A5033097876- Peptidase Inhibition and Analysis
- Protease and Inhibitor Mechanisms
- Genetic and Kidney Cyst Diseases
- Fungal Biology and Applications
- Renal Diseases and Glomerulopathies
- Chronic Kidney Disease and Diabetes
- Neuropeptides and Animal Physiology
- Ubiquitin and proteasome pathways
- Renal and related cancers
- RNA Interference and Gene Delivery
- Adipokines, Inflammation, and Metabolic Diseases
- Synthesis and Characterization of Heterocyclic Compounds
- Advanced Glycation End Products research
- Prostate Cancer Treatment and Research
- PI3K/AKT/mTOR signaling in cancer
- Chronic Myeloid Leukemia Treatments
- Medicinal Plants and Bioactive Compounds
- Regulation of Appetite and Obesity
- Synthesis and biological activity
- Retinoids in leukemia and cellular processes
- Cardiovascular Health and Disease Prevention
- Hedgehog Signaling Pathway Studies
- Connective Tissue Growth Factor Research
- Non-Invasive Vital Sign Monitoring
- Hormonal and reproductive studies
Cornell University
2004-2024
Bozhou People's Hospital
2024
Stamford International University
2024
Macao Polytechnic University
2024
Baoshan College
2024
Longhua Hospital Shanghai University of Traditional Chinese Medicine
2011-2023
Shanghai University of Traditional Chinese Medicine
2011-2023
Central South University
2019-2023
Ocean University of China
2023
Lanzhou University
2005-2021
This paper investigates the capacity of ChatGPT, an advanced language model created by OpenAI, to mitigate side effects encountered learners in Personal Learning Environments (PLEs) within higher education. A series semi-structured interviews were conducted with six professors and three Information Communication Technology (ICT) experts. Employing thematic analysis, interview data assessed, revealing that stemming from learner learning perspectives could be primarily categorized into...
Puerarin, an active compound of radix puerariae, is a major used in Chinese herbal medicines to treat patients with diabetic nephropathy (DN). In the previous studies, we showed that puerarin exerts renoprotective effects Streptozocin (STZ)-induced mice through activation Sirt1 and anti-oxidative effects. Here, further investigated underlying mechanism mediating renal protective DN. We studied STZ-induced cultured immortalized mouse podocytes treated high glucose. confirmed ameliorated...
Leptin, an adipocyte derived cytokine that is closely associated with obesity, was recently shown to be involved in carcinogenesis and cancer progression. Because obesity a significant risk factor for renal cell carcinoma, we investigated the link between leptin development of carcinoma.Associations preoperative serum levels receptor expression tumor specimens various clinicopathological parameters were analyzed 57 patients carcinoma.Serum 1.2 16.2 ng/ml (mean 4.5). Of tumors 22 (38.6%)...
Membranous nephropathy (MN) is the most common cause of idiopathic nephrotic syndrome in adults and known to be due injury podocytes located glomeruli. Astragalus membranaceus has been used for treatment patients with MN China a long time. The beneficial effect on proteinuria well documented. However, mechanism astragalus membranaceu alleviation still not completely understood. Therefore, current study, we employed podocyte model induced by complement membranous attack complex examine...
Renal interstitial fibrosis is characterized by inflammation and an excessive accumulation of extracellular matrix, which leads to end-stage renal failure. Our previous studies have shown that a natural product from Cordyceps cicadae can ameliorate chronic kidney diseases. N6-(2-Hydroxyethyl) adenosine (HEA), physiologically active compound in C. cicadae, has been identified as Ca2+ antagonist anti-inflammatory agent pharmacological tests. However, its role the underlying mechanism remains...
The neurofibromatosis 2 (NF2) tumor suppressor gene product merlin is an important regulator of contact-dependent cell proliferation. Phosphorylation at serine 518 (Ser518) by the Rac effector p21-activated kinase (PAK) inactivates merlin's growth suppressing function, and regulated cell-culture conditions, including density, cell/substrate attachment, factor availability. We examined regulation expression phosphorylation in prostate cancer cells.Phosphorylation five lines (LNCaP, DU145,...
The main functional components of green tea, such as epigallocatechin gallate (EGCG), (EGC), epicatechin (ECG) and (EC), are found to have a broad antineoplastic activity. discovery their targets plays an important role in revealing the mechanism. Therefore, identify potential target proteins for tea polyphenols, we taken comparative virtual screening approach using two reverse docking systems, one based on Autodock software other Tarfisdock. Two separate silico workflows were implemented...
In this study, we developed a radial artery pulse acquisition system based on finger-worn dense pressure sensor arrays to enable three-dimensional signals acquisition. The pressure-sensor were fabricated by packaging 18 ultra-small MEMS sensors (0.4 mm × 0.4 0.2 each) with pitch of 0.65 flexible printed circuit boards. Pulse are measured and recorded simultaneously when traditional Chinese medicine practitioners wear the fingers while palpating pulse. Given that pitches much smaller than...
Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease characterized by inflammation and excessive deposition of extracellular matrix components. Transforming growth factor-β1 (TGF-β1) induced epithelial–mesenchymal transformation type 2 epithelial cells leads to deposition, which plays an important role in fibrosis. Our objective was evaluate the effects 3-cyclopropylmethoxy-4-(difluoromethoxy) benzoic acid (DGM) on aimed determine whether EMT key pathogenesis can be used as...
Obesity is a significant risk factor for renal cell carcinoma. The adipocyte derived cytokine leptin, which controls body weight homeostasis through food intake and energy expenditure, recently provided potential link between obesity cancer development. We examined whether leptin promotes the invasiveness of cells we investigated its underlying signaling pathway.Leptin receptor expression in 6 human lines Caki-1, ACHN, 769P, A498, SKRC44 SKRC49, murine line Renca was by reverse...
Abstract The ∼14 kb mRNA of the polycystic kidney disease gene PKD1 encodes a large (∼460 kDa) protein, termed polycystin‐1 (PC‐1), that is responsible for autosomal dominant (ADPKD). unique organization its multiple adhesive domains (16 Ig‐like domains/PKD domains) suggests it may play an important role in cell–cell/cell–matrix interactions. Here we demonstrated promoted cell–cell and cell–matrix interactions cancer cells, indicating PC‐1 involved cell adhesion process. Furthermore this...
Autosomal recessive polycystic kidney disease (ARPKD) is one of the important genetic disorders in pediatric practice. Mutation and hepatic gene 1 (PKHD1) was identified as cause ARPKD. The encodes a 67-exon transcript for large protein 4074 amino acids termed fibrocystin, but its function remains unknown. neoplastic-like cystic epithelial proliferation epidermal growth factor/epidermal factor receptor (EGF/EGFR) axis overactivity are known most characteristics Since misregulation...
Low response, treatment-related complications and relapse due to the low sensitivity of myelodysplastic syndrome (MDS) leukemia stem cells (LSCs) or pre‑LSCs arsenic trioxide (ATO), represent main problems following treatment with ATO alone in patients MDS. To solve these problems, a chemosensitization agent can be applied increase susceptibility ATO. Curcumin (CUR), which possesses wide range anticancer activities, is commonly used for various types tumors, including hematopoietic...
Abstract Increasing evidence suggests that androgen independent prostate cancer (PC) maintains a functional receptor (AR) pathway despite the low levels of circulating following withdrawal, molecular mechanisms which are not well defined yet. To address this question, we investigated effects endothelin‐1 (ET‐1) on AR expression. Western analysis and RT‐PCR revealed in presence ET‐1, significantly increased time‐ dose‐dependent manner LNCaP cells. Pretreatments with inhibitors Src...
The screening for illegal adulteration of glucocorticoids (GCs) in cosmetics is challenging due to the vast variety potential GCs that are present improve declared effects. An effective analytical method screen illegally added vital protect consumers.An ultra-performance liquid chromatography/tandem mass spectrometry (UPLC/MS/MS) using precursor ion scanning (PIS) acquisition mode was developed cosmetics. Forty-seven were investigated identify their common product ions formed by...
Abstract Studies have shown that polycystin‐1, encoded by PKD1, the major ADPKD, may a central role in regulating both apoptosis and proliferation, which could prevent malignant transformation of affected cells. However, as putative tumor suppressor, direct studies on possibility polycystin‐1 play cancer cells' biological properties not yet been reported. We demonstrated cells was induced overexpression polycystin‐1. After transfection with three cell lines, HepG2, A549, SW480, showed...