A5054609024- Pelvic and Acetabular Injuries
- Hip and Femur Fractures
- Bone fractures and treatments
- Foot and Ankle Surgery
- Orthopedic Surgery and Rehabilitation
- Orthopaedic implants and arthroplasty
- Adipose Tissue and Metabolism
- Spinal Fractures and Fixation Techniques
- Tendon Structure and Treatment
- Hip disorders and treatments
- Pregnancy-related medical research
- Metabolism, Diabetes, and Cancer
- Total Knee Arthroplasty Outcomes
- Peroxisome Proliferator-Activated Receptors
- Orthopedic Infections and Treatments
- Diabetic Foot Ulcer Assessment and Management
- Shoulder Injury and Treatment
- Lower Extremity Biomechanics and Pathologies
- Spine and Intervertebral Disc Pathology
- Muscle metabolism and nutrition
- Shoulder and Clavicle Injuries
- Elbow and Forearm Trauma Treatment
- Osteoarthritis Treatment and Mechanisms
- Neurogenetic and Muscular Disorders Research
- Knee injuries and reconstruction techniques
Jena University Hospital
2011-2022
Friedrich Schiller University Jena
2008-2018
Center for Clinical Studies
2014
University of Virginia Health System
2012
Saarland University
2011
Schiller International University
2009
BG Klinik Tübingen
2009
BG Klinikum Bergmannstrost Halle
2009
Clinical Research Center Kiel
2009
Medical University of Vienna
2004-2007
Metformin and thiazolidinediones (TZDs) are believed to exert their antidiabetic effects via different mechanisms. As evidence suggests that both impair cell respiration in vitro, this study compared on mitochondrial functions. The activity of complex I the respiratory chain, which is known be affected by metformin, was measured tissue homogenates contained disrupted mitochondria. In skeletal muscle, metformin TZDs reduced (30 mmol/l −15 ± 2%; 100 μmol/l rosiglitazone, −54 7; pioglitazone,...
Objectives: To evaluate the biomechanical performance of femoral neck system (FNS) in comparison with established methods for fixation fractures a cadaveric model. Methods: Twenty pairs fresh-frozen human femora were instrumented either dynamic hip screw and antirotation (DHS-screw), DHS-blade, 3 cannulated screws (3CS) or FNS partially paired design. The specimens randomized to 2 treatment groups based on bone mineral density (BMD), namely DHS-screw/DHS-blade FNS/3CS. A reduced unstable...
Screw fixation of pelvic ring fractures is a common, but demanding procedure and navigation techniques were introduced to increase the precision screw placement. The purpose this case series was evaluation misplacement rate functional outcome percutaneous disruptions using 2D system.Between August 2004 December 2007, 44 442 patients with injuries included for closed reduction disrupted lesions an optoelectronic 2D-fluoroscopic based system. Operating fluoroscopy time measured, as well peri-...
Fibrates are used for the treatment of dyslipidemia and known to affect mitochondrial function in vitro. To better understand mechanisms underlying their effects, fibrate actions on complex I respiratory chain cell respiration were studied In homogenates rat skeletal muscle, fenofibrate, a lesser extent clofibrate, reduced activity (10, 30, 100 μM fenofibrate: –41 ± 7%, –70 2%, –78 4%; clofibrate: –27 7%; <i>p</i> < 0.005 each). Inhibition by fenofibrate (100 μM) was confirmed state 3...
The aim of this study was to investigate the potential clinical benefit tibiotalocalcaneal arthrodesis (TTCA) with an intramedullary nail a valgus curve, two compression options, and angle-stable locking.Patients who had undergone TTCA at tertiary hospitals were eligible. Patients before beginning evaluated retrospectively, then all following patients examined prospectively. There 59 TTCAs; 55 available for analysis. Twenty-eight 27 Main Outcome Measures SF-36, Mazur-, AOFAS ankle-hindfoot...
Background: Lapidus arthrodesis with a plate and compression screw is an established procedure in hallux valgus surgery. The present study was performed to investigate the potential benefit of combined plantarly applied angle-stable, anatomically precontoured or dorsomedially angle-stable plate. Methods: In six pairs human cadaver specimens, one specimen each randomized receive dorsomedial H-shaped plate, while other received plantar Bone mineral density measured peripheral quantitative...
Thiazolidinediones (TZDs) are believed to induce insulin sensitization by modulating gene expression via agonistic stimulation of the nuclear peroxisome proliferator–activated receptor-γ (PPAR-γ). We have shown earlier that TZD troglitazone inhibits mitochondrial fuel oxidation in isolated rat skeletal muscle. In present study, soleus muscle strips were exposed TZDs examine whether inhibition is mediated PPAR-γ activation. Our findings consistently indicated direct, acute, and...
The use of preventive measures, including effective chemoprophylaxis, is essential for protection against malaria among travelers. However, data have shown that travelers and medical advisors are confused by the lack uniform recommendations numerous prophylactic regimens varying effectiveness used. To assess type measures malaria, we conducted a cross‐sectional study in 1997 departing from Nairobi Mombasa airports Kenya with European destinations. Seventy‐five percent studied were residents...
Culemann, Ulf MD, PhD; Marintschev, Ivan DM; Gras, Florian MD; Pohlemann, Tim PhD Author Information
The standard for operative treatment of acetabular fractures is open reduction and plate fixation. Recently, screw fixation-only methods through less invasive approaches are reported, but biomechanical data missing. Questions posed in this study (1) the static fixation strength different types equivalent to anterior column acetabulum? (2) does placement an additional infra-acetabular corridor increase independent used implant?Three groups screws (group II, titanium; group III, stainless...
Percutaneous iliosacral screw placement is the standard procedure for fixation of posterior pelvic ring lesions, although a transsacral path being used more frequently in recent years owing to increased fracture-fixation strength and better ability fix central bilateral sacral fractures. However, biomorphometric data osseous corridors are limited. Because these screws safe effective manner crucial using screws, we sought address precise anatomy detail look anatomic variation general...
Objectives: Screw navigation techniques with different image guidance [2-dimensional (2D) vs. 3-dimensional (3D) fluoroscopy] were evaluated for acetabular fracture surgery. Methods: Two-dimensional and 3D images analyzed visualization of osseous corridors: supra-acetabular, anterior column, posterior infra-acetabular. Forty guide wires per group placed in synthetic pelvis a prefabricated soft tissue envelope (10 group) using 2D or fluoroscopic procedure. Duration the single steps each...
An infraacetabular screw path facilitates the closure of a periacetabular fixation frame to increase plate strength in acetabular fractures up 50%. Knowledge variance corridor sizes and axes has substantial surgical relevance for safe placement.(1) What proportion healthy pelvis specimens have an that is 5 mm or larger diameter? (2) Does universal axis specific entry point exist? (3) Are there sex-specific differences size are these correlated with anthropometric parameters like age, body...
Background: The fragility fractures of the pelvis (FFP) classification was established to address specific fracture morphology and dynamic instability in elderly. Although this system is frequently used, data on intra-rater inter-rater reliabilities are lacking. Methods: Six experienced 6 inexperienced surgeons 1 surgeon trained by originator FFP (“gold standard”) each used 3 times grade computed tomography (CT) scans 60 patients from hospitals. We assessed using Fleiss kappa statistics...
Early development of contractures and progressive scoliosis with pelvic obliquity are the most significant orthopaedic problems for children intermediate form spinal muscular atrophy, SMA type II. This study deals restrictions passive range motion lower extremities in these patients.We followed up 143 patients, 74 female 69 male, II an average 5.3 years (± 4.0, 0.2 - 18.7). Their age at first examination was 8.4 6.6, 0.1 34.1) last 12.3 6.5, 0.7 37.1). The joint determined using a...
Assessment of bone graft material efficacy is difficult in humans, since invasive methods like staged CT scans or biopsies are ethically unjustifiable. Therefore, we developed a novel large animal model for the verification potential transformation synthetic substitutes into vital bone. The combines multiple imaging with corresponding histology standardized critical sized cancellous defect. Cylindrical voids (10 ml) were created medial femoral condyles both hind legs (first surgery at right...
Tibiocalcaneal arthrodesis may be the only means of obtaining a painless and stable limb when there is loss talus. We present early results prospective study on tibiocalcaneal using latest-generation retrograde intramedullary nail. In period 2006-2007, nine patients underwent with nailing. Five these had infection-related SF-36, AOFAS ankle-hindfoot, Mazur Ankle Arthrodesis scores were obtained pre-fusion, at 6 weeks, months 1 year post-fusion. The also followed up clinically radiologically....
Anatomical acetabular plates the anterior intrapelvic approach (AIP) were recently introduced to fix fractures through approach. Therefore, we asked following: (1) Does preshaped 3-dimensional suprapectineal plate interfere with or even impair fracture reduction quality? (2) How often does AIP need be extended by first (lateral) window of ilioinguinal approach?Observational case series.Two Level 1 trauma centers.Patients unstable in 2014.Fracture fixation anatomical-preshaped, ±...