A5028955090- Hemophilia Treatment and Research
- Cervical and Thoracic Myelopathy
- Orthopaedic implants and arthroplasty
- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Platelet Disorders and Treatments
- Chronic Myeloid Leukemia Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Electrospun Nanofibers in Biomedical Applications
- Total Knee Arthroplasty Outcomes
- Cardiac Imaging and Diagnostics
- Advanced X-ray and CT Imaging
- Spinal Hematomas and Complications
- Medical Imaging and Analysis
- Hip disorders and treatments
- Venous Thromboembolism Diagnosis and Management
- Head and Neck Surgical Oncology
- Nerve injury and regeneration
- Musculoskeletal synovial abnormalities and treatments
- Advanced MRI Techniques and Applications
- Mesenchymal stem cell research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Eosinophilic Disorders and Syndromes
- Radiomics and Machine Learning in Medical Imaging
- Spondyloarthritis Studies and Treatments
Peking Union Medical College Hospital
2016-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2024
Shanghai Electric (China)
2023
King University
2021-2022
Peking University
2021-2022
Taian City Central Hospital
2014-2016
Northwick Park Hospital
2016
Fundación Juan March
2015
Jining Medical University
2014
Union Hospital
2010
Abstract Versatile strategies have been developed to construct electrospun fiber-based drug delivery systems for tissue regeneration and cancer therapy. We first introduce the construction of fiber scaffolds their various structures, as well commonly used types drugs. Then, we discuss some representative controlling by fibers, with specific emphasis on design endogenous external stimuli-responsive systems. Afterwards, summarize recent progress engineering, including soft engineering (such...
Anatomical deficits and resting-state functional connectivity (FC) alterations in prefrontal-thalamic-cerebellar circuit have been implicated the neurobiology of schizophrenia. However, effect structural schizophrenia on causal this remains unclear. This study was conducted to examine biased by first-episode, drug-naive patients. Structural magnetic resonance imaging (fMRI) data were obtained from 49 patients 50 healthy controls. Data analyzed voxel-based morphometry Granger causality...
Central nervous system (CNS) function recovery following stroke remains a major challenge because neural regeneration is difficult to achieve. In this study, rigid-flexible composite scaffolds consisting of nanofibers from electrospun and self-adapting injectable hydrogel were loaded with bone marrow mesenchymal stem cells (BMSCs), the effects these BMSCs on ischemic insult investigated. vitro analysis viability, migration, neurite growth, angiogenic capacity, paracrine indicated that in had...
Abstract Spinal cord injury (SCI) is a debilitating condition that leads to severe disabilities and imposes significant economic social burdens. Current therapeutic strategies primarily focus on symptom management, with limited success in promoting full neurological recovery. In response this challenge, the design of novel guidance conduits incorporating multiple gradient cues, inspired reported by biological processes, enhance spinal repair. These are fabricated using electrospinning masked...
To report the results of mid-term to long-term follow-up after primary total hip arthroplasty (THA) in hemophiliacs and hypothesize that THA can provide satisfactory outcomes these patients.Twenty-four performed 21 hemophilia patients between 2002 2012 were reviewed retrospectively, including 20 cases A 1 case B. The standard lateral approach was used for all implantations. Substitution therapy factor VIII activated prothrombin complex concentrates administered with B, respectively. Total...
Prevention of osteonecrosis (ON) has seldom been addressed. The purpose this study was to evaluate the effect resveratrol on preventing steroid-induced ON in rabbits.Seventy-two rabbits were divided into four groups: (1) NEC group: thirty treated with lipopolysaccharide (LPS) once, then methylprednisolone (MPS) daily for 3 days; (2) PRE (prevention) given one dose LPS, MPS days, and day 0 2 weeks; (3) RES (resveratrol) six weeks but without LPS/MPS; (4) CON (control) alcohol LPS/MPS. Levels...
Background: Hemophilic pseudotumor (HPT) is a rare disease with many challenges. Only few reports on surgical treatment for HPT have been published. Methods: The cases of 23 patients who had from July 1996 to December 2014 were retrospectively reviewed. Demographic data, blood loss and transfusion during surgery, outcomes, complications after surgery analyzed. Results: Eleven underwent resection; 4 excision, allograft transplantation, absorbable screw fixation; 3 resection metallic internal...
To establish the prevalence of clinically significant venous thromboembolic events (VTE) in hemophilia patients undergoing total hip arthroplasty (THA) and knee (TKA) without chemoprophylaxis a modified coagulation factor substitution.A cohort who underwent THA TKA from June 2002 to April 2017 were included. Based on World Federation Hemophilia (WFH) guidelines, substitution regimen was adopted. All under standardized postoperative protocol with routine mechanical prophylaxis against VTE....
To evaluate the rate of increase in thickness and cross-section area (CSA) ossification thoracic myelopathy with or without cervical lumbar spinal ligament ossification.A total 24 patients 170 segments (47 ligamentum flavum [OLF] 123 cases posterior longitudinal [OPLL]) between January 2012 March 2019 at a single institution were retrospectively reviewed. Demographic data, classification OPLL, Sato OLF, pre- postoperative neurological function complications recorded. The CSA segment maximum...
To investigate the safety, cost-effectiveness, and clinical outcomes of simultaneous bilateral total knee arthroplasty (TKA) in hemophilic arthropathy (HA), requirements for transfusions, complications, costs, hospital stays, Hospital Special Surgery (HSS) scores, range motion (ROM) revision rates were compared between unilateral TKA HA patients. A 36 patients 54 knees included. Compared to group, group did not require more transfusions (2.39 ± 3.13 vs 0.83 1.38 units RBCs, p > 0.05) or...
Hemophilic pseudotumor gradually erodes bone and induces fracture or deformity, causing joint dysfunction destructive osteoarthropathy. Reports about surgery for hemophilic complicated by osteoarthropathy are scarce. The object of this study was to evaluate the results complications surgical management patients We retrospectively reviewed records from July 1996 2013, found eight with recorded their demographic data, time surgery, amount blood loss transfusion, union, complications. Seven...
Abstract Degenerative scoliosis (DS) is an important degenerative lumbar disease causing spinal dysfunction and affecting the quality of life elderly, associated not only with severe back or leg pain but also complicated surgical outcomes. The pathogenesis DS still unknown. Therefore, it very to ascertain etiology establish related molecular markers predicting controlling scoliosis. For first time, we used two‐dimensional fluorescence DIGE compare serum proteome profiles 12 patients...
Hyperleptinemia is a common feature of obese people, and leptin, an adipocyte-derived cytokine, believed to be important factor in the pathogenesis cervical ossification posterior longitudinal ligament(C-OPLL). So this research was identify relation between serum leptin bone metabolic markers how induced osteogenic effect C-OPLL.Sixty-four samples were selected determine concentration insulin, alkaline phosphatase. And association with these factors also examined. We evaluate on development...
The optimal surgical approach for four-level cervical spondylotic myelopathy remains controversial. purpose of this study was to compare clinical and radiological outcomes complications between the anterior posterior approaches myelopathy.A total 19 patients underwent decompression fusion 25 laminoplasty instrumentation in study. Perioperative information, intraoperative blood loss, outcomes, were recorded. Japanese Orthopedic Association (JOA) score, 36-item short form survey (SF-36) score...
Abstract Background It is imperative to preoperatively distinguish dural ossification (DO) and thus anticipate the risks outcome of surgery for patients with ligamentum flavum (OLF). However, studies have disagreed as efficacy radiographic signs or factors predict DO surgical outcome. In additon, association between cerebrospinal fluid cross-section area ratio (CCAR) clinical had not been reported. The purpose this study was analyse CCAR its role in prediction neurological function recovery...
Abstract In spine imaging, efficient automatic segmentation is crucial for clinical decision‐making, yet current models increase accuracy at the expense of elevated parameter counts and computational complexity, complicating integration with contemporary medical devices. Addressing identified challenges, this research introduces LE‐NeXt, a framework utilizing multi‐dimensional spatial attention multi‐scale feature extraction, optimizing architecture via convolution MLP. It integrates...