A5100416025- Wound Healing and Treatments
- Cancer, Stress, Anesthesia, and Immune Response
- Spine and Intervertebral Disc Pathology
- Musculoskeletal pain and rehabilitation
- Lung Cancer Treatments and Mutations
- Inflammatory mediators and NSAID effects
- RNA Interference and Gene Delivery
- Diabetic Foot Ulcer Assessment and Management
- Hearing, Cochlea, Tinnitus, Genetics
- Cancer-related molecular mechanisms research
- COVID-19 Clinical Research Studies
- Oil and Gas Production Techniques
- Kawasaki Disease and Coronary Complications
- Dermatology and Skin Diseases
- Nitric Oxide and Endothelin Effects
- Estrogen and related hormone effects
- Long-Term Effects of COVID-19
- Monoclonal and Polyclonal Antibodies Research
- Anesthesia and Pain Management
- Fungal Biology and Applications
- Flavonoids in Medical Research
- Inflammasome and immune disorders
- Ion Channels and Receptors
- Sirtuins and Resveratrol in Medicine
- Synthesis and Biological Evaluation
Xi'an Medical University
2023-2024
Naval University of Engineering
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2014-2024
Anhui Medical University
2020-2024
Air Force Medical University
2024
Xijing Hospital
2024
Sichuan University
2024
West China Second University Hospital of Sichuan University
2024
Peking Union Medical College Hospital
2014-2024
First Affiliated Hospital of Anhui Medical University
2020-2024
With the advent of genomics era, heterologous gene expression has been used extensively as a means accessing natural products (NPs) from environmental DNA samples. However, production NPs often very low efficiency or is unable to produce targeted NPs. Moreover, due complicated transcriptional and metabolic regulation NP biosynthesis in native producers, especially cases genome mining, it also difficult rationally systematically engineer synthetic pathways improved biosynthetic efficiency. In...
Phytosterols are widely present in vegetable oils, nuts, cereal products, fruits, and berries. Phytosterol-induced treatment sensitivity has recently shed light on alleviating multidrug resistance cancer therapy. Here, we demonstrated that β-sitosterol, the most common dietary phytosterol, recovers oxaliplatin (OXA) drug-resistant colorectal (CRC) cells by inhibiting breast protein (BCRP) expression. We further showed evidence β-sitosterol could activate p53 disrupting p53–MDM2 interaction,...
Reactive oxygen species (ROS) play essential roles in the pulmonary vascular remodelling associated with hypoxia-induced hypertension (PH). Vascular peroxidase 1 (VPO1) is a newly identified haeme-containing that accelerates oxidative stress development vasculature. This study aimed to determine potential role of VPO1 PH-related remodelling.The morphology and expression were assessed arteries Sprague-Dawley (SD) rats. Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 4 (NOX4) HOCl...
Chronic prostatitis and chronic pelvic pain syndrome (CP/CPPS) is a complicated characterized by genitourinary in the absence of bacterial infection. Th17 cell-driven autoimmunity has been proposed as cause CP/CPPS. However, factors that promote Th17-driven experimental autoimmune (EAP) molecular mechanisms are still largely unknown. Here, we showed cells were excessively activated, blockade IL-17A could effectively ameliorate various symptoms EAP. Furthermore, revealed...
Baicalin is a naturally occurring compound with anticancer, antioxidant, and anti-inflammatory properties. However, the mechanism underlying its anticancer activity on nonsmall cell lung cancer (NSCLC) remains unclear.The effects of baicalin progression metastasis experimental NSCLC lines were studied in vitro vivo. Wound-healing transwell assays performed to evaluate potency motility migration ability NCI-H460 cells. Immunofluorescence assay, western blot immunohistochemistry test conducted...
Low back pain (LBP) is a common health problem and many LBP are caused by lumbar disc degeneration (LDD). ADAMTS-4 (a disintegrin metalloprotease with thrombospondin motifs-4), also known as aggrecanse-1, plays core role in of extracellular matrix LDD. To investigate the association between genetic polymorphism LDD, we genotyped SNPs around ADAMTS-4. We recruited 482 sporadic cases LDD 496 healthy controls from Chinese Han population. Five were selected phenotyped Sequenom MassARRAY system....
Kawasaki disease (KD) is a childhood systemic vasculitis that exhibits specific preference for the coronary arteries. The aetiology remains unknown and there are no especially diagnostic tests. microRNAs (miRNAs) 18 to 23 nucleotides non-coding RNAs negative regulator of gene expression play crucial role in regulatory network genome. Recently, circulating miRNAs have been found presentation human plasma displayed some characteristics ideal biomarker. However, few researches explored...
Renal fibrosis is a common and characteristic symptom of chronic kidney disease (CKD). However, the molecular mechanisms renal remain elusive. Ischemia injury, as major cause AKI, deserves more attention in order to improve knowledge AKI-induced fibrosis. Transforming growth factor-β (TGF-β)-activated kinase 1 (TAK1) interacts directly with TGF-β, which play critical role progression Therefore, present study aimed investigate TAK1 pathogenesis ischemia-induced Compared mice vehicle group,...
To investigate adverse events(ADEs) associated with the use of paracetamol and ibuprofen in people under 18 years age.
Short-circuit blowing is a crucial technical approach for ensuring the rapid surfacing of submersibles. In order to investigate law, L18(37) orthogonal experiments based on proportional short-circuit model test bench were conducted. Subsequently, Back Propagation Neural Network (BPNN) and Pearson correlation analysis employed train experimental data; further examination between individual factors served as an enhancement experiments. It has been proved that both multi-factor combinations...
The aim of this study was to evaluate how CYP2C19 affects icotinib and metabolite' exposure, determine whether the exposure EGFR genotype influences survival time, tumor metastasis adverse drug reactions.274 NSCLC patients who accepted 125 mg icotinib/t.i.d. were chosen from a phase III study. Blood samples obtained in 672 nd (4th week) 1,680 th hours (10th week), plasma used quantify concentration blood cells sampled check genotypes. Clinical data also collected at same including Plasma...
This study aims to clarify if apigenin (AP) could play a pivotal role in attenuating acrylonitrile (ACN)-induced sperm and testis injury by inhibiting ASK1-JNK/p38 signaling pathway. Male Sprague-Dawley rats were randomly divided into five groups: control group (corn oil), an ACN (ACN 46 mg kg-1), + AP1 AP 117 AP2 234 kg-1) AP3 351 kg-1). The groups given gavage after pretreatment with different dosages of for 30 min, whereas the received equivalent volume corn oil. was conducted 6 days per...
Common chronic wounds include diabetic ulcers, venous and pressure ulcers. The traditional Chinese medicine Huiyang Shengji decoction (HYSJD) has been shown to promote the healing of wounds, however, its pharmacological mechanism is still unclear.This study aimed determine HYSJD in promoting skin ulcers.Ultra-performance liquid chromatography was combined with tandem mass spectrometry (UPLC-MS/MS) analyze main components absorbed mouse serum at 30 min after oral administration HYSJD. db/db...
Intrauterine adhesions (IUAs) are a common illness of the uterine cavity. Endometrial fibrosis is main pathological feature. In addition to high recurrence rate, patients with severe IUAs have low pregnancy rate. However, there few effective treatments for IUAs. This study aims confirm influence apoptotic bodies bone marrow mesenchymal stem cells (BMSCs) on endometrial stromal cell by mediating Wnt/β-catenin signaling pathway and provide new insight clinical treatment IUAs.Human (HESCs) were...
The active components and mechanisms of tea cake extract (TCE) were investigated for treating cough. TCE tentatively identified by ultrahigh-performance liquid chromatography coupled with Q-Exactive MS/MS (UPLC-QE-MS/MS), whose targets obtained from the Swiss Target Prediction database Traditional Chinese Medicine Systems Pharmacology analysis platform. Cough-related retrieved Gene Cards Online Mendelian Inheritance in Man database. After intersection had been obtained, enrichment Ontology...