A5069624301- Respiratory Support and Mechanisms
- Asthma and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- COVID-19 Clinical Research Studies
- Influenza Virus Research Studies
- Long-Term Effects of COVID-19
- Intensive Care Unit Cognitive Disorders
- SARS-CoV-2 and COVID-19 Research
- Eosinophilic Esophagitis
- Respiratory viral infections research
- Cardiac Arrest and Resuscitation
- Gout, Hyperuricemia, Uric Acid
- IL-33, ST2, and ILC Pathways
- Airway Management and Intubation Techniques
- Nosocomial Infections in ICU
- Acupuncture Treatment Research Studies
- Inhalation and Respiratory Drug Delivery
- Respiratory and Cough-Related Research
- Pediatric health and respiratory diseases
- COVID-19 and healthcare impacts
- Sepsis Diagnosis and Treatment
- Neonatal Respiratory Health Research
- Ion channel regulation and function
- Immunotherapy and Immune Responses
- Pleural and Pulmonary Diseases
University of Oxford
2018-2025
National Institute for Health Research
2021-2025
Southern Medical University
2021-2024
Oxford BioMedica (United Kingdom)
2019-2024
Wenzhou Medical University
2021-2024
Southwestern University of Finance and Economics
2024
Chengdu Medical College
2024
Woosuk University
2024
Shanghai Research Institute of Chemical Industry
2023
Chengdu University of Traditional Chinese Medicine
2020-2023
To explore the work experience of clinical first-line nurses treating patients with coronavirus disease 2019 (COVID-19).COVID-19 has been listed as an international public health emergency. Clinical are at a high risk infection, and they face lack inadequate preparation for COVID-19, leading to physical psychological disorders.A qualitative study was conducted from January February 2020 COVID-19-designated hospital in Wuhan, China. Thirty were selected using purposive sampling method. Data...
Uncontrolled hyperuricemia often leads to the development of hyperuricemic nephropathy (HN), characterized by excessive inflammation and oxidative stress. Piperine, a cinnamic acid alkaloid, possesses various pharmacological activities, such as antioxidant anti-inflammatory effects. In this study, we intended investigate protective effects piperine on adenine potassium oxonate-induced HN mice uric-acid-induced injury model in renal tubular epithelial cells (mRTECs). We observed that...
Uveitis is characterised by breakdown of the blood-retinal barrier (BRB), allowing infiltration immune cells that mediate intraocular inflammation, which can lead to irreversible damage neuroretina and loss sight. Treatment uveitis relies heavily on corticosteroids systemic immunosuppression due limited understanding disease pathogenesis. We performed single-cell RNA-sequencing retinas, as well bulk retinal pigment epithelial (RPE) from mice with experimental autoimmune (EAU) versus healthy...
Importance The impact of awake prone positioning (APP) on clinical outcomes in patients with COVID-19 and acute hypoxemic respiratory failure (AHRF) remains uncertain. Objective To assess the association APP improved among AHRF, to identify potential effect modifiers. Data Sources PubMed, Embase, Cochrane Library, ClinicalTrials.gov were searched through August 1, 2024. Study Selection Randomized trials (RCTs) examining adults AHRF that reported intubation rate or mortality included....
Prior studies have demonstrated that immunologic dysfunction underpins severe illness in COVID-19 patients, but lacked an in-depth analysis of the drivers death most critically ill patients. We performed immunophenotyping viral antigen-specific and unconventional T cell responses, neutralizing antibodies, serum proteins patients with SARS-CoV-2 infection, using influenza SARS-CoV-2-convalescent health care workers, healthy adults as controls. identify mucosal-associated invariant (MAIT)...
Abstract Mpox (monkeypox) infection cases increased recently in non-Mpox outbreak areas, potentially causing an international threat. The desire to defend against a potential has led renewed efforts develop vaccines. In this report, mice were immunized with various doses of modified vaccinia virus Ankara (MVA) evaluate the cross-reactive immune response MVA immunization protective antigens current monkeypox virus. We demonstrated that induced specific antibodies (A29, A35, B6, M1, H3, and...
Multinational studies have reported that the implementation of nonpharmaceutical interventions (NPIs) to control severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission coincided with decline other viruses, such as influenza viruses and syncytial virus.To investigate prevalence common during disease 2019 (COVID-19) pandemic.Respiratory specimens children lower tract infections (LRTIs) hospitalized at Children's Hospital Chongqing Medical University from January 1, 2018...
Eosinophils are key effector cells mediating airway inflammation and exacerbation in patients with severe eosinophilic asthma. They present increased numbers activation states the mucosa lumen. Interleukin-5 (IL-5) is eosinophil growth factor that thought to play a role priming activation. However, mechanism of these effects still not fully understood. The anti-IL-5 antibody mepolizumab reduces counts modestly but has large beneficial effect on frequency exacerbations asthma, suggesting...
Human type-2 CD8+ T cells are a cell population with potentially important roles in allergic disease. We investigated this the context of severe asthma persistent airway eosinophilia—a phenotype associated high exacerbation risk and responsiveness to cytokine-targeted therapies. In two independent cohorts we show that, contrast Th2 cells, cytokine-secreting CD8+CRTH2+ (Tc2) enriched blood airways eosinophilic asthma. Concentrations prostaglandin D2 (PGD2) cysteinyl leukotriene E4 (LTE4) also...
Rationale: The emergence of catastrophic antiphospholipid syndrome (CAPS) alongside coronavirus disease 2019 (COVID-19) is great concern, because its high mortality and unclear mechanism. This severe disease, characterized by multiple thrombi multisystem disorder, has notably diverse clinical presentations, which complicates diagnosis in practice. Now, we report a rare case CAPS patient with COVID-19. Patient concerns: A 64-year-old who mainly presented pain swelling 2 months ago progressed...