A5002329948- Radiomics and Machine Learning in Medical Imaging
- Lymphoma Diagnosis and Treatment
- Medical Imaging Techniques and Applications
- Lung Cancer Treatments and Mutations
- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Lung Cancer Diagnosis and Treatment
- Cervical Cancer and HPV Research
- MRI in cancer diagnosis
- Sarcoma Diagnosis and Treatment
- Respiratory Support and Mechanisms
- Advanced X-ray and CT Imaging
- Medical Imaging and Pathology Studies
- Colorectal Cancer Surgical Treatments
- Cancer Genomics and Diagnostics
- Uterine Myomas and Treatments
- Colorectal Cancer Treatments and Studies
- Advanced Radiotherapy Techniques
- Viral-associated cancers and disorders
- Chronic Lymphocytic Leukemia Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Radiopharmaceutical Chemistry and Applications
- CNS Lymphoma Diagnosis and Treatment
- Thermal Regulation in Medicine
- Digital Radiography and Breast Imaging
University of Milano-Bicocca
2015-2025
Azienda Ospedaliera San Gerardo
2014-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2023-2024
University of Bologna
2020-2023
Policlinico S.Orsola-Malpighi
2020
Children's Hospital of Eastern Ontario
2019
University of Ottawa
2019
ASST Melegnano e della Martesana
2017
University of Bern
2017
Universidade Federal de Pernambuco
2016
Abstract Background We evaluated the incidence of invasive pulmonary aspergillosis among intubated patients with critical COVID-19 and different case definitions aspergillosis. Methods Prospective, multicenter study in adult microbiologically confirmed receiving mechanical ventilation. All included participants underwent a screening protocol for bronchoalveolar lavage galactomannan cultures performed on admission at 7 days clinical deterioration. Cases were classified as...
Anaplastic lymphoma kinase (ALK)-positive lymphomas respond to chemotherapy, but relapses, which bear a poor prognosis, occur. Crizotinib inhibits ALK in vitro and vivo was administered as monotherapy 11 ALK+ patients who were resistant/refractory cytotoxic therapy. The overall response rate 10 of (90.9%; 95% confidence interval [CI] = 58.7% 99.8%). Disease status at the latest follow-up is follows: four are complete (CR) (months >21, >30, >35, >40) under continuous crizotinib...
During acute lung injury (ALI), mechanical ventilation can aggravate inflammation by promoting alveolar distension and cyclic recruitment-derecruitment. As an estimate of the intensity inflammation, metabolic activity be measured positron emission tomography imaging [(18)F]fluoro-2-deoxy-D-glucose.To assess relationship between gas volume changes induced tidal pulmonary in patients with ALI.In 13 mechanically ventilated ALI relatively high positive end-expiratory pressure, we performed a...
Neutrophilic inflammation plays a key role in the pathogenesis of acute respiratory distress syndrome (ARDS) and lung injury (ALI). Positron emission tomography (PET) with [F]-fluoro-2-deoxy-D-glucose (FDG) can be used to image cellular metabolism that, during inflammatory processes, likely reflects neutrophils activity. The aim this study was assess magnitude regional distribution metabolic activity lungs patients ALI/ARDS by PET FDG.Prospective clinical investigation.Ten ALI/ARDS; four...
PURPOSE We compared 2 years of rituximab maintenance (RM) with a response-adapted postinduction approach in patients follicular lymphoma who responded to induction immunochemotherapy. METHODS randomly assigned treatment-naïve, advanced-stage, high-tumor burden receive standard RM or on the basis metabolic response and molecular assessment minimal residual disease (MRD). The experimental arm used three types therapies: for complete (CMR) MRD-negative patients, observation; CMR MRD-positive...
Total metabolic tumor volume (TMTV) is prognostic in lymphoma. However, cutoff values for risk stratification vary markedly, according to the delineation method used. We aimed create a standardized TMTV benchmark dataset allowing be tested and applied as reproducible biomarker. <b>Methods:</b> Sixty baseline <sup>18</sup>F-FDG PET/CT scans were identified with range of disease distributions (20 follicular, 20 Hodgkin, diffuse large B-cell lymphoma). was measured by 12 nuclear medicine...
To investigate the role of consolidation radiotherapy (cRT) in advanced-stage Hodgkin lymphoma (HL) presenting at baseline with a large nodal mass (LNM) complete metabolic response after doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD) chemotherapy.Advanced-stage (IIB-IVB) HL patients, enrolled HD 0607 trial (Clinicaltrial.gov identifier NCT00795613), both negative PET two (PET-2) six (PET-6) ABVD cycles, who presented an LNM, defined as largest diameter ≥ 5 cm, were prospectively...
Purpose The aim of this study was to evaluate the role PET/CT and sentinel lymph node (SLN) biopsy in staging high-risk endometrial cancer patients (G2 deep myometrial invasion, G3, serous clear cell carcinoma or carcinosarcoma) early clinical stage. Patients Methods From January 2006 December 2012, early-stage performing scan followed by surgery (systematic pelvic ± aortic lymphadenectomy) were included. 2010, SLN mapping with 99mTc-albumin nanocolloid blue dye cervical injection included...
A radiomic approach was applied in 18F-FDG PET endometrial cancer, to investigate if imaging features computed on the primary tumour could improve sensitivity nodal metastases detection. One hundred fifteen women with histologically proven cancer who underwent preoperative PET/CT were retrospectively considered. SUV, MTV, TLG, geometrical shape, histograms and texture inside contours. On a first group of 86 patients (DB1), univariate association LN by Mann-Whitney test neural network...
Carbapenem-resistant Acinetobacter baumannii infections are difficult to treat and a significant public health threat due intrinsic/acquired resistance limited treatment options.A retrospective, observational cohort study in patients receiving cefiderocol via Shionogi's early access program for spp (1 April 2020-30 2021; 27 sites; Italy, Spain, Germany, France). Primary outcome was clinical success, defined as resolution of infection at day 14 or 28 survival.Overall, 147 were included. sites...
Neuroendocrine neoplasms (NENs) represent a complex group of tumors arising from neuroendocrine cells, characterized by heterogeneous behavior and challenging diagnostics. Despite advancements in medical technology, NENs present major challenge early detection, often leading to delayed diagnosis variable outcomes. This review aims provide an in-depth analysis current diagnostic methods as well the evolving future directions strategies for NENs.
On-pump coronary artery bypass graft (CABG) surgery triggers an inflammatory response (IR) which may impair revascularization. The study aimed at (1) characterizing the temporal profile of IR by assaying appropriate markers in both systemic and blood, (2) determining whether (and doses of) cardiovascular drugs known to have antiinflammatory properties, namely statins ACE-inhibitors (ACEI), inhibit response.Patients scheduled for CABG (n=22) were randomized statin/ACEI combination treatment...