A5109781271- Gut microbiota and health
- Liver Disease Diagnosis and Treatment
- Microbial Natural Products and Biosynthesis
- Diet and metabolism studies
- Peptidase Inhibition and Analysis
- Software System Performance and Reliability
- Fungal Biology and Applications
- Influenza Virus Research Studies
- Enzyme Catalysis and Immobilization
- Craniofacial Disorders and Treatments
- Cancer, Stress, Anesthesia, and Immune Response
- Cyclopropane Reaction Mechanisms
- Cancer Treatment and Pharmacology
- Autophagy in Disease and Therapy
- Plant biochemistry and biosynthesis
- Environmental Monitoring and Data Management
- Research Data Management Practices
- Radiopharmaceutical Chemistry and Applications
- Glutathione Transferases and Polymorphisms
- Retinopathy of Prematurity Studies
- Monoclonal and Polyclonal Antibodies Research
- Tryptophan and brain disorders
- Innovative Educational Techniques
- Genetics and Plant Breeding
- Marine Sponges and Natural Products
Chinese Academy of Sciences
2006-2025
Tianjin Institute of Industrial Biotechnology
2025
Institute of Immunology
2024
Shanghai Jiao Tong University
2010-2024
Ruijin Hospital
2024
Tongren Hospital
2024
Tea Research Institute
2024
Union Hospital
2024
Huazhong University of Science and Technology
2023-2024
State Key Laboratory of Information Engineering in Surveying Mapping and Remote Sensing
2024
The mechanisms of morphogenesis are not well understood, yet shaping structures during development is essential for establishing correct organismal form and function. Here, we examine that help to shape the developing face crucial period facial primordia fusion. This a time when faces amniote embryos exhibit greatest degree similarity, it probably results from necessity fusion occur establish primary palate. Our show hierarchical induction mechanisms, consisting iterative signaling by Sonic...
: Non-alcoholic fatty liver disease (NAFLD) is a major public health problem in many countries. In this study, the ability of Grifola frondosa heteropolysaccharide (GFP) to ameliorate NAFLD was investigated rats fed high-fat diet (HFD). The molecular mechanisms modulating expression specific gene members related lipid synthesis and conversion, cholesterol metabolism, inflammation pathways were determined. components intestinal microflora analyzed by high-throughput next-generation 16S rRNA...
Immune checkpoint blockade (ICB) therapy, particularly antibodies targeting the programmed death receptor 1 (PD-1) and its ligand (PD-L1), has revolutionized cancer treatment. However, efficacy as a standalone therapy remains limited. Although ICB in combination with chemotherapy shows promising therapeutic responses, challenge lies amplifying chemotherapy-induced antitumor immunity effectively. This relies on efficient drug delivery to tumor cells robust antigen presentation by dendritic...
Globally, type 2 diabetes (T2DM) is on the rise. Maintaining a healthy diet crucial for both treating and preventing T2DM.As common vegetable in daily diet, broccoli has antioxidant, anti-inflammatory anticarcoma physiological activities. We developed mouse model of carried out systematic investigation to clarify function reducing T2DM symptoms controlling intestinal flora. The findings demonstrated that could successfully lower fasting blood glucose (FBG), lessen insulin resistance,...
Functionalizing the symmetric carbonyl carbon of cyclohexanone to achieve stereocontrol, resulting in saturated cyclohexanes with either cis/trans or axial stereochemistry, poses significant challenges chemical synthesis, and existing methodologies are limited. In this study, we present an enzymatic reductive amination strategy attain objective. By engineering enzyme pocket sole imine reductase (IRED) M5, successfully synthesized over 80 axially chiral 4‐substituted cyclohexylamines a...
Functionalizing the symmetric carbonyl carbon of cyclohexanone to achieve stereocontrol, resulting in saturated cyclohexanes with either cis/trans or axial stereochemistry, poses significant challenges chemical synthesis, and existing methodologies are limited. In this study, we present an enzymatic reductive amination strategy attain objective. By engineering enzyme pocket sole imine reductase (IRED) M5, successfully synthesized over 80 axially chiral 4‐substituted cyclohexylamines a...
Abstract Hydrogen‐bonding catalysts have been found to catalyze one‐pot three‐component reactions of pyruvate, anilines and aldehydes afford versatile 3‐amino‐1,5‐dihydro‐2 H ‐pyrrol‐2‐ones in high yields. Both, thioureas phosphoric acids are viable for these comparable activity. The corresponding chiral also used give pyrrol‐2‐ones yields with moderate enantioselectivities.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
A pioneering pink cultivar of Auricularia cornea, first commercially cultivated in 2022, lacks genomic data, hindering research genetic breeding, gene discovery, and product development. Here, we report the de novo assembly A. cornea Fen-A1 genome provide a detailed functional annotation. The is 73.17 Mb size, contains 86 scaffolds (N50 ∼ 5.49 Mb), 59.09% GC content encodes 19,120 predicted genes with BUSCO completeness 92.60%. Comparative analysis reveals phylogenetic relatedness remarkable...
Lorentz Invariance violation is a common feature of new physics beyond the standard model. We show that symmetry Randers spaces deduces modified dispersion relation with characteristics violation. The counterparts transformation in Einstein's Special Relativity are presented explicitly. coordinate transformations unitary and form group. Generators algebra satisfied by them different from usual ones. Randersian line element as well speed light invariant under transformations. In particular,...
Chemical investigation of the marine algal-derived endophytic fungus Aspergillus alabamensis EN-547 resulted in isolation 4-epi-seco-shornephine A methyl ester (1) and carboxylic acid (2), two new secondary metabolites having a rare diketomorpholine motif, 28-acetoxy-12β,15α,25-trihydroxyergosta-4,6,8(14),22-tetraen-3-one (3), highly conjugated ergostane-type steroid, together with four known (4–7). Their chemical structures were elucidated by detailed analysis their NMR spectra, ECDs,...
Abstract Background This study aimed to evaluate the efficacy of radiomics signatures derived from polyenergetic images (PEIs) and virtual monoenergetic (VMIs) obtained through dual-layer spectral detector CT (DLCT). Moreover, it sought develop a clinical-radiomics nomogram based on DLCT for predicting cancer stage (early stage: I-II, advanced III-IV) in pancreatic ductal adenocarcinoma (PDAC). Methods A total 173 patients histopathologically diagnosed with PDAC who underwent...
Highly pathogenic avian influenza viruses of the subtype H5N1 (HPAIV-H5N1) have circulated continuously in Asia, Europe, and Africa since 2003. Investigations on environmental preference global spread processes virus are needed. We compiled 16 variables to assess their correlation with HPAIV-H5N1 occurrences by using a niche-based model called Maxent. found had strongest positive association human footprint index, as well presence certain types wetlands mild temperature (10–30 C). Outbreaks...
Oral squamous cell carcinoma (OSCC), with aggressive locoregional invasion, has a high rate of early recurrences and poor prognosis. Dihydroartemisinin (DHA), as derivative artemisinin, been found to exert potent antitumor activity. Recent studies reported that DHA suppresses OSCC growth viability through the regulation reactive oxygen species (ROS) production mitochondrial calcium uniporter. However, mechanism underlying action on OSCCs remains elusive. In study, we observed 159 genes were...
Maize is a vital staple crop that has been significantly affected by climate change, necessitating an urgent increase in its resilience against the changing climate. This review aims to address need for climatic of maize analyzing advanced methodologies and innovations employed improvement. comprehensive analysis will provide data developing more resilient varieties, ensuring food security case any challenge. Furthermore, this discusses association studies QTL identification, candidate gene...
Abstract The circadian clock mediates metabolic functions of plants and rhythmically shapes structure function microbial communities in the rhizosphere. However, it is unclear how rhythm plant hosts regulates changes rhizosphere bacterial fungal nutrient cycles. In present study, we measured diel communities, nitrogen (N) phosphorus (P) cycling 20-year-old tea plantations. were more stable their responses to than cultivars LJ43 ZC108. Nevertheless, genera with rhythms numerous had a higher...
Villins are versatile, multifunctional actin regulatory proteins. They promote stabilization and remodeling mainly via their bundling Ca
A method by combination of centrifugal ultrafiltration (CUF) sampling with liquid chromatography−mass spectrometry (LC−MS) analysis was established to evaluate the DNA structure and sequence selectivity multiple compounds in a small molecule library. The developed applied analyze extracts natural products Coptis chinensis Franch Rheum palmatum (L.). From obtained biological fingerprinting chromatograms, 7 C. 11 R. (L.) were screened out as binding agents. Most these identified standards...
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Abstract Understanding the intricate relationship between cancer clinicopathological features and anesthetics dosage is crucial for optimizing patient outcomes safety during surgery. This retrospective study investigates this in patients with non-small cell lung (NSCLC) undergoing video-assisted thoracic surgery (VATS). A comprehensive analysis of medical records was undertaken NSCLC who underwent VATS intravenous compound inhalation general anesthesia. Patients were categorized based on...