A5013463705- T-cell and B-cell Immunology
- Inflammasome and immune disorders
- Immune Cell Function and Interaction
- Calcium signaling and nucleotide metabolism
- Immunotherapy and Immune Responses
- FOXO transcription factor regulation
- Epigenetics and DNA Methylation
- Adenosine and Purinergic Signaling
- Plant Molecular Biology Research
- Heme Oxygenase-1 and Carbon Monoxide
- interferon and immune responses
- Macrophage Migration Inhibitory Factor
- Complement system in diseases
- Pancreatic function and diabetes
- Cancer Immunotherapy and Biomarkers
Institute of Immunology
2024
Shanghai Jiao Tong University
2021-2024
Ruijin Hospital
2022-2024
Tongren Hospital
2022-2024
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NLRP3 inflammasome plays an important role in innate immune system through recognizing pathogenic microorganisms and danger-associated molecules. Deubiquitination of has been shown to be essential for its activation, yet the functions Ubc13, K63-linked specific ubiquitin-conjugating enzyme E2, activation are not known. In this study, we found that mouse macrophages, Ubc13 knockdown or knockout dramatically impaired activation. Catalytic activity is required control pharmacological inhibitor...
The suppressive function of regulatory T (Treg) cells is tightly controlled by nutrient-fueled mechanistic target rapamycin complex 1 (mTORC1) activation, yet its dynamics and negative regulation remain unclear. Here we show that Treg-specific depletion vacuolar protein sorting 33B (Vps33B) in mice results defective Treg cell acquisition effector phenotype, which turn leads to disturbed homeostasis boosted antitumor immunity. Mechanistically, Vps33B binds with lysosomal nutrient-sensing...
Endoplasmic reticulum stress (ERS) plays crucial roles in maintaining regulatory T cells (Treg) stability and function, yet the underlying mechanism remains largely unexplored. Here we demonstrate that ERS-related protein transmembrane p24 trafficking 4 (TMED4) Treg-specific knockout (Tmed4ΔTreg) mice contain more Treg with impaired Foxp3 stability, signature suppressive activity, which leads to cell hyperactivation, exacerbated inflammatory phenotype boosted anti-tumor immunity mice....
Abstract Dendritic cells (DC) play important roles in balancing immunity and tolerance, which β-catenin signaling plays an role, yet the underlying mechanisms remain elusive. In this study, we investigated functions of tumor suppressor adenomatous polyposis coli (APC), also a key component upstream destruction complex DC. APC depletion DC does not alter T cell homeostasis under resting conditions. However, deficiency leads to attenuated antitumor mice, exhibit fewer CD8+ more Foxp3+...
Inappropriate CD4 + T helper (T H ) cell differentiation leads to progression of inflammatory and autoimmune diseases, yet the regulatory mechanisms governing stability activity transcription factors controlling remain elusive. Here, we describe how pseudokinase serine threonine kinase 40 (STK40) facilitates 1/T 17 under pathological conditions. STK40 in cells is dispensable for immune homeostasis resting mice. However, mice with cell–specific deletion exhibit attenuated symptoms...