A5029331616- Hemodynamic Monitoring and Therapy
- Respiratory Support and Mechanisms
- COVID-19 diagnosis using AI
- Sepsis Diagnosis and Treatment
- Mechanical Circulatory Support Devices
- Supramolecular Self-Assembly in Materials
- Muscle and Compartmental Disorders
- Machine Learning in Healthcare
- Immune Response and Inflammation
- Pneumonia and Respiratory Infections
- Lanthanide and Transition Metal Complexes
- Inflammasome and immune disorders
- COVID-19 Clinical Research Studies
- Immune cells in cancer
- Gastroesophageal reflux and treatments
- Nosocomial Infections in ICU
- Mycobacterium research and diagnosis
- Pneumocystis jirovecii pneumonia detection and treatment
- Acute Kidney Injury Research
- Cardiovascular Effects of Exercise
- Radiomics and Machine Learning in Medical Imaging
- Drug-Induced Adverse Reactions
- Thermal Regulation in Medicine
- Clinical Reasoning and Diagnostic Skills
- NF-κB Signaling Pathways
Wenzhou Medical University
2021-2025
Weatherford College
2024
Quzhou City People's Hospital
2023-2024
Second Affiliated Hospital of Zhejiang University
2024
East China University of Science and Technology
2022
Sepsis remains a significant clinical challenge owing to its complex pathophysiology and variable prognosis. The early identification of patients at higher risk poor outcomes can be crucial for improving treatment strategies. This study aimed evaluate the predictive value serum lactate albumin levels lactate/albumin (L/A) ratio 28-day prognosis in with sepsis. Patients diagnosed sepsis between January 2021 December 2022 were evaluated using retrospective cohort methodology. Inclusion...
Early targeted antibiotic therapy is crucial for improving the prognosis of immunocompromised patients with severe respiratory infections (SRIs) in intensive care unit (ICU). Metagenomic next-generation sequencing (mNGS) has shown significant value pathogen detection, but research on lower tract microorganisms remains limited. This study enrolled 234 SRIs ICU, and individuals were categorized into immunocompetent groups. We compared diagnostic performance mNGS using bronchoalveolar lavage...
An increasing number of critically ill patients are immunocompromised. These at high risk intensive care unit (ICU) admission because numerous complications. Acute respiratory failure due to severe community-acquired pneumonia (SCAP) is one the leading causes admission. Early targeted antibiotic therapy crucial for improving prognosis these patients. Metagenomic next-generation sequencing (mNGS) in bronchoalveolar lavage fluid (BALF) has shown significant value pathogen detection recent...
Fluid administration is widely used to treat hypotension in patients undergoing veno-venous extracorporeal membrane oxygenation (VV-ECMO). However, excessive fluid may lead overload can aggravate acute respiratory distress syndrome (ARDS) and increase patient mortality, predicting responsiveness of great significance for VV-ECMO patients. This prospective single-center study was conducted a medical intensive care unit (ICU) finally included 51 with ARDS the prone position (PP). Stroke volume...
Lung injury is one of the leading causes death in sepsis. Abietic acid (AA) has demonstrated anti-inflammatory and bacteriostatic properties. Herein, we established a mouse model sepsis by cecal ligation puncture, intraperitoneally injected AA to treat. was assessed H&E staining inflammation bronchoalveolar lavage fluid (BALF) were counting number inflammatory cells detecting content factors. Meanwhile, also designed study effect on lipopolysaccharide (LPS)-induced response macrophage marker...
Gadopentetate dimeglumine (Gd-DTPA) is commonly used for enhancement in magnetic resonance imaging, but rarely causes serious adverse reactions. The patient presented this report had a cardiac arrest and multiple organ dysfunction syndrome within short time after administration of Gd-DTPA. Immediately receiving an intravenous injection Gd-DTPA, the felt nausea chest tightness, developed systemic erythema. He was successfully treated using veno-arterial extracorporeal membrane oxygenation...
Developing artificial microsystems based on liquid–liquid phase separation (LLPS) to mimic cellular dynamic compartmentalization has gained increasing attention. However, limitations including complicated components and laborious fabrication techniques have hindered their development. Herein, we describe a new single-component system using peptide–oligonucleotide conjugates (POCs) produced from short elastin-like polypeptides (sELPs) oligonucleotides (ONs), which can perform thermoreversible...
Abstract Background: Either sequential organ failure assessment (SOFA) score or chest CT severity (CT-SS) is often used alone to evaluate the prognosis of patients with critical coronavirus disease 2019 (COVID-19), but each them has intrinsic deficiency. Herein, we attempted investigate predictive value combination SOFA and CT-SS for COVID-19. Materials Methods: A single-center retrospective study was performed in Second Affiliated Hospital Zhejiang University School Medicine from December...
<title>Abstract</title> Background In clinical practice, fluid administration is widely used to treat hypotension in patients undergoing veno-venous extracorporeal membrane oxygenation (VV-ECMO). However, volume expansion (VE) may aggravate acute respiratory distress syndrome (ARDS) and increase patient mortality, predicting responsiveness of great significance the treatment VV-ECMO. Methods This prospective single-center study was conducted a medical intensive care unit included 51 VV-ECMO...
Endothelial dysfunction is associated with the progression of sepsis. This study sought to probe molecular route sex-determining region on Y chromosome-box transcription factor 18 (SOX18) in sepsis-associated endothelial injury. Human umbilical vein cells (HUVECs) were treated lipopolysaccharide (LPS) establish sepsis cell model. Cell viability, lactate dehydrogenase (LDH) release, oxidative stress (reactive oxygen species/malondialdehyde/superoxide dismutase), and inflammation...
Acute kidney injury (AKI) has high morbidity and mortality in intensive care units, which can lead to chronic disease, more costs longer hospital stay. Early identification of AKI is crucial for clinical intervention. Although various risk prediction models have been developed identify AKI, the overall predictive performance varies widely across studies. Owing different disease scenarios small number externally validated cohorts models, stability applicability these critically ill patients...