A5037505875- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Diabetes Management and Research
- Neuroblastoma Research and Treatments
- Multiple Myeloma Research and Treatments
- Neuroendocrine Tumor Research Advances
- Diabetes Treatment and Management
- Health Systems, Economic Evaluations, Quality of Life
- CAR-T cell therapy research
- Cancer, Hypoxia, and Metabolism
- Diabetes and associated disorders
- Acute Lymphoblastic Leukemia research
- Cardiac and Coronary Surgery Techniques
- Healthcare Policy and Management
- Cancer Treatment and Pharmacology
- Cardiovascular Syncope and Autonomic Disorders
- Medical Imaging Techniques and Applications
- Primary Care and Health Outcomes
- Pancreatic function and diabetes
- Hematopoietic Stem Cell Transplantation
- Pharmaceutical Economics and Policy
- Statistical Methods in Clinical Trials
- Immune Cell Function and Interaction
- Metabolism, Diabetes, and Cancer
- Adolescent and Pediatric Healthcare
- Neonatal Respiratory Health Research
European Federation of Allergy and Airways Diseases Patients Associations
2021-2025
Great Ormond Street Hospital for Children NHS Foundation Trust
2018-2023
Great Ormond Street Hospital
2013-2023
University College London
2013-2023
Merck Serono (Switzerland)
2020-2022
University of Newcastle Australia
2018-2022
Merck (United Kingdom)
2022
Myeloma UK
2012-2022
Aneurin Bevan University Health Board
2022
Creative Commons
2022
Background: Investigational and marketed drugs for the treatment of multiple myeloma (MM) are associated with a range characteristics uncertainties regarding long term side-effects efficacy. This raises questions about what matters most to patients living this disease. study aimed understand which MM find important, hence should be included as attributes levels in subsequent quantitative preference survey among patients. Methods: qualitative involved: (i) scoping literature review, (ii)...
Pediatric behavioral health admissions to children's hospitals for disposition planning are steadily increasing. These children may exhibit violent behaviors, which can escalate application of physical limb restraints safety. Using quality improvement methodology, we sought decrease restraint use on admitted our hospital conditions from a baseline mean 2.6% patient days <1%.We included all ≥3 years age medicine service with primary diagnosis July 1, 2016, February 2020. A multidisciplinary...
Multiple myeloma (MM) is a progressive plasma cell malignancy, with range of clinical features including bone lesions, renal insufficiency, anaemia, and hypercalcaemia. Novel agents have significantly improved patient survival, however most patients will suffer multiple relapses. Although challenges economic costs relapse are recognised, the psychological impact not fully appreciated. Additionally, there little information on how physicians perceive their patients' emotional state this might...
Previous research into the parenting task has demonstrated that behavioural difficulties in children are associated with poorer psychological well-being and less sensitive on part of birth parents. However, there been little examining whether this situation applies to foster carers. This study by Kate Morgan Rachel Baron explores relationship between looked after young people's stress, anxiety depression experienced their In addition, parental self-efficacy is considered as a mediator...
<b><i>Background:</i></b> The p.R63W mutation in the hepatocyte nuclear factor-4 alpha<i> (HNF4A)</i> results macrosomia and atypical Fanconi syndrome, addition to hyperinsulinaemic hypoglycaemia (HI). We describe 2 infants carrying this mutation, presenting with additional features. <b><i>Cases Series:</i></b> Patient 1, a male born birth weight of 1.7 SDS, was diagnosed HI on day life. He responded 3-10 mg/kg/day diazoxide. Raised...
Congenital hyperinsulinism (CHI) is a common cause of hypoglycaemia due to unregulated insulin secretion from pancreatic β cells. Medical management includes use oral diazoxide (a K<sub>ATP</sub> channel agonist) and daily injectable octreotide (somatostatin analogue) therapy. However, associated with severe sideeffects such as coarse facies, hypertrichosis psychosocial/compliance issues in adolescents. Lanreotide long-acting somatostatin used adults neuroendocrine tumours;...
such evaluations is an important justification for a modelling approach.Emergency admissions are, by their nature, stochastic and difficult to predict.Our model shows that spare capacity essential if emergency service operate efficiently at level of risk acceptable patients.Emergency admission crises are not generally created poor management.With insufficient bed even the best run hospital risk.It must be recognised NHS maintaining some unoccupied staffed beds wasteful, but cost which...
A long-acting somatostatin analogue (lanreotide) is used in the management of a diazoxide-unresponsive diffuse form congenital hyperinsulinism (CHI). However, no reports its use patients with focal CHI exist. Case 1: 1-month-old boy diagnosed due to paternal heterozygous ABCC8 gene mutation showed partial response octreotide. 18F-DOPA-PET/CT scan revealed lesion pancreatic head. Surgical removal was unsuccessful. He switched monthly lanreotide treatment at age 11 months, which stabilised his...
The financial impact of the rising number pediatric mental health hospitalizations is unknown. Therefore, this study assessed costs, reimbursements, and net profits or losses for 111,705 non–mental medical in children's hospitals with use Pediatric Health Information System Revenue Management Program. Average margins were calculated as (reimbursement per day) – (cost day), they lowest ($136/day), next suicide attempt ($518/day), highest other ($611/day). For 10 17 hospitals, margin day was...
Continuous glucose monitoring (CGM) is the standard of care for in children with diabetes, however there are limited data reporting their use hyperinsulinaemic hypoglycaemia (HH). Here, we evaluate CGM accuracy and its impact on quality life HH. Real-time (Dexcom G5 G6) was used HH aged 0-16years. Data from self-monitoring capillary blood (CBG) were collected over a period up to 28days analysed. Quality assessed by PedsQL4.0 general module PedsQL2.0 family module, completed parents/carers...
Purpose: To provide real-world data on patient perceptions and experiences with subcutaneous (SC) versus intravenous (IV) daratumumab.Patients Methods: This was a cross-sectional, mixed-method (qualitative/quantitative) survey conducted in France, Germany, Spain the United Kingdom involving multiple myeloma (MM) patients who switched from IV to SC daratumumab last 12 months (qualitative phase) or 24 (quantitative phase [26 UK]) prior enrollment study.Results: Nine (mean age 65 years)...
Abstract Context In focal congenital hyperinsulinism (CHI), localized clonal expansion of pancreatic β-cells causes excess insulin secretion and severe hypoglycemia. Surgery is curative, but not all lesions are amenable to surgery. Objective We describe surgical nonsurgical outcomes CHI in a national cohort. Methods Patients with were retrospectively reviewed at 2 specialist centers, 2003-2018. Results Of 59 patients CHI, 57 had heterozygous mutations ABCC8/KCNJ11 (51 paternally inherited, 6...
Given the rapid increase in novel treatments for patients with multiple myeloma (MM), this patient preference study aimed to establish which treatment attributes matter most MM and evaluate discrete choice experiment (DCE) swing weighting (SW) as two elicitation methods quantifying patients' preferences.A survey incorporating DCE SW was disseminated among European patients. The included levels informed by a previous qualitative 24 Latent class mixed logit models were used estimate attribute...
An 81-year-old woman who had a long-term silicone suprapubic catheter (SPC) presented to hospital-few hours following routine change of the in community-reporting drainage faeculent matter.The patient was clinically well.A suspicion colovesical fistula raised and CT scan abdomen pelvis carried out.The latter showed that SPC situated entirely outside bladder with tip located inside descending colon (figures 1 2).Studying images it became apparent not entered bladder's cavity but rather eroded...
<b><i>Background:</i></b> Mutations of the insulin receptor (INSR) gene lead to a wide spectrum inherited resistance (IR) syndromes. Among these, type A-IR, usually caused by dominant negative <i>INSR</i> mutations, generally presents peri-pubertally in girls. <b><i>Case:</i></b> A 2.8-year-old girl was referred due recurrent postprandial and fasting hypoglycemia. She had been born at full-term with birth weight 1.89 kg, developed...
Post-prandial hyperinsulinaemic hypoglycaemia (PPHH) is a recognized complication of various gastric surgeries in children, but rarely reported after oesophageal atresia repair. We report 2 children diagnosed with PPHH surgery and the challenges their management. Case 1: A 2-year-old boy at birth was surgically repaired requiring 6 dilatations first year life. At 11 months age, he manifested hypoglycaemic seizures investigations confirmed PPHH. Acarbose diazoxide trials failed. He managed...