Rikard Linder
A5045986754- Acute Myocardial Infarction Research
- Cardiac Imaging and Diagnostics
- Cardiac Valve Diseases and Treatments
- Coronary Interventions and Diagnostics
- Infective Endocarditis Diagnosis and Management
- Atrial Fibrillation Management and Outcomes
- Venous Thromboembolism Diagnosis and Management
- Blood Coagulation and Thrombosis Mechanisms
- Aortic Disease and Treatment Approaches
- Cardiac Arrest and Resuscitation
- Heparin-Induced Thrombocytopenia and Thrombosis
- Vascular Procedures and Complications
- Cardiac pacing and defibrillation studies
- Cardiac, Anesthesia and Surgical Outcomes
- Mechanical Circulatory Support Devices
- Antiplatelet Therapy and Cardiovascular Diseases
- Peripheral Artery Disease Management
- Cardiovascular Disease and Adiposity
- Cardiovascular Function and Risk Factors
- Wound Healing and Treatments
- Hernia repair and management
- Pelvic and Acetabular Injuries
- Cardiac Structural Anomalies and Repair
- Rheumatoid Arthritis Research and Therapies
- Cardiac electrophysiology and arrhythmias
Karolinska Institutet
2014-2025
Linköping University Hospital
2025
Karolinska University Hospital
2003-2024
Helsinki University Hospital
2024
Aarhus University Hospital
2024
Copenhagen University Hospital
2024
Tampere University Hospital
2024
University of Copenhagen
2024
Skåne University Hospital
2024
Tampere University
2024
Routine intracoronary thrombus aspiration before primary percutaneous coronary intervention (PCI) in patients with ST-segment elevation myocardial infarction (STEMI) has not been proved to reduce short-term mortality. We evaluated clinical outcomes at 1 year after aspiration.We randomly assigned 7244 STEMI undergo manual followed by PCI or alone, a registry-based, randomized trial. The end point of all-cause mortality 30 days reported previously. Death from any cause was prespecified...
The clinical effect of routine oxygen therapy in patients with suspected acute myocardial infarction who do not have hypoxemia at baseline is uncertain.In this registry-based randomized trial, we used nationwide Swedish registries for patient enrollment and data collection. Patients an saturation 90% or higher were randomly assigned to receive either supplemental (6 liters per minute 6 12 hours, delivered through open face mask) ambient air.A total 6629 enrolled. median duration was 11.6 the...
The comparative efficacy of various anticoagulation strategies has not been clearly established in patients with acute myocardial infarction who are undergoing percutaneous coronary intervention (PCI) according to current practice, which includes the use radial-artery access for PCI and administration potent P2Y12 inhibitors without planned glycoprotein IIb/IIIa inhibitors.In this multicenter, randomized, registry-based, open-label clinical trial, we enrolled either ST-segment elevation...
The benefit of fractional flow reserve (FFR)-guided complete revascularization in patients with ST-segment elevation myocardial infarction (STEMI) and multivessel coronary artery disease remains unclear.
BackgroundThe benefit of percutaneous coronary intervention (PCI) in patients with stable artery disease and severe aortic stenosis who are undergoing transcatheter aortic-valve implantation (TAVI) remains unclear.MethodsIn an international trial, we randomly assigned, a 1:1 ratio, symptomatic at least one coronary-artery fractional flow reserve 0.80 or less diameter 90% either to undergo PCI receive conservative treatment, all also TAVI. The primary end point was major adverse cardiac...
Abstract Aims An observational nationwide all-comers prospective register study to analyse outcomes after coronary artery bypass grafting (CABG) or percutaneous intervention (PCI) in unprotected left main (LMCA) disease. Methods and results All patients undergoing angiography Sweden are registered the Swedish Web-system for Enhancement Development of Evidence-based care Heart disease Evaluated According Recommended Therapies registry. Between 01/01/2005 12/31/2015, 11 137 with LMCA underwent...
Long-term data on safety and efficacy of instantaneous wave-free ratio (IFR) vs fractional flow reserve (FFR) in guiding percutaneous coronary intervention (PCI) is lacking. This study sought to evaluate the 5-year clinical outcomes IFR- FFR-guided PCI a real-world setting. We assessed all patients undergoing IFR or FFR assessment between January 1, 2014, February 16, 2022, using from SWEDEHEART (Swedish Web-System for Enhancement Development Evidence-Based Care Heart Disease Evaluated...
To evaluate the feasibility of fully percutaneous closure using a novel collagen-based vascular device after transfemoral aortic valve replacement (TAVR).TAVR is utilized increasingly for treatment severe symptomatic stenosis. Vascular complications related to access and dominate adverse event profile procedure despite progressively reducing arteriotomy caliber. The advent (MANTATM ) preliminary data suggest this could be used as routine device.A prospective observational study unselected...
Introduction Gestational diabetes mellitus (GDM) is increasingly becoming a serious public health challenge. Innovative, effective and scalable lifestyle interventions to support women with GDM manage their condition prevent adverse obstetric neonatal outcomes as well later morbidity are required. This study aims evaluate whether novel, multilingual mobile (mHealth) intervention (SPARK; SmartPhone App for gestational patients suppoRting Key behaviours glucose control) can improve...
Abstract —In the current study, we investigated molecular markers of coagulation activity, ie, prothrombin fragment 1+2 (F1+2), thrombin-antithrombin (TAT) complex, soluble fibrin (SF), and D-dimer, their relation to death, myocardial infarction, refractory angina during after anticoagulant treatment in unstable coronary artery disease. Patients with disease (N=320) were randomized a 72-hour infusion either inogatran, low-molecular-mass direct thrombin inhibitor, or unfractionated heparin....
To determine whether supplemental oxygen in patients with ST-elevation myocardial infarction (STEMI) impacts on procedure-related and clinical outcomes.The DETermination of the role Oxygen suspected Acute Myocardial Infarction (DETO2X-AMI) trial randomized (MI) to receive at 6 L/min for 6-12 h or ambient air. In this pre-specified analysis, we included only STEMI who underwent percutaneous coronary intervention (PCI). total, 2807 were included, 1361 assigned oxygen, 1446 The primary...
The aim of this study was to evaluate the implementation a novel extra corporeal cardiopulmonary (ECPR) program in greater Stockholm area with focus on feasibility, safety aspects and clinical outcomes. Prospective observational ECPR including patients OHCA from January 2020 December 2022, fulfilling criteria: age 18–65 years, initial shockable rhythm or pulseless electrical activity, witnessed arrest, bystander resuscitation refractory arrest after three cycles advance cardiac life support....
The aim of this study was to assess the performance a self-expanding valve in bicuspid aortic (BAV) stenosis.An international registry included total 712 patients with stenosis treated ACURATE neo (n=54; 7.5%) or tricuspid (n=658; 92.4%) anatomy. overall mean age 81±5.6 years. At baseline, no significant differences were found between two groups. BAV more frequently required both predilatation (94.4% vs. 78.1%, p=0.004) and post-dilation (57.4% 38.7%, p=0.007). Moderate perivalvular...
The value of family history coronary artery disease (CAD) in diagnosing acute syndrome (ACS) chest pain patients is uncertain, especially relation to high-sensitivity assays for cardiac troponin T (hs-cTnT), which have improved ACS diagnostics. Our objective was investigate the association between verified CAD and patients, overall different strata initial hs-cTnT.Data on visiting four emergency departments Sweden during 2013-2016 were cross-referenced with national registers kinship,...
In the DETO2X-AMI trial (Determination of Role Oxygen in Suspected Acute Myocardial Infarction), we compared supplemental oxygen with ambient air normoxemic patients presenting suspected myocardial infarction and found no significant survival benefit at 1 year. However, important secondary end points were not yet available. We now report prespecified cardiovascular death composite all-cause hospitalization for heart failure.In this pragmatic, registry-based randomized clinical trial, used a...