A5032214119- Synthesis and biological activity
- Research in Cotton Cultivation
- Pesticide and Herbicide Environmental Studies
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Weed Control and Herbicide Applications
- Fungal Plant Pathogen Control
- Phenothiazines and Benzothiazines Synthesis and Activities
- Cholinesterase and Neurodegenerative Diseases
- Plant Gene Expression Analysis
- Allelopathy and phytotoxic interactions
- Quinazolinone synthesis and applications
- Computational Drug Discovery Methods
- Synthesis of Organic Compounds
- Diabetes Treatment and Management
- Plant Virus Research Studies
- Synthesis and Biological Evaluation
- Receptor Mechanisms and Signaling
- Insect and Pesticide Research
- Multicomponent Synthesis of Heterocycles
- Neuroscience and Neuropharmacology Research
- Plant biochemistry and biosynthesis
- Genomics and Phylogenetic Studies
- Molecular Sensors and Ion Detection
- Treatment of Major Depression
Liaocheng University
2017-2025
Peking University
2025
Peking University Cancer Hospital
2025
Inner Mongolia Medical University
2025
Shandong University
2024
The University of Texas MD Anderson Cancer Center
2024
Zhengzhou University
2023
Nankai University
2015-2020
Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine
2017-2020
Cotton Research Institute
2017-2019
Allogeneic chimeric antigen receptor T (CAR-T) therapy, also known as universal CAR-T (UCAR-T) offers broad applicability, high production efficiency, and reduced costs, enabling quicker access for patients. However, clinical application remains limited by challenges such immune rejection, issues with potency durability. We first screened a safe effective anti-CD70 scFv to construct cells. Anti-CD70 UCAR-T cells were then generated knocking out TRAC, B2M, HLA-DRA. To address the limitations...
To develop aryloxyphenoxypropionate herbicides with a novel structure and improved activity, total of 39 aryloxyphenoxypropionate/amide derivatives containing quinazolinone moiety were synthesized further bioevaluated. The bioassay results in the greenhouse showed that most target compounds had good herbicidal activity under postemergence conditions, which, QPP-I-6 displayed excellent against Echinochloa crusgalli, Digitaria sanguinalis, Spartina alterniflora, Eleusine indica, Pennisetum...
In continuation of our efforts to identify novel herbicide lead compounds with enhanced activity, a series eighteen 5-acylbarbituric acid derivatives containing pyrimidinedione moiety were designed and synthesized. Their herbicidal activities subsequently evaluated in the greenhouse. Bioassay results demonstrated that most newly synthesized exhibited significant efficacy at dosage 150 g ha−1, BA-I-2, BA-II-2, BA-III-2, BA-III-5 achieving complete inhibition tested weeds. Further...
Upland cotton (Gossypium hirsutum) is grown for its elite fiber. Understanding differential gene expression patterns during fiber development will help to identify genes associated with quality. In this study, we used two recombinant inbred lines (RILs) differing in quality derived from an intra-hirsutum population explore profiling differences and high-quality or specific fiber-development stages using RNA sequencing. Overall, 72/27, 1137/1584, 437/393, 1019/184, 2555/1479 differentially...
Cytokinins are one of the five major hormones families in plants and important for their normal growth environmental adaptability. In plants, cytokinins mostly present as glycosides glycosylation modifications catalyzed by family 1 glycosyltransferases. Current research on cytokinin has focused biochemical identification enzymes analysis metabolites Arabidopsis. There few studies that examine how affects its synthesis accumulation plants. It is particularly to understand these processes food...
In order to develop a novel herbicide containing the β-triketone motif, series of 4-hydroxyl-3-(2-phenoxyacetyl)-pyran-2-one derivatives were designed and synthesized. The bioassay results showed that compound II15 had good pre-emergent herbicidal activity even at dosage 187.5 g ha–1. Moreover, broader spectrum weed control when compared with commercial 2,4-dichlorophenoxyacetic acid (2,4-D), displayed crop safety Triticum aestivum L. Zea mays Linn. applied 375 ha–1 under pre-emergence...
In this study, a series of coumarin derivatives were designed and synthesized, their structures characterized using nuclear magnetic resonance (NMR) high-resolution mass spectrometry (HRMS) testing methods. the pharmacological experiment, two behavior-monitoring methods, forced swim test (FST) tail suspension (TST), used to determine antidepressant activity derivatives. Compounds that showed potential analyzed for effects on 5-hydroxytryptamine (5-HT) levels in brains mice. Molecular docking...
Nicosulfuron, an acetolactate synthase (ALS) inhibitor herbicide, is a broad-spectrum and highly effective post-emergence herbicide. Glycosyltransferases (GTs) are widely found in organisms transfer sugar molecules from donors to acceptors form glycosides or esters, thereby altering the physicochemical properties of acceptor molecule, such as participating detoxification. In this study, nine glycosyltransferases group D apple glycosyltransferase family I were predicted possibly be involved...
In this study, we synthetized a series of 5-aryl-4,5-dihydrotetrazolo[1,5-
Natural products are one of the resources for discovering novel pesticide leads. Here, by molecular hybridization between natural enamino diketone skeleton and reported herbicide lead compound I, a series 3-(1-aminoethylidene)-6-methyl-2H-pyran-2,4(3H)-dione derivatives (APD) were rationally designed, synthesized tested herbicidal activity in greenhouse. The bioassay results showed that most target compounds possessed good under pre-emergence conditions, which analog APD-II-15 displayed...
Abstract A series of 7‐phenyl‐4,5,6,7‐tetrahydrothieno[3,2‐ b ]pyridine derivatives containing triazole and other heterocycle substituents (methyltriazole, tetrazole, triazolone) is described. Two experimental methods, maximal electroshock (MES) subcutaneous pentylenetetrazole (scPTZ), were used to evaluate the anticonvulsant activity target compounds. Moreover, neurotoxicity (NT) was tested using Rotarod test. 5‐(4‐Chlorophenyl)‐4,5‐dihydrothieno[2,3‐ e ][1,2,4]triazolo[4,3‐ a ( 6c ) showed...
Through studying structure, bioassay and soil degradation tri-factor relationship, potential controllable of SU was firstly explored summarized.
The present meta-analysis aimed to evaluate metformin combined with acarbose compared monotherapy either of the two drugs for type 2 diabetes (T2DM). Relevant trials were retrieved through searching PubMed, Embase, Cochrane library, China National Knowledge Infrastructure, Wanfang and Chongqing VIP information network databases. Heterogeneous homogeneous data statistically using a random- fixed-effects model, respectively. For dichotomous continuous data, merged effect size was presented as...