A5061477459- Chronic Lymphocytic Leukemia Research
- Acute Myeloid Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Hematopoietic Stem Cell Transplantation
- Lymphoma Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Acute Lymphoblastic Leukemia research
- Immunodeficiency and Autoimmune Disorders
- Microbial infections and disease research
- Infections and bacterial resistance
- Nuclear Structure and Function
- Connective tissue disorders research
- Wound Healing and Treatments
- Autoimmune and Inflammatory Disorders Research
- Childhood Cancer Survivors' Quality of Life
- T-cell and B-cell Immunology
- Respiratory viral infections research
- Testicular diseases and treatments
- Skin and Cellular Biology Research
- CNS Lymphoma Diagnosis and Treatment
- CAR-T cell therapy research
- Protein Degradation and Inhibitors
- Cancer-related gene regulation
- Pneumonia and Respiratory Infections
Jena University Hospital
2010-2020
Klinikum Magdeburg
2016-2017
Wessex Regional Genetics Laboratory
2011-2015
Salisbury District Hospital
2012-2015
Salisbury NHS Foundation Trust
2013
Johannes Gutenberg University Mainz
2003-2005
Klinik und Poliklinik für Psychosomatische Medizin und Psychotherapie
2001
Summary Whole exome sequencing was performed in a patient with myelodysplastic syndrome before and after progression to acute myeloid leukaemia. Mutations several genes, including SETBP 1 , were identified following leukaemic transformation. Screening of 328 patients disorders revealed mutations 14 (4·3%), 7 whom had −7/del(7q) 3 i(17)(q10), cytogenetic markers associated shortened overall survival increased risk evolution. frequently acquired at the time evolution, coinciding increase...
Fusion genes involving the catalytic domain of tyrosine kinases (TKs) play an important role in pathogenesis hematological malignancies and solid tumors. In BCR-ABL1-negative myeloproliferative neoplasms (MPNs) several different kinase fusion events have been described, most commonly encoding platelet-derived growth factor receptor alpha (PDGFRA) or beta (PDGFRB). Since introduction small molecule inhibitors, TK fusions emerged as prime therapeutic targets. Here, we report a recurrent...
Abstract Background Community‐acquired respiratory viruses (CARV) cause upper and lower tract infections (URTI/LRTI) may be life‐threatening for recipients of an allogeneic stem cell transplantation (allo‐SCT). Methods In a prospective study encompassing 4 winter‐seasons, we collected throat gargles (TG) at random time points from allo‐SCT (patients) controls followed them up least 3 weeks including repetitive sampling documentation symptoms. A Multiplex‐PCR system to identify 20 CARV...
Infectious complications such as invasive aspergillosis or infection with <i>Stenotrophomonas maltophilia</i> (SM) in immunocompromised patients are associated a high mortality rate. Our report concerns 40-year-old male newly diagnosed very severe aplastic anemia (vSAA) who consequence of mosquito bite was suffering from skin lesion and consecutive soft tissue phlegmon subsequent to the administration antithymocyte globulin; full-thickness autologous meshed graft successfully...
Abstract Atypical Chronic Myeloid Leukemia (aCML) is a heterogeneous disorder belonging to the group of myelodysplastic/myeloproliferative (MDS/MPN) syndromes. The molecular pathogenesis this disease still unclear and outcome poor with no improvement over last 20 years. We applied whole exome sequencing approach in 9 aCML patient samples order identify possible recurrent alterations. analysis revealed presence unique mutations 70 genes 3 cases SETBP1 Some identified as mutated initial set...