A5034811221- CAR-T cell therapy research
- Lipid metabolism and disorders
- Virus-based gene therapy research
- Immune Cell Function and Interaction
- Cancer-related molecular mechanisms research
- HER2/EGFR in Cancer Research
- Advanced Breast Cancer Therapies
- Nanowire Synthesis and Applications
- Ion Transport and Channel Regulation
- Breast Cancer Treatment Studies
- Chronic Lymphocytic Leukemia Research
- Dialysis and Renal Disease Management
- Patient Dignity and Privacy
- Balance, Gait, and Falls Prevention
- Immune cells in cancer
- Lipoproteins and Cardiovascular Health
- Sepsis Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Cervical Cancer and HPV Research
- Cancer Genomics and Diagnostics
- Genetic factors in colorectal cancer
- Cellular transport and secretion
- Sodium Intake and Health
- Hearing, Cochlea, Tinnitus, Genetics
- Immunotherapy and Immune Responses
Peking University
2017-2025
Peking University Cancer Hospital
2025
Inner Mongolia Medical University
2015-2025
Inner Mongolia Autonomous Region Hospital of Traditional Chinese Medicine
2020-2023
Peking University People's Hospital
2017-2023
Inner Mongolia People's Hospital
2021
Mongolian National University
2016
Capital Medical University
2015
VEGF/VEGFR signal axis has been proven to be an important target for development of novel cancer therapies. One challenging aspect in small molecular VEGFR inhibitors is achieve sustained inhibition at tolerable doses previously seen only with the long-acting biologics. It would require high potency (low effective drug concentrations) and sufficient exposures tolerated so that concentration can maintained above within dosing period. Fruquintinib (HMPL-013) a molecule inhibitor strong...
Allogeneic chimeric antigen receptor T (CAR-T) therapy, also known as universal CAR-T (UCAR-T) offers broad applicability, high production efficiency, and reduced costs, enabling quicker access for patients. However, clinical application remains limited by challenges such immune rejection, issues with potency durability. We first screened a safe effective anti-CD70 scFv to construct cells. Anti-CD70 UCAR-T cells were then generated knocking out TRAC, B2M, HLA-DRA. To address the limitations...
Chimeric antigen receptor T cell (CAR-T) therapy has shown success in treating hematological malignancies, but its effectiveness against solid tumors is hindered by exhaustion. During vitro expansion, tonic signaling induced CAR expression contributes to CAR-T exhaustion, which can be mitigated inhibiting calcium signaling. Given that sodium citrate chelate ions and inhibit signaling, this study, we investigated whether could reduce exhaustion enhance function. We constructed anti-CD70 cells...
ABSTRACT Introduction Home hemodialysis is still in its early stages mainland China. This survey aimed to assess the perceptions of healthcare professionals and patients towards home identify barriers hindering uptake. Methods A cross‐sectional observational was conducted using convenience sampling. Healthcare specializing nephrology with end‐stage kidney disease (ESKD) across China were included. self‐reported questionnaire administered gather data on participants' demographics, attitudes,...
It is well known that chimeric antigen receptor T-cell immunotherapy (CAR-T-cell immunotherapy) has excellent therapeutic effect in haematological tumours, but it still faces great challenges solid including inefficient tumour infiltration and poor functional persistence. Flap structure-specific endonuclease 1 (FEN1), highly expressed a variety of cancer cells, plays an important role both DNA replication repair. Previous studies have reported FEN1 inhibition effective strategy for...
Cervical cancer is the third most common in women. Radiotherapy resistance remains a major obstacle for patients with cervical cancer. Somatic alterations human genomes are responsible radiotherapy resistance. Here, we performed single cell whole genome sequencing on 13 cells before and 12 after from Chinese woman patient carcinoma. We identified one damaging mutation NFKB1 (G430E), which showed significantly increased mutant allele frequency than that radiotherapy. Further functional assays...
<b><i>Background/Aims: </i></b>Hypertension or persistent high blood pressure (BP) is a leading cause of death worldwide. Extensive evidence indicates that the thiazide-sensitive Na<sup>+</sup>-Cl<sup>-</sup> cotrans-porter (NCC) affects BP via regulation renal sodium reabsorption. However, relationship between genetic variants NCC-encoding <i>SLC12A3</i> gene and hypertension in Mongolian population still ambiguous. In this study,...
Single-cell sequencing technology is a promising systematic and comprehensive approach to delineate clonal associations between cells. The present study collected 13 12 cervical cells from fresh tumour tissue prior following radiotherapy, respectively, 46-year-old female patient with exogenous-type carcinoma. Next, single-cell whole-genome analysis was performed on each cell. Examination revealed that normal could be clearly distinguished among the 25 Tumour radiotherapy almost represented...
Abstract Both vascular endothelial growth factor receptor (VEGFR) and fibroblast (FGFR) singling pathways can mediate tumor angiogenesis. Colony stimulating 1 (CSF1R) plays an important role on functions of macrophages. Recently the roles VEGFR, FGFR CSF1R in regulation T cells, tumor-associated macrophages (TAMs) myeloid-derived suppressor thereby increasing immune evasion, have been demonstrated[1-3]. Therefore, blockade angiogenesis evasion by simultaneously targeting kinases may...
Background: Luminal B-like human epidermal growth factor receptor 2 negative (Luminal B [HER2−]) is the most common molecular subtype of breast cancer (BC). Since relationship between (HER2−) BC and liver metastasis (LM) poorly defined, this retrospective study aimed to develop an LM risk nomogram for patients with lymph node-related (N + BC. Methods: Data were obtained initially diagnosed from Tianjin Medical University Cancer Institute Hospital. There 30,975 Chinese female stage I–III...
<title>Abstract</title> <bold>Purpose</bold>To construct nomograms combining clinicopathological characteristics, bone metastases (BM), viscera (VM) and cancer-related deaths (CRD) to predict the higher-risk patients with lymph node positive (N+) Luminal B (HER2-) breast cancer (BC).<bold>Method</bold>Kaplan-Meier survival analysis, Venn diagram, Bar charts were used describe data for subsequent metastasis CRD. Thirty-six characteristics extracted in univariate multivariate Cox regression...
Abstract Introduction: Daratumumab (Dara), an anti-CD38 monoclonal antibody, has been widely used in the treatment of multiple myeloma (MM). However, some MM patients exhibit primary or acquired resistance to Dara therapy. A CD38 targeting antibody-drug conjugate (ADC) HMA800067 is developed, which was conjugated with cytotoxic payload via a novel linker, aiming have superior anti-tumor efficacy Dara, even subjects treatment. Methods: characterized by ELISA-based binding assay, cell...
Mounting evidence has implicated the SLC12A3 gene in essential hypertension.Here, we examined potential associations of common variants with blood pressure traits Mongolians China.Genomic DNA was extracted from 508 unrelated Mongolian patients hypertension and 246 normotensive subjects for genotyping.The genotype distributions all selected polymorphisms were consistent Hardy-Weinberg equilibrium.The presence G allele rs7187932 polymorphism found to be associated an increased risk (OR: 1.30;...
The serum lipid profile, including LDL-C level, is associated with hypertension which the major cause of cerebrovascular disease (CVD) amounting 30% global death rate. Previous work also demonstrated important roles genetic variants SLC12A3 gene on human CVD, and other diseases in Mongolian population. However, relationship between polymorphisms individuals' profile still unknown.A panel 15 SNPs was genotyped within a 424 Mongolians pedigree cohort. associations four profiles were analyzed...
Background: Quarantine is an effective measure to contain the spread of infectious disease, however, it can be a great challenge for patients undergoing maintenance hemodialysis (MHD).The purpose this study was evaluate impact hospital-based group medical quarantine (H-GMQ) on blood pressure (BP) in MHD patients, and effect age change BP.Methods: our dialysis center who were under H-GMQ due exposure coronavirus disease 2019 (COVID-19) enrolled.Their demographic data, clinical...
Surgery, chemotherapy and radiotherapy are the gold standard treatments used for cancer. Side effects from medical radiation can be significant, particularly external beam therapy to breast, head neck regions causing fibrosis, secondary skin cancer, hair loss, oral mucositis neuropathic pain. There is significant psychological stress, depression, anxiety loss of self esteem female patients. Similar types space known damage health astronauts. Current scarring, tissue pain a high priority but...
In February 2020, an inpatient in Peking University People's Hospital (PKUPH), China, was confirmed positive for the novel coronavirus. this case, 143 hemodialysis patients were labeled as close contacts and required to be placed under hospital-based group medical quarantine (HB-GMQ) 2 weeks by authorities. After case reported, false or misleading information about flourished on social media platforms, which led infodemic. Under context, PKUPH adopted patient-centered humanistic care...
Abstract Introduction Patients undergoing hemodialysis (HD) are at a higher risk of falls than healthy individuals. Further knowledge regarding the could lead to better prevention strategies. We designed multicenter, prospective cohort study according strengthening reporting observational studies in epidemiology (STROBE) guidelines investigate incidence and factors patients Northern China. Methods six units were recruited from January 2019 2020. Data on demographics disease conditions...