A5058635098- Astro and Planetary Science
- Planetary Science and Exploration
- Solar and Space Plasma Dynamics
- Ionosphere and magnetosphere dynamics
- Geomagnetism and Paleomagnetism Studies
- Geophysics and Gravity Measurements
- Earthquake Detection and Analysis
- Pregnancy and preeclampsia studies
- T-cell and B-cell Immunology
- biodegradable polymer synthesis and properties
- Polymer Science and PVC
- Connective tissue disorders research
- Medical Imaging and Pathology Studies
- Immune Cell Function and Interaction
- Genetic factors in colorectal cancer
- Cancer Genomics and Diagnostics
- Epigenetics and DNA Methylation
- Preterm Birth and Chorioamnionitis
- Spinal Fractures and Fixation Techniques
- Urban Transport and Accessibility
- Spectroscopy Techniques in Biomedical and Chemical Research
- Heavy Metal Exposure and Toxicity
- Polymer crystallization and properties
- Atmospheric Ozone and Climate
- Transportation Planning and Optimization
Capital Medical University
2022-2025
Shandong University
2016-2024
Institute of Immunology
2024
Shanghai Jiao Tong University
2022-2024
Ruijin Hospital
2022-2024
Tongren Hospital
2022-2024
Kunming University of Science and Technology
2020-2024
First People's Hospital of Yunnan Province
2022-2024
Institute of Space Sciences
2022-2024
Hangzhou Medical College
2023
Abstract Tides are universal and affect spatially distributed systems, ranging from planetary to galactic scales. In the Earth–Moon system, effects caused by lunar tides were reported in Earth’s crust, oceans, neutral gas-dominated atmosphere (including ionosphere) near-ground geomagnetic field. However, whether a tide effect exists plasma-dominated regions has not been explored yet. Here we show evidence of tide-induced signal plasmasphere, inner region magnetosphere, which is filled with...
Abstract Plasma turbulence is a ubiquitous dynamical process that transfers energy across many spatial and temporal scales in astrophysical space plasma systems. Although the theory of anisotropic magnetohydrodynamic (MHD) has successfully described natural phenomena, its core prediction an Alfvénic transition from weak to strong MHD when cascades large small not been observationally confirmed. Here we report evidence for weak-to-strong small-amplitude, turbulent fluctuations Earth’s...
We statistically investigate convective earthward fast flows (V⊥ > 200 km/s) using data measured by the Acceleration, Reconnection, Turbulence, and Electrodynamics of Moon’s Interaction with Sun (ARTEMIS) mission in tail plasma sheet during 2011-2022. Statistical results show that under penetration induction dusk-dawn interplanetary magnetic field component (IMF By), magnetotail By aligned direction IMF on average dominates entire investigated near-lunar region,...
Abstract Background Klippel-Feil syndrome (KFS) represents a rare anomaly characterized by congenital fusion of the cervical vertebrae. The underlying molecular etiology remains largely unknown because genetic and phenotypic heterogeneity. Methods We consecutively recruited Chinese cohort 37 patients with KFS. clinical manifestations radiological assessments were analyzed whole-exome sequencing (WES) was performed. Additionally, variants in KFS cases controls compared using burden analysis....
Abstract Understanding the sources of lunar water is crucial for studying history evolution, as well interaction solar wind with Moon and other airless bodies. Recent orbital spectral observations revealed that a significant exogenous driver surficial hydration. However, shielded over period 3–5 days per month passes through Earth’s magnetosphere, during which loss hydration expected. Here we report temporal spatial distribution polar OH/H 2 O abundance, using Chandrayaan-1 Mineralogy Mapper...
Pathogenic variants in MYH3 cause distal arthrogryposis type 2A and 2B3 as well contractures, pterygia spondylocarpotarsal fusion syndromes types 1A 1B. These disorders are ultra-rare their natural course phenotypic variability not described. In this study, we summarize the clinical features genetic findings of 17 patients from 10 unrelated families with vertebral malformations caused by dominant or recessive pathogenic MYH3. Twelve novel (NM_002470.4) were identified: three them de novo...
To evaluate the role of brain-derived neurotrophic factor (BDNF)-a crucial modulator neural development and plasticity-in association between prenatal maternal anxiety, depression, perceived stress child neurodevelopment in a prospective cohort study.
Abstract Magnetic reconnection, an essential mechanism in plasma physics that changes magnetic topology and energizes charged particles, plays a vital role the dynamic processes of Jovian magnetosphere. The traditional Vasyliūnas cycle only considers effect reconnection at nightside magnetodisk. Recently, has been identified dayside magnetodisk Saturn's magnetosphere can impact auroral processes. In this study, we provide first evidence also occur Jupiter. Using data from Galileo Voyager 2...
Preterm birth (PTB) is the primary cause of neonatal mortality worldwide. Infection and inflammation are considered to be causes PTB. Cervical remodeling an important step in process preterm delivery, destruction cervical epithelial barrier triggers remodeling. The aim present study was determine effect underlying mechanism microRNA (miR)‑199a‑3p/high‑mobility group box 1 protein (HMGB1) signaling results this revealed that miR‑199a‑3p significantly decreased tissue samples from patients...
Micro-simulation packages provide an efficient and systematic approach to depicting traffic dynamics. Nonetheless, many of these models used by the micro-simulation are only calibrated with respect observed indicators such as average speed, count, so forth, while omitting non-traffic indicators. This paper aims investigate performance VISSIM TransModeler when fuel consumption, emissions, safety. A model was first for based on Next Generation SIMulation (NGSIM) trajectories. Results indicated...
The suppressive function of regulatory T (Treg) cells is tightly controlled by nutrient-fueled mechanistic target rapamycin complex 1 (mTORC1) activation, yet its dynamics and negative regulation remain unclear. Here we show that Treg-specific depletion vacuolar protein sorting 33B (Vps33B) in mice results defective Treg cell acquisition effector phenotype, which turn leads to disturbed homeostasis boosted antitumor immunity. Mechanistically, Vps33B binds with lysosomal nutrient-sensing...
Abstract We present observations of three-dimensional magnetic power spectra in wavevector space to investigate the anisotropy and scalings sub-Alfvénic solar wind turbulence at magnetohydrodynamic (MHD) scale using Magnetospheric Multiscale spacecraft. The distributions are organized a new coordinate determined by wavevectors ( <?CDATA $\hat{{\boldsymbol{\kappa }}}$?> <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" overflow="scroll"> <mml:mover accent="true"> <mml:mi...
Abstract Ultralow frequency (ULF) waves play an important role in the transport of solar wind energy to magnetosphere. In this paper, we present a ULF wave event dayside magnetosphere which shows sudden decrease from 3.1 2.3 mHz around 0756 UT on 11 January 2010, when dynamic pressure drop (from ∼5 ∼2 nPa) was observed simultaneously. The exits globally. phase differences between electric and magnetic fields indicate that compressional mode is standing before after decrease. This result...
Abstract A shock or a mini-magnetosphere was once thought to be formed by the solar wind interaction with strong lunar magnetic anomalies. However, full structure of has never been verified and whether can completely remains controversy. In this work, we present unique multipoint observation such an ARTEMIS spacecraft Chang’E-4 rover. Both deceleration penetration are observed rover on surface near anomaly. Meanwhile, is downstream from It suggested that anomaly cannot stand off wind, there...
Endoplasmic reticulum stress (ERS) plays crucial roles in maintaining regulatory T cells (Treg) stability and function, yet the underlying mechanism remains largely unexplored. Here we demonstrate that ERS-related protein transmembrane p24 trafficking 4 (TMED4) Treg-specific knockout (Tmed4ΔTreg) mice contain more Treg with impaired Foxp3 stability, signature suppressive activity, which leads to cell hyperactivation, exacerbated inflammatory phenotype boosted anti-tumor immunity mice....
Abstract. Ultra-low-frequency (ULF) waves are ubiquitous in the magnetosphere. Previous studies mostly focused on ULF dayside or near-Earth region (with radial distance R<12 RE). In this study, using data of Time History Events and Macroscale Interactions during Substorms (THEMIS) mission period from 2008 to 2015, Pc5–6 tail with XGSM∗<0, 8 RE<R<32 RE (mostly stretched magnetic field lines) studied statistically. A total 1089 azimuthal oscillating events 566 were found. The...
Abstract Dendritic cells (DC) play important roles in balancing immunity and tolerance, which β-catenin signaling plays an role, yet the underlying mechanisms remain elusive. In this study, we investigated functions of tumor suppressor adenomatous polyposis coli (APC), also a key component upstream destruction complex DC. APC depletion DC does not alter T cell homeostasis under resting conditions. However, deficiency leads to attenuated antitumor mice, exhibit fewer CD8+ more Foxp3+...
Genetic risk factors play an important role in the pathogenesis of familial intracranial aneurysms (FIAs); however, molecular mechanisms remain largely unknown.To investigate potential FIA-causing genetic variants by rare variant interrogation and a family-based genomics approach large family with extensive multigenerational pedigree FIAs.Exome sequencing (ES) was performed dominant likely (IAs). Variants were analyzed in-house developed pipeline prioritized using various filtering...
Ovarian cancer is the most lethal of gynecological malignancies. Dihydroartemisinin (DHA), a derivative artemisinin (ARS), has profound effects against human tumors. The aim this study was to provide convenient, cost-efficient technique, Fourier transform infrared (FTIR) spectroscopy, monitor and evaluate responses DHA-induced growth inhibition ovarian cells.Cell viability 50% inhibitory concentration (IC50) DHA were assessed by MTT assay. FTIR spectroscopy used cells following treatment,...
Abstract The Advanced Small Analyzer for Neutrals (ASAN) on board the Chang’E-4 Yutu-2 rover first detected energetic neutral atoms (ENAs) originating from lunar surface at various local times farside. In this work, we examine ENA energy spectra, obtained in 23 days 2019 January 11 to 2020 October 12, and find a higher differential flux dawnside than duskside. Combined with Acceleration, Reconnection, Turbulence Electrodynamics of Moon’s Interaction Sun (ARTEMIS) data, analyze correlation...