A5038674267- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Pancreatic function and diabetes
- Mitochondrial Function and Pathology
- Metabolism and Genetic Disorders
- Diabetes Management and Research
- Neuroendocrine Tumor Research Advances
- Metabolism, Diabetes, and Cancer
- Neuroblastoma Research and Treatments
- Diet and metabolism studies
- RNA modifications and cancer
- ATP Synthase and ATPases Research
- Regulation of Appetite and Obesity
- Diabetes Treatment and Management
- Pancreatic and Hepatic Oncology Research
- RNA regulation and disease
- Genomics, phytochemicals, and oxidative stress
- Cancer, Hypoxia, and Metabolism
- Genetic and Kidney Cyst Diseases
- Endoplasmic Reticulum Stress and Disease
- Growth Hormone and Insulin-like Growth Factors
- Intestinal Malrotation and Obstruction Disorders
- Hedgehog Signaling Pathway Studies
- Digital literacy in education
- Educational Challenges and Innovations
- Estrogen and related hormone effects
Great Ormond Street Hospital
2015-2025
University College London
2013-2025
University of Okara
2024
Ayub Agriculture Research Institute
2021
University of Southampton
2021
The University of Texas at Dallas
2020-2021
American University of Ras Al Khaimah
2020
Hammersmith Hospital
2017
Imperial College London
2017
Institut thématique Génétique, génomique et bioinformatique
2015
Polymorphisms in the fat mass and obesity-associated gene (FTO) are associated with human obesity obesity-prone behaviors, including increased food intake a preference for energy-dense foods. FTO demethylates N6-methyladenosine, potential regulatory RNA modification, but mechanisms by which predisposes humans to remain unclear. In adiposity-matched, normal-weight humans, we showed that subjects homozygous "obesity-risk" rs9939609 A allele have dysregulated circulating levels of orexigenic...
Hyperinsulinemic hypoglycemia (HI) and congenital polycystic kidney disease (PKD) are rare, genetically heterogeneous disorders. The co-occurrence of these disorders (HIPKD) in 17 children from 11 unrelated families suggested an unrecognized genetic disorder. Whole-genome linkage analysis five informative identified a single significant locus on chromosome 16p13.2 (logarithm odds score 6.5). Sequencing the coding regions all linked genes failed to identify biallelic mutations. Instead, we...
The heterotrimeric GTP-binding protein eIF2 forms a ternary complex with initiator methionyl-tRNA and recruits it to the 40S ribosomal subunit for start codon selection thereby initiates synthesis. Mutations in EIF2S3, encoding eIF2γ subunit, are associated severe intellectual disability microcephaly, usually as part of MEHMO syndrome.Exome sequencing X chromosome was performed on three related males normal head circumferences mild learning difficulties, hypopituitarism (GH TSH...
Artikel ini membincangkan aplikasi Maqasid Shariah dalam menangani cabaran isu pemikiran kontemporari. merujuk kepada tujuan utama hukum syarak itu diadakan. Ia juga bertujuan untuk memastikan bahawa segala peraturan dan Islam membawa kebaikan serta manfaat manusia. merangkumi penjagaan agama, nyawa, akal, keturunan, harta. Kesemua elemen sebenarnya memainkan peranan penting mengimbangi perubahan sosial, budaya, moden. Ini kerana di era kontemporari, pelbagai bentuk aliran telah wujud...
Indian Education Commission has well narrated it that ‘Destiny of India is now being shaped in her classrooms’ thus teachers are considered as nation builders. They can positively influence society by motivating students to pursue their dreams and promoting peace harmony. Teachers the backbone a society. In this context, Prof. Humayun Kabir rightly said “Without good even best system bound fail. With defects be largely overcome”. It stated competence major on quality education. Therefore,...
The obesity epidemic is a significant global health issue. Improved understanding of the mechanisms that regulate appetite and body weight will provide rationale for design anti-obesity therapies. Thyroid hormones play key role in metabolic homeostasis through their interaction with thyroid hormone receptors (TRs), which function as ligand-inducible transcription factors. TR-beta isoform (TRβ) expressed ventromedial hypothalamus (VMH), brain area important control energy homeostasis. Here,...
Abstract Background Hepatocyte nuclear factor 4α (HNF4A) is a member of the receptor family ligand‐activated transcription factors. HNF4A mutations cause hyperinsulinaemic hypoglycaemia in early life and maturity‐onset diabetes young. Regular screening mutation carriers using oral glucose tolerance test has been recommended to diagnose mellitus at an stage. Glucagon‐like peptide‐1 glucose‐dependent insulinotropic polypeptide are incretin hormones, responsible for up 70% secreted insulin...
Congenital hyperinsulinism (CHI) is a common cause of hypoglycaemia due to unregulated insulin secretion from pancreatic β cells. Medical management includes use oral diazoxide (a K<sub>ATP</sub> channel agonist) and daily injectable octreotide (somatostatin analogue) therapy. However, associated with severe sideeffects such as coarse facies, hypertrichosis psychosocial/compliance issues in adolescents. Lanreotide long-acting somatostatin used adults neuroendocrine tumours;...
Bone loss in anorexia nervosa and following bariatric surgery is associated with an elevated circulating concentration of the gastrointestinal, anorexigenic hormone, peptide YY (PYY). Selective deletion PYY receptor Y1R osteoblasts or Y2R hypothalamus results high bone mass, but mice has resulted conflicting skeletal phenotypes leading to uncertainty regarding its role regulation mass. As analogs are under development for treatment obesity, we aimed clarify relationship between mass.The...
DNA fingerprinting is a tool for plant breeder rights protection, and variety registration in Plant Breeder Rights Repository.In the present study, we developed profile of 12 potato cultivars grown Punjab Pakistan using 214 informative Simple Sequence Repeat (SSR) markers.A total 1720 alleles were amplified by SSR with an average 8.04 per marker.Approximately 72% (1329 alleles) polymorphic 6.88 marker.The number ranged from 1 to 31.Similarly, marker 0 24.A maximum reported IBR13 Polymorphic...
Introduction: Congenital hyperinsulinism (CHI) is a rare condition which leads to unregulated insulin secretion causing hyperinsulinemic hypoglycemia. At present, genetic abnormalities in nine different genes have been described lead secretion. Typically CHI presents the newborn period but it can present infancy and childhood. The hypoglycemia usually severe brain damage if not managed appropriately. histological level, there are two major subtypes of CHI, namely focal diffuse. management...