A5100781689- Animal Virus Infections Studies
- Enzyme-mediated dye degradation
- Spinal Fractures and Fixation Techniques
- Microbial Metabolism and Applications
- Nanoparticle-Based Drug Delivery
- Molecular Biology Techniques and Applications
- Electrochemical sensors and biosensors
- Advanced Biosensing Techniques and Applications
- Cervical and Thoracic Myelopathy
- Viral gastroenteritis research and epidemiology
- Food Quality and Safety Studies
- RNA Research and Splicing
- Gene expression and cancer classification
- Animal Disease Management and Epidemiology
- Connective tissue disorders research
- Research in Cotton Cultivation
- Fungal Biology and Applications
- Nanoplatforms for cancer theranostics
- Mycorrhizal Fungi and Plant Interactions
- Plant Pathogens and Fungal Diseases
- Spinal Hematomas and Complications
- Monoclonal and Polyclonal Antibodies Research
- Polymer Surface Interaction Studies
- Traditional Chinese Medicine Analysis
- CAR-T cell therapy research
Nanchang University
2025
Huazhong University of Science and Technology
2020-2024
Hubei Cancer Hospital
2024
Inner Mongolia Electric Power Survey & Design Institute (China)
2024
Inner Mongolia University of Technology
2020-2024
Nanjing University
2022-2023
Nanjing General Hospital of Nanjing Military Command
2022-2023
Hainan Medical University
2022-2023
Wenzhou Medical University
2022
Heilongjiang University of Chinese Medicine
2022
Poly(acrylic acid) grafted mesoporous silica nanoparticles (PAA-MSNs) were prepared by a facile graft-onto strategy, i.e., the amidation between PAA homopolymer and amino group functionalized MSNs. The resultant PAA-MSNs uniform spherical with mean diameter of approximately 150 nm, graft amount evaluated thermogravimetric analysis (TGA) was about 12 wt %. Due to covalent hydrophilic pH-responsive PAA, could be well dispersed in aqueous solution, which is favorable utilized as drug carriers...
Abstract Motivation: Proteins play a crucial role in biological activity, so much can be learned from measuring protein expression and post-translational modification quantitatively. The reverse-phase lysate arrays allow us to quantify the relative levels of many different cellular samples simultaneously. Existing approaches use parametric response curves fit dilution series data. results biased when function does not Results: We propose non-parametric approach which adapts any monotone...
Guhong injection (GH) is a compound preparation widely utilized in the treatment of cerebrovascular diseases. Accumulating evidence indicates that gut microbiota implicated development ischemic stroke (IS). However, although therapeutic potential GH IS may be mediated through microbiota, intricate relationships among gut-brain axis, biomarkers, and target proteins remain to completely explained. A rat model middle cerebral artery occlusion (MCAO) was investigate impact on IS. Our 16S rRNA...
Background Early-onset scoliosis (EOS), defined by an onset age of less than 10 years, conveys significant health risk to affected children. Identification the molecular aetiology underlying patients with EOS could provide valuable information for both clinical management and prenatal screening. Methods In this study, we consecutively recruited a cohort 447 Chinese operative EOS. We performed exome sequencing (ES) screening on these individuals their available family members (totaling 670...
Multicomponent therapeutic platforms have been proposed to minimize dosage of each drug and reduce toxicity, leading achieving a synergistic effect maximizing efficacy.
Previous studies have established the important role of MIF in development pancreatic ductal adenocarcinoma (PDAC) for both therapeutic and diagnostic perspectives, but little is known about expression function D-dopachrome tautomerase (DDT), a functional homolog MIF, PDAC. In present study, we demonstrated that DDT was over-expressed PDAC tissues pattern correlated with MIF. cancer cell lines, PANC-1, BXPC-3 ASPC-1, were expressed co-localized each other endosomal compartments plasma...
Assessing genome-wide statistical significance is an important and difficult problem in multipoint linkage analysis. Due to multiple tests on the same genome, usual pointwise level based chi-square approximation inappropriate. Permutation widely used determine significance. Theoretical approximations are available for simple experimental crosses. In this article, we propose a resampling procedure assess of QTL mapping The proposed method computationally much less intensive than permutation...
A novel controlled drug delivery system based on copolymer covalently linked paclitaxel via a disulfide bond was constructed. Copolymer with poly(ethylene glycol) (PEG) side chains and carboxyl groups the backbone prepared by radical copolymerization of tert-butyl acrylate methyl ether acrylate, followed selectively hydrolyzing to groups. Utilizing group as an active reaction site, paclitaxel, well-known chemotherapeutic drug, could be bond, loading content reach up 32 wt %. In aqueous...
Abstract Background Klippel-Feil syndrome (KFS) represents a rare anomaly characterized by congenital fusion of the cervical vertebrae. The underlying molecular etiology remains largely unknown because genetic and phenotypic heterogeneity. Methods We consecutively recruited Chinese cohort 37 patients with KFS. clinical manifestations radiological assessments were analyzed whole-exome sequencing (WES) was performed. Additionally, variants in KFS cases controls compared using burden analysis....
Production of high quality Chinese rice wine largely depends on fermentation temperature. However, there is no report the ethanol, sugars, and acids kinetics in mash treated at various temperatures. The effects temperatures were investigated. compositions concentrations glycerol, organic samples determined by HPLC method. highest ethanol concentration glycerol both attained 23°C. peak value maltose (90 g/L) was obtained 18°C. Lactic acid acetic achieved maximum values 33°C. experimental...
Lung injury is one of the leading causes death in sepsis. Abietic acid (AA) has demonstrated anti-inflammatory and bacteriostatic properties. Herein, we established a mouse model sepsis by cecal ligation puncture, intraperitoneally injected AA to treat. was assessed H&E staining inflammation bronchoalveolar lavage fluid (BALF) were counting number inflammatory cells detecting content factors. Meanwhile, also designed study effect on lipopolysaccharide (LPS)-induced response macrophage marker...
Osteoporosis is one of the most frequent diseases related with age. Previously, we have reported a novel potential drug, gossypol, for treatment osteoporosis through its regulation Wnt/ β -catenin signaling. This study aims to identify detailed mechanism gossypol in human osteoporosis. Mice injected were subjected RNA-seq analysis and transcription level WIF1 was shown be decreased dramatically gossypol-treated mice, which further confirmed by qRT-PCR western blot analysis. Luciferase...
Hyperleptinemia is a common feature of obese people, and leptin, an adipocyte-derived cytokine, believed to be important factor in the pathogenesis cervical ossification posterior longitudinal ligament(C-OPLL). So this research was identify relation between serum leptin bone metabolic markers how induced osteogenic effect C-OPLL.Sixty-four samples were selected determine concentration insulin, alkaline phosphatase. And association with these factors also examined. We evaluate on development...