A5088436734- Single-cell and spatial transcriptomics
- Gene expression and cancer classification
- Bioinformatics and Genomic Networks
- Invertebrate Immune Response Mechanisms
- RNA and protein synthesis mechanisms
- Epigenetics and DNA Methylation
- Mosquito-borne diseases and control
- Extracellular vesicles in disease
- Complement system in diseases
- Cancer Genomics and Diagnostics
- Insect symbiosis and bacterial influences
- Immune Cell Function and Interaction
Chongqing Normal University
2023-2024
Abstract Background Single-cell RNA sequencing (scRNA-seq) and spatially resolved transcriptomics (SRT) have led to groundbreaking advancements in life sciences. To develop bioinformatics tools for scRNA-seq SRT data perform unbiased benchmarks, simulation has been widely adopted by providing explicit ground truth generating customized datasets. However, the performance of methods under multiple scenarios not comprehensively assessed, making it challenging choose suitable without practical...
Endoplasmic reticulum stress (ERS) plays crucial roles in maintaining regulatory T cells (Treg) stability and function, yet the underlying mechanism remains largely unexplored. Here we demonstrate that ERS-related protein transmembrane p24 trafficking 4 (TMED4) Treg-specific knockout (Tmed4ΔTreg) mice contain more Treg with impaired Foxp3 stability, signature suppressive activity, which leads to cell hyperactivation, exacerbated inflammatory phenotype boosted anti-tumor immunity mice....
Erythritol has shown excellent insecticidal performance against a wide range of insect species, but the molecular mechanism by which it causes mortality and sterility is not fully understood. The Drosophila melanogaster were assessed after feeding with 1M erythritol for 72 h 96 h, gene expression profiles further compared through RNA sequencing. Enrichment analysis GO KEGG revealed that expressions adipokinetic hormone (Akh), amylase (Amyrel), α-glucosidase (Mal-B1/2, Mal-A1-4, Mal-A7/8),...