A5063258527- Bone Tissue Engineering Materials
- Anesthesia and Neurotoxicity Research
- Bone and Dental Protein Studies
- Spaceflight effects on biology
- Hematopoietic Stem Cell Transplantation
- Light effects on plants
- Anesthesia and Sedative Agents
- Periodontal Regeneration and Treatments
- Pharmaceutical studies and practices
- Bipolar Disorder and Treatment
- Medication Adherence and Compliance
- Pregnancy and Medication Impact
- Acute Lymphoblastic Leukemia research
- Sports injuries and prevention
- Nicotinic Acetylcholine Receptors Study
- Neuropeptides and Animal Physiology
- Acute Myeloid Leukemia Research
- Breast Implant and Reconstruction
- Chemotherapy-related skin toxicity
- Pharmacological Receptor Mechanisms and Effects
- Tendon Structure and Treatment
- Intraocular Surgery and Lenses
- Pediatric Pain Management Techniques
- Intensive Care Unit Cognitive Disorders
- Esophageal Cancer Research and Treatment
Medac (Germany)
2019-2022
University Medical Center of the Johannes Gutenberg University Mainz
1988-2019
Johannes Gutenberg University Mainz
1988-2019
Zero to Three
2018
KRH Klinikum Nordstadt
1996
Abstract The phase III study was designed to compare event‐free survival (EFS) after treosulfan‐based conditioning with a widely applied reduced‐intensity (RIC) busulfan regimen in older or comorbid patients acute myeloid leukemia (AML) myelodysplastic syndrome (MDS) undergoing allogeneic hematopoietic cell transplantation (HCT). A previously reported confirmatory interim analysis of the randomized clinical including 476 demonstrated statistically significant noninferiority for treosulfan...
Introduction. Compliance with immunosuppressive therapy plays a major role in the long-term success of organ transplantation. Thus, strategies to promote compliance posttransplant care are particular interest. At pharmacy department University Hospital Mainz, program for pharmaceutical transplant patients has been developed first time ever. The main objective presented study was examine influence this on liver patients' therapy. Methods. To measure compliance, medication event monitoring...
Orthopedic implant failure due to aseptic loosening and mechanical instability remains a major problem in total joint replacement. Improving osseointegration at the bone-implant interface may reduce micromotion loosening. Bone sialoprotein (BSP) has been shown enhance bone formation when coated onto titanium femoral implants rat calvarial defect models. However, most appropriate method of BSP coating, necessary level effect coating on cell behavior remain largely unknown. In this study, was...
Background: After a trauma, exuberant tissue healing with fibrosis of the joint capsule can lead to posttraumatic stiffness (PTJS). Losartan and atorvastatin have both shown their antifibrotic effects in different organ systems. Objective: The purpose this study was evaluation influence losartan on early development contracture. In addition angles, change myofibroblast numbers distribution bone sialoprotein (BSP) were assessed. Study design methods: randomized blinded experimental 24 rats,...
The effects of xenin 25, a peptide the neurotensin/xenopsin family, were examined on motility guinea pig jejunum and colon in vitro. In jejunum, induced biphasic response: first small relaxation then large contraction. colon, relaxation. tenia coli was contracted. Deletion or amidation C-terminal leucine inactivated xenin. A sequence 16 amino acids necessary to elicit full response whereas potencies all fragments including 6 acid (xenin 6), not significantly different from that 25....
Abstract The combination of the two techniques rapid prototyping 3D‐plotting and bioactive surface functionalization is presented, with emphasis on in vitro effect Bone Sialoprotein (BSP) primary human osteoblasts (hOBs). Our objective was to demonstrate BSP influence expression distinctive osteoblast markers hOBs. Secondary objectives included examinations scaffolds' stability BSP‐coating as well investigations cell viability proliferation. 3D‐plotted calcium phosphate cement (CPC)...
The leading cause of training interruption in sport is a muscle injury, for which the standard treatment nonsteroidal anti-inflammatory drugs (NSAIDs). To find alternative treatments, we investigated whether radial extracorporeal shockwave application (rESWT) could stimulate regeneration. A lesion with complete rupture (grade III tear) was set musculus rectus femoris 12-week-old Wistar rats, and NSAID diclofenac, rESWT, or combined therapy were applied on day 0, 3, 5 directly following...
Modified biomaterials have for years been the focus of research into establishing new bone substitutes. In our preceding in vitro study employing different cell cultures, we developed chemically and mechanically characterized hydrogels based on photocrosslinkable dextran derivatives demonstrated their cytocompatibility beneficial effects proliferation osteoblasts endothelial cells. present vivo study, investigate photocrosslinked dextran-based critical size defects mice to evaluate potential...
The bioactive coating of calcium phosphate cement (CPC) is a promising approach to enhance the bone-healing properties bone substitutes. purpose this study was evaluate whether CPCs with sialoprotein (BSP) results in increased formation. Forty-five female C57BL/6NRj mice an average age six weeks were divided into three groups. Either BSP-coated or uncoated three-dimensional plotted scaffold implanted drilled 2.7-mm diameter calvarial defect, defect left empty (control group; no CPC)....
Hepatic function was assessed pre-operatively and on the first sixth postoperative days in 40 healthy patients who underwent prolonged maxillofacial surgery with isoflurane or halothane anaesthesia. No major changes were observed hepatic enzymes bilirubin. One-stage prothrombin time Factor VII concentrations decreased day this change more pronounced group. The results support use of rather than for anaesthesia respect synthesising liver.
The use of injections to treat structural muscle injuries is controversially discussed. In our controlled in vitro study, we investigated the biological impact Actovegin and Traumeel alone combination on primary human skeletal cells. Cells were characterized by immunofluorescence staining for myogenic factor 5 (Myf5) MyoD, cultured with or without / Traumeel. effects these agents assayed cell viability gene expression specific markers Myf5, neural adhesion molecule (NCAM), CD31. Myotube...
TPS4158 Background: More than 50% of pts with esophageal cancer have locally advanced or metastatic disease at the time initial diagnosis. For this group chemotherapy is increasingly used intending local and distant tumor control, improvement quality life (QoL) longer survival. Previous data suggested that EGFR-targeting antibodies may be safely combined cisplatin 5-FU, in addition increase efficacy standard cisplatin/5-FU regimen [Lorenzen et al, Ann Oncol2009; 20(10): 1667-1673]. Methods:...
JANTZEN, J.-P. A. H.; KLEEMANN, P. P.; WITTON, K.; MERTZLUFFT, F.; KLEIN, M.; DICK, W. F. Author Information