A5086630782- Respiratory Support and Mechanisms
- Advanced Statistical Methods and Models
- Statistical Distribution Estimation and Applications
- Bayesian Methods and Mixture Models
- Airway Management and Intubation Techniques
- Statistical Methods and Bayesian Inference
- Genetic Mapping and Diversity in Plants and Animals
- Genetics and Plant Breeding
- Advanced Statistical Process Monitoring
- RNA Research and Splicing
- Statistical Methods and Inference
- Inhalation and Respiratory Drug Delivery
- Mathematical and Theoretical Epidemiology and Ecology Models
- Cardiac Arrest and Resuscitation
- Neonatal Respiratory Health Research
- COVID-19 epidemiological studies
- Genetic and phenotypic traits in livestock
- HIV/AIDS Impact and Responses
- Optimal Experimental Design Methods
- Cancer Genomics and Diagnostics
- Financial Risk and Volatility Modeling
- Carcinogens and Genotoxicity Assessment
- Intensive Care Unit Cognitive Disorders
- Evolution and Genetic Dynamics
- Congenital Diaphragmatic Hernia Studies
China Medical University
2015-2025
First Affiliated Hospital of Jinan University
2024
First Hospital of China Medical University
2012-2024
Guangxi Maternal and Child Health Hospital
2017-2022
Guangxi Center for Disease Prevention and Control
2022
Second Military Medical University
2022
Changhai Hospital
2022
Sichuan University
2022
West China Hospital of Sichuan University
2022
Shanghai East Hospital
2022
The nuclear export of the unspliced type D retrovirus mRNA depends on cis-acting constitutive transport RNA element (CTE) that has been shown to interact with human TAP (hTAP) protein promoting CTE-containing mRNAs. We report here hTAP is a 619-amino-acid extending previously identified by another 60 residues at N terminus and shares high homology predicted rat mouse proteins. found accumulates in rim nucleoplasm. further demonstrated able shuttle between nucleus cytoplasm. Identification...
Human TAP and Saccharomyces cerevisiae Mex67p belong to a family of proteins that mediate mRNA export. Computer searches identified previously two Caenorhabditis elegans genes, C15H11.3 C115H11.6, encode putative homologs hTAP (Segref et al., EMBO J, 1997, 16:3256-3271). Using RNA interference experiments in C. elegans, we found functional knockout resulted nuclear accumulation poly(A)-containing RNAs was lethal for both embryos adult nematodes. No embryonic or progeny abnormality observed...
Objective To investigate the effectiveness and safety of non-invasive high-frequency oscillatory ventilation (NHFOV) in post-extubation preterm infants. Methods This was a randomized, controlled trial. A total 149 infants aged between 25 to 34 weeks’ gestational age with birth weight <1500 g who required invasive mechanical on admission were included. After extubation, they randomized NHFOV group (n = 47), nasal intermittent positive pressure (NIPPV) 51), or continuous airway (NCPAP) 51)....
It remains unclear whether conservative oxygen therapy (COT) or liberal (LOT) is more beneficial to the clinical outcomes of intensive care unit (ICU) patients. We systematically reviewed efficacy and safety versus for ICU searched PubMed, Embase, Web Science, Scopus, Cochrane Central Register Controlled Trials, ClinicalTrials.gov, MedRxiv, BioRxiv reports on randomized controlled trials (RCTs) that compared effects COT LOT patients published in English before April 2024. The primary outcome...
Background: Early studies have found better clinical efficiency when a nebulizer was used with noninvasive positive pressure ventilation (NPPV), compared spontaneous breathing without NPPV. However, very limited research addressed factors that might affect aerosol delivery. This study aimed to investigate the influence of exhalation valves and positions on delivery during Methods: We determined in patients receiving NPPV lung model simulates breathing. Single-arch port, plateau valve,...
The fruit juice of Actinidia chinensis Planch. has antioxidant and anti-inflammation properties on patients with type 2 diabetes mellitus (T2DM), but the molecular mechanism was unclear. took serum level miR-424, Kelch-like ECH-associated protein 1 (Keap1), erythroid-derived 2-like (Nrf2), biochemical indices were measured. increased levels microRNA-424, Keap1, Nrf2 reduced interleukin-1 (IL-1) beta IL-6 in T2DM patients. SOD GSH higher while ALT AST lower consuming when compared to without...
Despite the increasing use of high-flow nasal cannula (HFNC) oxygen therapy during endoscopy examination, its impact on high-risk patients remains uncertain. we aimed to compare HFNC and conventional (COT) bronchoscopy in at for desaturation (morbid obesity, narrow trachea, or baseline hypoxemia and/or hypercapnia). In this multicenter randomized controlled trial (RCT), scheduled presenting with any factors were randomly assigned receive COT after providing written consent. Vital signs,...
TAP/NXF1 is a conserved mRNA export receptor serving as link between messenger ribonucleoproteins (mRNPs) and the nuclear pore complex. The mechanism by which TAP recognizes its substrate unclear. We show here that added to spliced mRNP in human cells. identified distinct region of targets it mRNP. Using yeast two-hybrid screens vitro binding studies, we found this coincides with direct site for U2AF35, small subunit splicing factor U2AF. This interaction evolutionarily across metazoa,...
ABSTRACT Human papillomavirus capsid proteins L1 and L2 are detected only in terminally differentiated cells, indicating that expression of the genes is blocked dividing cells. The results presented here establish human type 16 coding region contains cis -acting inhibitory sequences. When placed downstream a reporter gene, sequence reduced both mRNA protein levels an orientation-dependent manner. Deletion analysis revealed two RNA regions. We identified 5′-most 845 nucleotides acted by...
We have identified a sequence in the late 3' untranslated region of human papillomavirus type 1 mRNAs that acts posttranscriptionally to repress gene expression. Deletion analysis localized inhibitory element an AU-rich between nucleotides 6958 and 6984 on genome. This inhibits expression orientation-dependent manner. Upon transfection eucaryotic cells with plasmids containing this sequence, approximately 4-fold-lower cytoplasmic mRNA levels 64- 128-fold-lower protein were produced compared...
In this paper we propose a stochastic model for the AIDS spread in homosexual population. The probability generating function (PGF) of numbers latent persons, infective persons and cases is derived. By using PGF, it shown that expected variances covariances these satisfy some ordinary differential equations. These equations have been solved numerically to assess effects various factors on spread.
Consider linear combinations of central Wishart matrices with positive coefficients. By equating the expected values and generalized variance variances covariances, we propose approximating distributions those by distributions. Some Monte Carlo results are given to demonstrate closeness this approximation.
A pioneering pink cultivar of Auricularia cornea, first commercially cultivated in 2022, lacks genomic data, hindering research genetic breeding, gene discovery, and product development. Here, we report the de novo assembly A. cornea Fen-A1 genome provide a detailed functional annotation. The is 73.17 Mb size, contains 86 scaffolds (N50 ∼ 5.49 Mb), 59.09% GC content encodes 19,120 predicted genes with BUSCO completeness 92.60%. Comparative analysis reveals phylogenetic relatedness remarkable...
Background Inflammatory bowel disease (IBD) is a chronic, non-specific inflammatory condition characterized by periods of relapse and remission, often requiring frequent medical visits. Family members, who are central to the patient's social support network, serve as primary caregivers, facing significant physiological, psychological, financial strain. However, research on caregiver burden in IBD limited. This study aimed assess current state identify contributing factors, providing valuable...
In eukaryotes, the nuclear export of mRNA is mediated by factor 1 (NXF1) receptors. Metazoans encode additional NXF1-related proteins unknown function, which share homology and domain organization with NXF1. Some mammalian genes are expressed preferentially in brain thought to participate neuronal metabolism. To address roles factors, we studied two mouse NXF1 homologues, mNXF2 mNXF7. cells, mNXF2, but not mNXF7, exhibited activity similar that Tip-associated protein/NXF1. Surprisingly,...
Abstract This paper provides necessary and sufficient conditions for a quadratic form in singular normal random variables to be distributed as given linear combination of independent noncentral chi‐square variables. Using this result, an extension Cochran's theorem forms is derived.