Pomegranate is an important fruit crop that usually managed manually through experience. Intelligent management systems for pomegranate orchards can improve yields and address labor shortages. Fast accurate detection of pomegranates one the key technologies this system, crucial yield scientific management. Currently, most solutions use deep learning to achieve detection, but not effective in detecting small targets large parameters, computation speed slow; therefore, there room improving...

A photocatalyst-free and EDA complex-enabled radical cascade cyclization reaction of inactive alkenes with bromodifluoroacetamides was reported for the divergent synthesis fluorine-containing tetralones quinazolinones. In this transformation, persulfates as electron donors difluoro bromamide acceptors generate complex. This is a promising photochemical method advantages such mild conditions, simple operation, being metal-free, excellent functional group tolerance.

Abstract Background Aberrant regulation in the invasion of cancer cells is closely associated with their metastatic potentials. TrkB functions as a receptor tyrosine kinase and considered to facilitate tumor metastasis. Pyk2 non-receptor integrates signals cell invasion. However, little known about expression NSCLC whether involved TrkB-mediated A549 cells. Methods The was investigated by immunohistochemical staining. Both HBE were treated BDNF. TrkB, ERK phosphorylations assessed western...

The aim of this study was to explore if cell autophagy is activated by Ang II before aging using human umbilical vascular endothelial cells ( HUVEC s). ultrastructural analysis s performed observe autophagosomes. LC 3‐ / 3‐I ratio determined western blot assay. β‐gal staining used identify senescence. flow cytometry evaluate apoptosis. BH 3 domain analog ABT 737 or Beclin‐1 knockdown specific sh RNA valsartan applied investigate their effects on autophagy, senescence, and apoptosis induced ....

Plenty of long non-coding RNAs (lncRNAs) play vital roles in the progression atherosclerosis. Small nucleolar RNA host gene 6 (SNHG6) is a well known lncRNA that aberrantly high expressed atherosclerosis patients. However, its function and basic mechanism events have not been clarified.The expression patterns SNHG6, miR-135a-5p, ROCK1 ROCK2 clinical samples cells were detected by RT-qPCR assays. Cell Counting Kit-8 (CCK-8), flow cytometry assays, ELISA reactive oxygen species (ROS)...

Abstract Background Brain-derived neurotrophic factor (BDNF) and its receptor Tropomysin-related kinase B (TrkB) are commonly up-regulated in a variety of human tumors. However, the roles BDNF/TrkB hepatocellular carcinoma (HCC) have been poorly investigated. Methods We evaluated expressions BDNF TrkB 65 cases HCC by immunohistochemical staining. Moreover, cell lines HepG2 high metastatic HCCLM3, secretory supernatant was measured ELISA, effects neutralizing antibody or Trk tyrosine...

Previous studies have established the important role of MIF in development pancreatic ductal adenocarcinoma (PDAC) for both therapeutic and diagnostic perspectives, but little is known about expression function D-dopachrome tautomerase (DDT), a functional homolog MIF, PDAC. In present study, we demonstrated that DDT was over-expressed PDAC tissues pattern correlated with MIF. cancer cell lines, PANC-1, BXPC-3 ASPC-1, were expressed co-localized each other endosomal compartments plasma...

Optimizing timing is critical to the design closure of integrated circuits (ICs). However, most existing algorithms for circuit placement focus on optimization wirelength instead metrics. This article presents a timing-driven framework. It consists global stage based net weighting with momentum, and detailed Lagrangian multipliers. By improving preconditioners engines facilitate discrete local search, we have achieved superior improvement benchmarks from ICCAD 2015 contest, including worst...

SIRT1 is a pleiotropic protein that plays critical and multifunctional roles in metabolism, senescence, longevity, stress-responses, cancer, has become an important therapeutic target across range of diseases. Recent research demonstrated pre-mRNA undergoes alternative splicing to produce different isoforms, such as full-length SIRT1-∆Exon8 variants. Previous studies revealed these mRNA splice variants convey characteristics functions the protein, which may turn explain SIRT1. However,...

Guo DW, Sun WY, Zhu L, Zhang H, Hou X, Liang J, Jiang Liu C. Knockdown of BDNF suppressed invasion HepG2 and HCCLM3 cells, a mechanism associated with inactivation RhoA or Rac1 actin skeleton disorganization. APMIS 2012; 120: 469–76. Brain‐derived neurotrophic factor (BDNF) its primary receptor tropomysin‐related kinase B (TrkB) mediate critical signalings for supporting survival growth neurons. Even though we have previously confirmed that more expressions TrkB were closely correlated...

Abstract Background Suppressor of cytokine signaling 3 (SOCS3) is considered to inhibit responses and play a negative role in migration various cells. Proline-rich tyrosine kinase 2 (PYK2) non-receptor has been found crucial cell motility. However, little known about whether SOCS3 could regulate PYK2 pro-migratory function lung cancer. Methods The methylation status was investigated HBE A549 lines by methylation-specific PCR. cells were either treated with demethylation agent...

Smoking is identified as a risk factor for periodontitis. Carbon monoxide (CO)-releasing molecule-3 (CORM-3) compound that has demonstrated anti-inflammatory effects in vitro and vivo studies. The present study aimed to investigate the of CORM-3 on expression inflammatory osteoclastogenic cytokines human periodontal ligament cells (PDLCs) stimulated by nicotine lipopolysaccharide (LPS). were pretreated with then cultured medium presence LPS. mRNA protein levels prostaglandin E2 (PGE2),...

With the popularity of minimally invasive techniques, preoperatively determining whether mediastinal lymph node dissection (MLD) is necessary for patients with cN1/2 nonsmall cell lung cancer (NSCLC) has sparked controversy once again. This study aims to analyze different primary sites are associated distribution metastases and investigate necessity factors influencing prognosis.One hundred thirteen pathologically confirmed NSCLC N2 were included in grouped according lobes, which lesions...

In this paper, we present a new analytical 3D placement framework with bistratal wirelength model for F2Fbonded ICs heterogeneous technology nodes based on the electrostatic-based density model. The proposed framework, enabled GPU-acceleration, is capable of efficiently determining node partitioning and locations simultaneously, leveraging dedicated experimental results ICCAD 2022 contest benchmarks demonstrate that our can achieve up to 6.1% improvement 4.1% average compared first-place...

Background: miR-664b-5p accelerates the development of certain cancers, but role in hepatocellular carcinoma (HCC) has been less reported. Therefore, authors aimed to study HCC progression. Materials and Methods: expression liver cancer adjacent tissues, HepG2 SUN-475 cells, was measured by quantitative real-time polymerase chain reaction (qRT-PCR). Relationship between AKT2 predicted TargetScan confirmed dual-luciferase reporter assay, gene or protein expressions were determined performing...

Acute respiratory failure and sudden cardiac arrest caused by acute intrathoracic infection is a fatal clinical condition with low resuscitation success rate. The present study describes the case of patient empyema secondary to an lung abscess rupture, complicated severe hypoxemia. recovered well through administration multiple therapeutic measures, including medication closed chest drainage, cardiopulmonary resuscitation, extracorporeal membrane oxygenation combined continuous renal...