A5101818806- Spinal Fractures and Fixation Techniques
- Scoliosis diagnosis and treatment
- Spine and Intervertebral Disc Pathology
- Plant Pathogenic Bacteria Studies
- Biosensors and Analytical Detection
- Vibrio bacteria research studies
- Aquaculture disease management and microbiota
- Cervical and Thoracic Myelopathy
- Streptococcal Infections and Treatments
- Antibiotic Resistance in Bacteria
- Spinal Dysraphism and Malformations
- Microbial infections and disease research
- Bacterial Identification and Susceptibility Testing
- Spinal Hematomas and Complications
- Enterobacteriaceae and Cronobacter Research
- Congenital heart defects research
- Mycobacterium research and diagnosis
- Soft Robotics and Applications
- Connective tissue disorders research
- Musculoskeletal pain and rehabilitation
- Genetic factors in colorectal cancer
- Infections and bacterial resistance
- Medical Imaging and Analysis
- Pelvic and Acetabular Injuries
- Spinal Cord Injury Research
Zhejiang Center for Disease Control and Prevention
2025
Jiangxi Pingxiang People's Hospital
2025
Chinese Center For Disease Control and Prevention
2020-2024
National Institute for Communicable Disease Control and Prevention
2020-2024
The Third Affiliated Hospital of Zhejiang Chinese Medical University
2024
Zhejiang Chinese Medical University
2024
State Key Laboratory of Infectious Disease Prevention and Control
2020-2023
Meta (United States)
2023
Carnegie Mellon University
2023
Google (United States)
2023
Background Early-onset scoliosis (EOS), defined by an onset age of less than 10 years, conveys significant health risk to affected children. Identification the molecular aetiology underlying patients with EOS could provide valuable information for both clinical management and prenatal screening. Methods In this study, we consecutively recruited a cohort 447 Chinese operative EOS. We performed exome sequencing (ES) screening on these individuals their available family members (totaling 670...
Study Design. A case-control association study was performed to investigate the relationship between ladybird homeobox (LBX1) and adolescent idiopathic scoliosis (AIS) in northern Chinese Han population. Objective. To explore prevalence functional importance of LBX1 polymorphisms patients with AIS within Summary Background Data. is most common subtype scoliosis. Genetic factors such as have been recently proved be associated some populations. In this we explored around Methods. Five tag...
Percutaneous endoscopic transforaminal discectomy (PETD) is regarded as a viable alternative option for upper lumbar disc herniation (LDH). However, few studies have evaluated PETD LDH, and no study has compared the advantages of procedures versus conventional surgery. The present was aimed at comparing surgical outcome safety open in treatment LDH.Data from 42 patients treated LDH July 2015 to 2018 were retrospectively analyzed, including 21 with (PETD group) posterior (open group). two...
Aeromonas is widely distributed in aquatic environments. This study describes the pathogenic characteristics of isolated from adult diarrhea patients and environments Beijing, China. isolates with river water samples were assessed using whole-genome sequencing (WGS) antibiotic resistance profiling. In total, 38 collected. Among these, 13 common clinical symptoms, including diarrhea, abdominal pain, nausea. Four Aeromonas-positive co-infected other intestinal pathogens. Patient-derived showed...
CTX-M-type extended-spectrum beta-lactamases (ESBLs) have shown a high level of global transmission, with limited systematic understanding their epidemic patterns in China. A comprehensive analysis covering 1974-2023 identified 133 (3.2%) blaCTX-Ms-producing strains among 4146 from 25 Chinese cities across 82 genera were performed. Integrating public database (n=431), the study comprised 564 blaCTX-Ms-positive isolates sourced 19 provinces (1986-2022) including 300 (53.2%) clinical and 228...
To investigate short-term effectiveness of using expert adolescent lateral femoral nail (EALFN) in treating shaft fractures older children and adolescents. A retrospective analysis was conducted on the clinical data 17 patients with who met inclusion criteria were admitted between July 2020 June 2024. All fixed EALFN after reduction. There 11 males 6 females, a mean age 13.3 years (range, 11-16 years). The average body weight 51.2 kg 40-84 kg), height 162.1 cm 150-172 cm). causes injury...
Introduction Shewanella is an important opportunistic pathogen distributed in marine environments that has caused increasing number of clinical infections. However, there are few reports on the distribution and characteristics diarrheal spectrum. In this study, we have systematically described prevalence infections diarrhea patients Beijing, China 2017–2019, genome antimicrobial susceptibility isolates. Methods Stool samples were collected from a surveillance project 2017 to 2019. strains...
Low back pain (LBP) is a common health problem and many LBP are caused by lumbar disc degeneration (LDD). ADAMTS-4 (a disintegrin metalloprotease with thrombospondin motifs-4), also known as aggrecanse-1, plays core role in of extracellular matrix LDD. To investigate the association between genetic polymorphism LDD, we genotyped SNPs around ADAMTS-4. We recruited 482 sporadic cases LDD 496 healthy controls from Chinese Han population. Five were selected phenotyped Sequenom MassARRAY system....
Shewanella species are widely distributed in the aquatic environment and organisms. They opportunistic human pathogens with increasing clinical infections reported recent years. However, there is a lack of rapid accurate method to identify species. We evaluated here matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) for identification Shewanella. A peptide reference spectra (PMRS) database was constructed type strains 36 The main spectrum projection...
Brevundimonas spp., a group of bacteria from the family Caulobacteraceae , is associated with nosocomial infections, deserve widespread attention. Our study elucidated genes potentially pathogenicity genus.
Staphylococcus spp., especially aureus (S. aureus), is an important pathogen in hospital-acquired infection and food poisoning. Here, we developed a multienzyme isothermal rapid amplification combined with duplex quantitative PCR (duplex MIRA-qPCR) method, which can simultaneously detect the S. species-specific conserved gene FMN-bgsfp genus-specific tuf. This assay enabled of DNA within 20 min at constant temperature 39 °C. Specificity analysis indicated that all nine common species were...
A rising incidence of clinical infections has been caused by Kluyvera, a significant opportunistic pathogen. Meanwhile, Kluyvera acts as an important reservoir blaCTX-Ms, which are the dominant genes class extended-spectrum β-lactamases (ESBLs). In this work, 60 strains were subjected to phylogenetic relationship reconstruction, antimicrobial susceptibility testing, and antibiotic resistance prediction. All mature blaCTX-Ms gathered perform subgroup reclassification. The findings demonstrate...
In Brief Study Design. Comparison of 2 radiographic scoliosis classification systems by multiple surgeons. Objective. Compare the reliability Peking Union Medical College (PUMC) and Lenke analyze their differences. Summary Background Data. The PUMC is a newly reported system based on measurements with recent popularity, while widely accepted worldwide in surgical design. Both these have own individual characteristics, hence it necessary to compare reliability. Methods. Five surgeons...
In this work, we present a novel approach for Chinese Ink-and-Wash style transfer using GAN structure. The proposed method incorporates specially designed smooth loss tailored task, and an end-to-end framework that seamlessly integrates various components efficient effective image transferring. To demonstrate the superiority of our approach, comparative results against other popular methods such as CycleGAN is presented. experimentation showcased notable improvements achieved with in terms...
Minimally invasive procedures are rapidly growing in popularity thanks to advancements medical robots, visual navigation and space registration techniques. This paper presents a precise efficient targeting method for robot-assisted percutaneous needle placement under C-arm fluoroscopy. In this method, special end-effector was constructed perform fluoroscopy calibration robot image-space simultaneously. addition, formulations were given compute the movement of evaluate accuracy using only one...
Vibrio metschnikovii is an emergent pathogen that causes human infections which may be fatal. However, the phylogenetic characteristics and pathogenicity determinants of V. are poorly understood. Here, whole-genome features 103 strains isolated from different sources described. On analysis populations could divided into two major lineages, defined as lineage 1 (L1) 2 (L2), L1 was more likely to associated with activity. Meanwhile, we 29 O-genotypes (VMOg, named VMOg1-VMOg29) by O-antigen...
To understand the characteristics of Vibrio isolates in aquatic environments China and their public health significance, this study investigated water samples six cities 2020. A total 88 sampling locations were included identified 81 them. 143 belonging to 16 species selected for characterization. The population structure showed great differences among cities, indicating regional specificity. presence virulence genes was examined (n = 78) five pathogenic species. All except one 77) contained...
Introduction Kluyvera is a Gram-negative, flagellated, motile bacillus within the Enterobacteriaceae . The case reports of clinical infections shed light on importance this organism as an emerging opportunistic pathogen. genus Phytobacter , which often be misidentified with also important clinically relevant member However, identification and problematic, their phylogenetic relationship remains unclear. Methods Here, 81 strains 16 were collected. A series comparative genomics approaches...
Background: The natural history of split spinal cord malformation (SCM) is still unclear. Knowledge the characteristics osseous spur and its relationship with deformity may allow early identification patients a higher risk neurological deficit enhance surgical decision-making. Methods: Eighty-five consecutive congenital scoliosis type-I SCM who had undergone treatment at our hospital from May 2000 to December 2013 were identified retrospectively. There 22 male 63 female an average age 13.9...
Abstract Background Percutaneous kyphoplasty (PKP) has become an important minimally invasive surgical technique for fracture stabilization and pain relief in patients with vertebral compression fractures. However, intraspinal cement leakage following PKP is a serious postoperative complication that can lead to morbidity mortality. Case presentation We describe uncommon case of epidural bone 81-year-old woman who underwent posterior lumbar decompression fusion from L3–5 4 years prior had...
Abstract Background Members of the genus Proteus are mostly opportunistic pathogens that cause a variety infections in humans. The molecular evolutionary characteristics and genetic relationships among species have not been elucidated to date. In this study, we developed multilocus sequence analysis (MLSA) approach based on five housekeeping genes (HKGs) delineate phylogenetic within . Results Of all 223 strains collected current tree concatenated HKGs ( dnaJ, mdh, pyrC, recA rpoD ) divided...
Study Design. A retrospective analysis (2015–2019) of data collected from patients who underwent posterior lumbar spinal surgery. Objective. This study aims to identify the incidence, perioperative hematological characteristics, potential prognostic indicators, and risk factors deep venous thrombosis (DVT) in lower limbs after Eliminating or taking measures against at may reduce incidence DVT. Summary Background Data. Deep thromboses have been extensively studied other reconstructive...