Laura Antolini
A5064951012- Chronic Myeloid Leukemia Treatments
- Chronic Lymphocytic Leukemia Research
- Maternal and Perinatal Health Interventions
- Statistical Methods and Inference
- Statistical Methods in Clinical Trials
- Birth, Development, and Health
- Immune cells in cancer
- Obesity, Physical Activity, Diet
- Liver Disease Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Blood Pressure and Hypertension Studies
- Statistical Methods and Bayesian Inference
- Respiratory Support and Mechanisms
- Eosinophilic Disorders and Syndromes
- Hepatocellular Carcinoma Treatment and Prognosis
- Ferroptosis and cancer prognosis
- Advanced Causal Inference Techniques
- Phagocytosis and Immune Regulation
- Breast Cancer Treatment Studies
- Airway Management and Intubation Techniques
- Maternal Mental Health During Pregnancy and Postpartum
- Cardiovascular Disease and Adiposity
- Cancer Cells and Metastasis
- Maternal and fetal healthcare
- Lysosomal Storage Disorders Research
University of Milano-Bicocca
2016-2025
META Group
2025
Analysis Group (United States)
2025
Community Link
2024
University of Milan
2006-2024
ASST Fatebenefratelli Sacco
2024
Vita-Salute San Raffaele University
2024
University of Chieti-Pescara
2023
Istituti di Ricovero e Cura a Carattere Scientifico
2021
Ospedale Maggiore
2021
Imatinib slows development of chronic myeloid leukemia (CML). However, available information on morbidity and mortality is largely based sponsored trials, whereas independent long-term field studies are lacking. Consecutive CML patients who started imatinib treatment before 2005 were in complete cytogenetic remission (CCyR) after 2 years (±3 months) eligible for enrollment the multicenter Long-Term (Side) Effects (ILTE) study. Incidence first serious nonserious adverse events loss CCyR...
<h3>Importance</h3> Tracheal intubation is one of the most commonly performed and high-risk interventions in critically ill patients. Limited information available on adverse peri-intubation events. <h3>Objective</h3> To evaluate incidence nature events to assess current practice <h3>Design, Setting, Participants</h3> The International Observational Study Understand Impact Best Practices Airway Management Critically Ill Patients (INTUBE) study was an international, multicenter, prospective...
Anaplastic lymphoma kinase (ALK)-positive lymphomas respond to chemotherapy, but relapses, which bear a poor prognosis, occur. Crizotinib inhibits ALK in vitro and vivo was administered as monotherapy 11 ALK+ patients who were resistant/refractory cytotoxic therapy. The overall response rate 10 of (90.9%; 95% confidence interval [CI] = 58.7% 99.8%). Disease status at the latest follow-up is follows: four are complete (CR) (months >21, >30, >35, >40) under continuous crizotinib...
Rationale: Treatment with noninvasive ventilation (NIV) in coronavirus disease (COVID-19) is frequent. Shortage of intensive care unit (ICU) beds led clinicians to deliver NIV also outside ICUs. Data about the use COVID-19 limited.Objectives: To describe prevalence and clinical characteristics patients treated investigate factors associated failure (need for intubation or death).Methods: In this prospective, single-day observational study, we enrolled adult who were ICU from 31 hospitals...
Rationale: Cardiovascular instability/collapse is a common peri-intubation event in patients who are critically ill. Objectives: To identify potentially modifiable variables associated with cardiovascular (i.e., systolic arterial pressure <65 mm Hg [once] or <90 for >30 minutes; new/increased vasopressor requirement; fluid bolus >15 ml/kg, cardiac arrest). Methods: INTUBE (International Observational Study to Understand the Impact and Best Practices of Airway Management In Critically Ill...
To derive models suitable for outcome prediction, a crucial aspect is the availability of appropriate measures predictive accuracy, which have to be usable general class models. The Harrell's C discrimination index an extension area under ROC curve case censored survival data, owns straightforward interpretability. For model including covariates with time-dependent effects and/or covariates, original definition would require prediction individual failure times, not generally addressed in...
The goal of this work was to investigate the natural history and outcomes after treatment for spontaneous amyloid-related imaging abnormalities (ARIA)-like in cerebral amyloid angiopathy-related inflammation (CAA-ri).This a multicenter, hospital-based, longitudinal, prospective observational study inpatients meeting CAA-ri diagnostic criteria recruited through Inflammatory Cerebral Amyloid Angiopathy Alzheimer's Disease βiomarkers International Network from January 2013 March 2017. A...
ABSTRACT Background Bosutinib, a tyrosine kinase inhibitor (TKI), is effective in treating chronic myeloid leukemia (CML) patients resistant or intolerant to previous TKIs. Unlike other TKIs, bosutinib's lack of inhibition c‐KIT and PDGFR may contribute its unique tolerability profile. Similar dasatinib, it targets Bcr/Abl SRC kinases, particularly Lyn, raising safety concerns. In fact, the susceptibility Lyn −/− mice autoimmune disorders deregulation Lyn‐dependent pathways with lupus were...
Importance The impact of awake prone positioning (APP) on clinical outcomes in patients with COVID-19 and acute hypoxemic respiratory failure (AHRF) remains uncertain. Objective To assess the association APP improved among AHRF, to identify potential effect modifiers. Data Sources PubMed, Embase, Cochrane Library, ClinicalTrials.gov were searched through August 1, 2024. Study Selection Randomized trials (RCTs) examining adults AHRF that reported intubation rate or mortality included....
Objective To investigate the ability of BMI and waist circumference, single combined, in identifying children who are at risk hypertension influencing absolute blood pressure values. Methods The body weight, height, circumference 4177 5–11-year-old school [2005 (48%) girls] were collected. Elevated was defined if either systolic or diastolic values both more than 95th percentile according to sex, age height (US normative tables). Overweight obese International Obesity Task Force cut-offs....
Hyperuricemia has been shown to be a strong correlate of hypertension in children. However, the complex interaction between serum uric acid (UA), systemic blood pressure (BP), and possibly confounding factors elucidated only part.We evaluated office BP as well clinical biohumoral parameters cross-sectional cohort 501 children (280 boys 221 girls) aged 6 18 years (mean = 10.8 years) consecutively referred for cardiovascular risk assessment.Overall, 156 (31.1%) were normotensive, 122 (24.4%)...
Background. In pediatric age the prevalence of obesity is high. Obese children who do not have other risk factors than excess weight been defined as "metabolically healthy obese" (MHO). Aim. The aim this study to evaluate, in a population obese children, MHO and unhealthy (MUO) phenotype. Furthermore, we evaluated distribution Uric Acid, HOMA index Waist Height ratio (W-Hr) MUO sub-groups impact these non-traditional on probability be MUO. Methods. 1201 adolescents [54% males, (SD) 11.9...
To asses the value of computed tomography (CT)-perfusion in detection residual hepatocellular carcinoma (HCC) vascularization after transarterial chemoembolization (TACE).Thirty-two consecutive patients were prospectively included this study. All had liver cirrhosis and a confirmed HCC lesion which was treated with TACE. One month treatment, perfusion measurements lesions carried out. The CT-perfusion (CT-p) protocol performed 16 slice multidetector following parameters: 8 dynamic...
Hypertension and obesity in childhood are related to early cardiac damage, as left ventricular hypertrophy. Few studies have analyzed the independent effects of hypertension weight excess on diastolic function geometry.We studied weight, waist circumference (as an index fat distribution) blood pressure mass index, risk hypertrophy, geometry 526 children (237 girls, age range 6-15 years).Children were divided into normotensive, prehypertensive hypertensive (US Nomograms) groups,...
Abstract Background It is uncertain whether higher doses of anticoagulants than recommended for thromboprophylaxis are necessary in COVID‐19 patients hospitalized general wards Methods This a multicentre, open‐label, randomized trial performed 9 Italian centres, comparing 40 mg b.i.d. versus o.d. enoxaparin patients, between April 30 2020 and 25 2021. Primary efficacy outcome was in‐hospital incidence venous thromboembolism (VTE): asymptomatic or symptomatic proximal deep vein thrombosis...
We recently reported that activation of Trop-2 through its cleavage at R87-T88 by ADAM10 underlies Trop-2–driven progression colon cancer. However, the mechanism action and pathological impact in metastatic diffusion remain unexplored. Through searches for molecular determinants cancer metastasis, we identified TROP2 as unique up-regulation across independent metastasis models. Overexpression wild-type KM12SM human cells increased liver rates vivo immunosuppressed mice. Metastatic growth was...
Abstract Purpose: Early breast cancer presents with a remarkable heterogeneity of outcomes. Undetected, microscopic lymph node tumor deposits may account for significant fraction this prognostic diversity. Thus, we systematically evaluated the presence cell ≤0.2 mm in diameter [pN0(i+), nanometastases] and analyzed their effect. Experimental Design: Single-institution, consecutive patients 8 years median follow-up (n = 702) were studied. To maximize chances detecting micrometastases...