Cultivation of the endophytic fungus Chaetomium globosum, which was isolated from inner tissue marine red alga Polysiphonia urceolata, resulted in isolation chaetopyranin (1), a new benzaldehyde secondary metabolite. Ten known compounds were also isolated, including two congeners, 2-(2',3-epoxy-1',3'-heptadienyl)-6-hydroxy-5-(3-methyl-2-butenyl)benzaldehyde (2) and isotetrahydroauroglaucin (3), anthraquinone derivatives, erythroglaucin (4) parietin (5), five asperentin derivatives (6, as...

Cytoglobosins A−G (1−7), seven new cytochalasan derivatives, along with two structurally related known compounds, isochaetoglobosin D (8) and chaetoglobosin Fex (9), were isolated identified from the cultures of Chaetomium globosum QEN-14, an endophytic fungus derived marine green alga Ulva pertusa. The structures natural products as well their relative configurations elucidated on basis 1D 2D NMR spectra (COSY, HSQC, HMBC, NOESY) HRESIMS data. C (3 4) displayed cytotoxic activity against...

Four new diketopiperazines including spirobrocazines A–C (1–3) and brocazine G (4) were characterized from the mangrove-derived Penicillium brocae MA-231. Compounds 1 2 had a 6/5/6/5/6 cyclic system with rare spirocyclic center at C-2. Their structures absolute configurations determined by spectroscopic analysis, TDDFT-ECD calculations, X-ray diffraction. Compound 4 exhibited potent cytotoxicity against both sensitive cisplatin-resistant human ovarian cancer cells strong antimicrobial...

Bioassay-guided fractionation of the culture extract Aspergillus wentii EN-48, an endophytic fungus isolated from unidentified marine brown algal species genus Sargassum, led to isolation three new tetranorlabdane diterpenoids, asperolides A–C (1–3), and five related derivatives (4–8). The structures these compounds were established on basis spectroscopic interpretation, compound 1 was confirmed by X-ray crystallographic analysis. absolute configuration determined application modified...

Genome mining of the fungus Mucor irregularis (formerly known as Rhizomucor variabilis) revealed presence various gene clusters for secondary metabolite biosynthesis, including several terpene-based clusters. Investigation into chemical diversity M. QEN-189, an endophytic isolated from fresh inner tissue marine mangrove plant Rhizophora stylosa, resulted in discovery 20 structurally diverse indole-diterpenes six new compounds, namely, rhizovarins A–F (1–6). Among them, compounds 1–3...

Chevalinulins A (1) and B (2), two indole diketopiperazine alkaloids containing an unprecedented spiro[bicyclo[2.2.2]octane-diketopiperazine] skeleton, together with a known analogue neoechinulin (3), were isolated from the deep-sea cold-seep-derived fungus Aspergillus chevalieri CS-122. Their structures determined by spectroscopic analysis, single-crystal X-ray diffraction, specific rotation (SR), NMR calculations. Compounds 1 2 exhibited significant in vivo proangiogenic activity...

Ten cytochalasin derivatives, including six new methylthioether-containing chaetoglobosins (thiochaetoglobosins A-F,

Lipophilic extracts from 16 species of seaweeds collected along the Qingdao coastline were screened and evaluated for their antioxidant activities (AA) using β-carotene-linoleate assay system. The diethyl ether soluble all selected exhibited various degrees antioxidative efficacy in each screen. highest capacities among tested samples observed Rhodomela confervoides Symphyocladia latiuscula comparable with that well-known butylated hydroxytoluene greater than propyl gallate. lipophilic...

Four new highly brominated and fully substituted mono- bis-phenols, 1-(2,3,6-tribromo-4,5-dihydroxybenzyl)pyrrolidin-2-one (1), 1,2-bis(2,3,6-tribromo-4,5-dihydroxyphenyl)ethane (2), 6-(2,3,6-tribromo-4,5-dihydroxybenzyl)-2,5-dibromo-3,4-dihydroxybenzyl methyl ether (3), 2,3,6-tribromo-4,5-dihydroxybenzyl sulfone (4), were characterized from the marine red alga Symphyocladia latiuscula. In addition, five known bromophenols, bis(2,3,6-tribromo-4,5-dihydroxyphenyl)methane (5),...

Eight new α-pyrone derivatives, namely, nigerapyrones A–E (1–5) and F–H (8–10), along with two known congeners, asnipyrones B (6) A (7), were isolated from Aspergillus niger MA-132, an endophytic fungus obtained the fresh tissue of marine mangrove plant Avicennia marina. The structures these compounds elucidated on basis spectroscopic analysis. undescribed geometries trisubstituted double bonds (C-9 C-11) for asnipyrone have now been explicitly determined, while incorrect placement methyl...

Penicillium chrysogenum QEN-24S, an endophytic fungus isolated from unidentified marine red algal species of the genus Laurencia, displayed inhibitory activity against growth pathogen Alternaria brassicae in dual culture test. Chemical investigation this fungal strain resulted isolation four new (1–3 and 5) one known (4) secondary metabolites. Their structures were identified as two polyketide derivatives penicitides A B (1 2), glycerol 2-(2,4-dihydroxy-6-methylbenzoyl)-glycerol (3)...

A novel triazole carboxylic acid, penipanoid (1), two new quinazolinone alkaloids, penipanoids B (2) and C (3), a very recently reported derivative (4) were isolated from the marine sediment-derived fungus Penicillium paneum SD-44. Their structures elucidated by spectroscopic analysis, structure for 1 was confirmed X-ray crystallographic analysis. Compound represents first example of fungi, compound 2 is rare having dihydroimidazole ring system. The cytotoxicity compounds 4 antimicrobial...

A new 3H-oxepine-containing alkaloid, varioxepine (1), characterized by a structurally unprecedented condensed 3,6,8-trioxabicyclo[3.2.1]octane motif, was isolated from the marine algal-derived endophytic fungus Paecilomyces variotii. Due to low proton/carbon ratio, unambiguous assignment of planar structure and relative configuration precluded NMR experiments solved single crystal X-ray analysis. The absolute established DFT conformational analysis TDDFT-ECD calculations. Compound 1...

Six new 4-phenyl-3,4-dihydroquinolone derivatives (1-6) along with the related aflaquinolone A (7) were isolated and identified from cultures of Aspergillus nidulans MA-143, an endophytic fungus obtained fresh leaves marine mangrove plant Rhizophora stylosa. Their structures including absolute configurations determined by spectroscopic analysis electronic circular dichroism experiments, structure compound 1 was confirmed single-crystal X-ray crystallographic analysis. In bioscreening none...

Hepatocellular carcinoma (HCC) is generally acknowledged as the most common primary malignant tumor, and it known to be resistant conventional chemotherapy. Wentilactone B (WB), a tetranorditerpenoid derivative extracted from marine algae-derived endophytic fungus Aspergillus wentii EN-48, has been shown trigger apoptosis inhibit metastasis in HCC cell lines. However, mechanisms of its antitumor activity remain elucidated. We report here that WB could significantly induce cycle arrest at G2...

Sumalarins A-C (1-3), the new and rare examples of sulfur-containing curvularin derivatives, along with three known analogues (4-6), were isolated identified from cytotoxic extract Penicillium sumatrense MA-92, a fungus obtained rhizosphere mangrove Lumnitzera racemosa . Their structures established by detailed interpretation NMR MS data, compound 1 was confirmed X-ray crystallographic analysis. Compounds 1-3 5 showed potent cytotoxicity against some tested tumor cell lines. Sulfur...

Chemical investigation of the marine-sponge-derived fungus Penicillium adametzioides AS-53 resulted in identification two new bisthiodiketopiperazine derivatives, adametizines A (1) and B (2), from cultivation a liquid potato–dextrose broth (PDB) culture medium, whereas acorane sesquiterpenes, adametacorenols (3) (4), were isolated rice solid medium. The structures these compounds elucidated on basis spectroscopic analysis. absolute configuration compound 1 was determined by X-ray...

Six new disulfide-bridged diketopiperazine derivatives, brocazines A–F (1–6), along with one known analogue (7), were isolated and identified from the cytotoxic extract of Penicillium brocae MA-231, a fungus obtained fresh tissue marine mangrove plant Avicennia marina. The structures these compounds established on basis detailed interpretation NMR mass spectroscopic data. X-ray crystallographic analysis confirmed structure 1 absolute configuration 5, while configurations for 1, 4, 6 deduced...