wei Xiaodong Yan Biyao Han Xiaolei Shi Qintao Wang 5 and Jin Department of Stomatology, Jinling Hospital, Medical School Nanjing University, Nanjing, Jiangsu 210002, P.R. China 2 Prosthodontics, The Fourth Military Xi'an, Shaanxi 710023, Urumqi General Hospital PLA, 830000, Southern Guangzhou, Guangdong 510515, Periodontics, These authors contributed equally to this work Correspondence to: Jin, email: ljin@nju.edu.cn...
Schwann cell (SC) transplantation is an attractive strategy for spinal cord injury (SCI). However, the efficacy of SC has been limited by poor migratory ability SCs in astrocyte-rich central nervous system (CNS) environment and inability to intermingle with host astrocyte. In this study, we first magnetofected polysialyltransferase-functionalized superparamagnetic iron oxide nanoparticles (PST/SPIONs) induce overexpression polysialylation neural adhesion molecule (PSA-NCAM) enhance migration...