A5042640989- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory Support and Mechanisms
- Medical Imaging and Pathology Studies
- Asthma and respiratory diseases
- Cardiac, Anesthesia and Surgical Outcomes
- Abdominal Surgery and Complications
- Mobile Health and mHealth Applications
- Palliative Care and End-of-Life Issues
- Inhalation and Respiratory Drug Delivery
- Intestinal and Peritoneal Adhesions
- Interprofessional Education and Collaboration
- COVID-19 Clinical Research Studies
- Childhood Cancer Survivors' Quality of Life
- Innovations in Medical Education
- RNA Research and Splicing
- Pneumothorax, Barotrauma, Emphysema
- Obstructive Sleep Apnea Research
- COVID-19 and healthcare impacts
- Digital Mental Health Interventions
- Ultrasound in Clinical Applications
- Clinical Laboratory Practices and Quality Control
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Pulmonary Hypertension Research and Treatments
- Hospital Admissions and Outcomes
Analysis Group (United States)
2025
META Group
2025
NorthShore University HealthSystem
2013-2024
Laboratoire des Sciences de l'Ingénieur, de l'Informatique et de l'Imagerie
2021
Queen Elizabeth Hospital Birmingham
2019
Crescent University
2019
University of Edinburgh
2019
Pulmonary and Critical Care Associates
2018
University of Chicago
2002-2017
Northwestern University
2017
Honeycombing on chest computed tomography (CT) has been described in diverse forms of interstitial lung disease (ILD); however, its prevalence and association with mortality across the spectrum ILD remains unclear.
<h3>Importance</h3> Awake prone positioning may improve hypoxemia among patients with COVID-19, but whether it is associated improved clinical outcomes remains unknown. <h3>Objective</h3> To determine the recommendation of awake COVID-19–related who have not received mechanical ventilation. <h3>Design, Setting, and Participants</h3> This pragmatic nonrandomized controlled trial was conducted at 2 academic medical centers (Vanderbilt University Medical Center NorthShore HealthSystem) during...
Importance The impact of awake prone positioning (APP) on clinical outcomes in patients with COVID-19 and acute hypoxemic respiratory failure (AHRF) remains uncertain. Objective To assess the association APP improved among AHRF, to identify potential effect modifiers. Data Sources PubMed, Embase, Cochrane Library, ClinicalTrials.gov were searched through August 1, 2024. Study Selection Randomized trials (RCTs) examining adults AHRF that reported intubation rate or mortality included....
RhoA and its downstream target Rho kinase regulate serum response factor (SRF)-dependent skeletal smooth muscle gene expression. We previously reported that long-term deprivation reduces transcription of contractile apparatus encoding genes, by redistributing SRF out the nucleus. Because components stimulate activity, these observations suggest hypothesis RhoA/Rho pathway regulates SRF-dependent in part controlling subcellular localization. Our present results support this hypothesis:...
GM-CSF (granulocyte-macrophage colony-stimulating factor) has emerged as a promising target against the hyperactive host immune response associated with coronavirus disease (COVID-19).
Small bowel obstruction is a common surgical emergency, and associated with high levels of morbidity mortality across the world. The literature provides little information on conservatively managed group. aim this study was to describe burden small in UK. This prospective cohort conducted 131 acute hospitals UK between January April 2017, delivered by trainee research collaboratives. Adult patients diagnosis mechanical were included. primary outcome in-hospital mortality. Secondary outcomes...
Evaluate the safety and efficacy of Janus kinase (JAK)1/JAK2 inhibitor ruxolitinib in COVID-19-associated acute respiratory distress syndrome requiring mechanical ventilation.Phase 3 randomized, double-blind, placebo-controlled trial Ruxolitinib Participants With COVID-19-Associated Acute Respiratory Distress Syndrome Who Require Mechanical Ventilation (RUXCOVID-DEVENT; NCT04377620).Hospitals community-based private or group practices United States (29 sites) Russia (4 sites).Eligible...
We studied whether African-American race is associated with younger age and decreased survival time at diagnosis of interstitial lung disease (ILD).We performed a multicentre, propensity score-matched analysis patients an ILD followed five US hospitals between 2006 2016. African-Americans were matched other races based on time-dependent score calculated from multiple patient, physiological, diagnostic hospital characteristics. Multivariable logistic regression models used. All-cause...
Rationale: Mediastinal lymph node (MLN) enlargement on chest computed tomography (CT) is prevalent in patients with interstitial lung disease (ILD) and may reflect immunologic activation subsequent cytokine-mediated immune cell trafficking.Objectives: We aimed to determine whether MLN CT predicts clinical outcomes circulating cytokine levels ILD.Methods: measurements were obtained from scans of ILD at baseline evaluation over a 10-year period. Patients sarcoidosis drug toxicity–related...
Tobacco smoking is an established cause of pulmonary disease whose contribution to interstitial lung (ILD) incompletely characterized. We hypothesized that compared with nonsmokers, subjects who smoked tobacco would differ in their clinical phenotype and have greater mortality. performed a retrospective cohort study ILD. evaluated demographic characteristics, time clinically meaningful function decline (LFD), mortality patients stratified by status (ever vs. never) within tertiary center ILD...
Smartphones are ubiquitous, but it is unknown what physiological functions can be monitored at clinical quality. Pulmonary function a standard measure of health status for cardiopulmonary patients. We have shown phone sensors accurately walking patterns. Here we show that improved classification models predict pulmonary function, with sole inputs being motion from carried phones.Twenty-five patients performed 6-minute walk tests in rehabilitation regional hospital. They smartphones running...
Background: Although many studies have illustrated the discomfort that resident physicians feel when discussing end-of-life (EOL) issues with their patients, fewer addressed interventions to directly increase medical proficiency and comfort in conducting these discussions for translating beliefs into a formal advance care plan. Objectives: We report on an innovative curriculum conducted at The University of Chicago (NorthShore) internal medicine residency improve residents' leading...
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Abstract Background Abdominal wall hernia is a common surgical condition. Patients may present in an emergency with bowel obstruction, incarceration or strangulation. Small obstruction (SBO) serious condition associated significant morbidity. The aim of this study was to describe current management and outcomes patients obstructed the UK as identified National Audit Bowel Obstruction (NASBO). Methods NASBO collated data on adults treated for SBO at 131 hospitals between January March 2017....
Unprofessional behaviors undermine the hospital learning environment and quality of patient care.To assess impact an interactive workshop on perceptions self-reported participation in unprofessional behaviors.We conducted a pre-post survey study at 3 internal medicine residency programs. For we identified related to on-call etiquette: "blocking" admission, disparaging colleague, misrepresenting test as urgent. Formal debriefing tools were utilized guide discussion. We fielded internally...
Introduction: Agreement and correlation of arterial blood gases (ABGs) venous (VBGs) at near normal values are well described but have not been validated extremes values. We evaluated the agreement ABG VBG assessed utility as a screening tool. Methods: performed retrospective, observational study collected same time. Statistical analysis included Bland-Altman plot analysis, Pearson correlations, sensitivity/specificity tests. For limits (LOA), we set threshold ±0.10 units for pH ±2.4 mm Hg...
Rectus sheath hematoma (RSH) is an uncommon and often misdiagnosed condition. This well-described entity typically self-limited. In rare cases, the condition may be fatal. We report a case of patient with cirrhosis who died progressive RSH its subsequent complications.
Unprofessional behavior can compromise care and detract from the hospital learning environment. Discrepancy between professional behaviors formally taught what is witnessed has become increasingly evident.With funding American Board of Internal Medicine Foundation, a workshop was developed to address unprofessional related inpatient previously identified in multi-institution survey. The aims were utilize video-based education illustrate behaviors, how faculty play role promoting such...