A5101524195- Kawasaki Disease and Coronary Complications
- Viral Infections and Immunology Research
- Coronary Artery Anomalies
- Inflammasome and immune disorders
- Extracellular vesicles in disease
- interferon and immune responses
- Autophagy in Disease and Therapy
- Cardiovascular Issues in Pregnancy
- Cytomegalovirus and herpesvirus research
- Cardiac Structural Anomalies and Repair
- Blood Coagulation and Thrombosis Mechanisms
- Parkinson's Disease Mechanisms and Treatments
- Autism Spectrum Disorder Research
- Platelet Disorders and Treatments
- Cell death mechanisms and regulation
- Obsessive-Compulsive Spectrum Disorders
- Renal Diseases and Glomerulopathies
- Calcium signaling and nucleotide metabolism
- Toxoplasma gondii Research Studies
- Cardiomyopathy and Myosin Studies
- Cardiac electrophysiology and arrhythmias
- Estrogen and related hormone effects
- Hormonal Regulation and Hypertension
- Neonatal Health and Biochemistry
- Circular RNAs in diseases
Third Xiangya Hospital
2015-2025
Central South University
2015-2025
Beijing Tian Tan Hospital
2023-2024
Capital Medical University
2023-2024
National Clinical Research Center for Digestive Diseases
2023
Xiangya Hospital Central South University
2018
Indiana University School of Medicine
2004-2010
Indiana University – Purdue University Indianapolis
2004-2010
During cardiogenesis, perturbation of a key transition at mid-gestation from cardiac patterning to growth and chamber maturation often leads diverse types congenital heart disease, such as ventricular septal defect (VSD), myocardium noncompaction, hypertrabeculation. This transition, which occurs embryonic day (E) 9.0-9.5 in murine embryos E24-28 human embryos, is crucial for the developing maintain normal function response an increasing hemodynamic load. Although, trabeculation compaction...
Fkbp52 and Fkbp51 are tetratricopeptide repeat proteins found in steroid receptor complexes, is an androgen (AR) target gene. Although vitro studies suggest that regulate hormone binding and/or subcellular trafficking of receptors, the roles vivo have not been extensively investigated. Here, we evaluate their physiological Fkbp52-deficient Fkbp51-deficient mice. males developed defects select reproductive organs (e.g. penile hypospadias prostate dysgenesis but normal testis), pointing to a...
FK506-binding protein 52 (FKBP52) is a tetratricopeptide repeat that associates with steroid receptors in complexes containing heat shock 90. To investigate the role of FKBP52 steroid-regulated physiology, we generated FKBP52-deficient mice. (-/-) females are sterile due to complete failure implantation, process requires estrogen (ER) and progesterone (PR). Because uterus expresses two forms PR, PR-A PR-B, investigated all three as potential targets action. uteri showed normal growth...
Recent studies have found that viral myocarditis (VMC) associated with coxsackievirus B3 (CVB3) causes autophagy activation after infection, but the specific mechanism is not clear. The present study demonstrated phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB)/mammalian target of rapamycin (mTOR) signaling pathway participates in CVB3‑induced autophagy. We light chain 3 (LC3)‑Ⅱ/LC3‑I ratio was increased and p62 p‑mTOR were altered at different times during CVB3 infection. To...
Abstract Coxsackievirus B3 (CVB3) is an important human pathogen linked to cardiac arrhythmias and acute heart failure. CVB3 infection has been reported induce the formation of autophagosomes that support viral replication in host cells. Interestingly, our study shows accumulation during caused by a blockage autophagosome–lysosome fusion rather than induction autophagosome biogenesis. Moreover, decreases transcription translation syntaxin 17 (STX17), SNARE (soluble N...
Hypospadias is a common birth defect in humans, yet its etiology and pattern of onset are largely unknown. Recent studies have shown that male mice with targeted ablation FK506-binding protein-52 (Fkbp52) develop hypospadias, most likely due to actions Fkbp52 as molecular co-chaperone the androgen receptor (AR). Here, we further dissect developmental mechanisms underlie hypospadias Fkbp52-deficient mice. Scanning electron microscopy revealed elevation prepucial swelling led ventral penile...
Viral myocarditis is potentially fatal and lacking a specific treatment. Exosomes secreted by cardiac progenitor cells (CPCs) have emerged as promising tool for cardioprotection repair. In this study, we investigated whether CPCs-derived exosomes (CPCs-Ex) could utilize the mTOR signal pathway to reduce apoptosis in viral myocarditis. vitro, were, respectively, added H9C2 after CVB3 infection detect anti-apoptosis effect of CPCs-Ex. Compared with controls, rate was reduced, accompanied...
Kawasaki disease (KD) is a childhood systemic vasculitis that exhibits specific preference for the coronary arteries. The aetiology remains unknown and there are no especially diagnostic tests. microRNAs (miRNAs) 18 to 23 nucleotides non-coding RNAs negative regulator of gene expression play crucial role in regulatory network genome. Recently, circulating miRNAs have been found presentation human plasma displayed some characteristics ideal biomarker. However, few researches explored...
Abstract Background Neonatal thrombocytopenia is common in preterm and term neonates admitted to neonatal intensive care units. The etiology behind complex. Inherited rare usually results from genetic mutations. Case presentation Here we report a case of twins with severe inherited presented the period who were shown be compound heterozygotes for 2 UDP-N-acetylglucosamine 2-epimerase ( GNE ) gene mutations, c.1351C > T c.1330G T, which novel mutation. Conclusion These two mutations may...
Kawasaki disease (KD) is an acute febrile illness of early childhood. The exact etiology the remains unknown. At present, research on KD mostly limited to susceptibility genes, infections, and immunity. However, correlation between gut microbiota rare.Children with a diagnosis children undergoing physical examination during same period were included. time admission, subjects' peripheral venous blood feces collected. Faecal samples analyzed for bacterial taxonomic content via high-throughput...
Variants of the BTB/POZ domain-containing protein 9 gene (BTBD9) (rs4714156, rs9357271, and rs9296249) serotonin 5-HT-2C receptor (HTR2C) (rs518147 rs3813929) were reported to be associated with Tourette syndrome (TS) in White population recently. To examine association between variants BTBD9 HTR2C genes patients TS among a Chinese Han population, 110 440 sex-matched, age-matched, ethnicity-matched healthy controls underwent sequencing analysis. There was statistically significant variant...
Exosomes are cell‑derived vesicles released from a variety of mammalian cells that involved in cell‑to‑cell signalling. It has been reported cardiac progenitor (CPCs) derived an adult heart one the most promising stem cell types for cardioprotection and repair. The target rapamycin (mTOR) signalling pathway is pivotal regulator CPCs, therefore, CPC‑derived exosomes were used present study to investigate whether it can promote H9C2 growth through protein kinase B (PKB, or Akt)/mTOR pathway....
This work illustrated the mechanism contributing to process of Phosphatidylinostiol 3-kinase (PI3K)/protein kinase B (PKB)/mammalian target rapamycin (mTOR) signaling pathway, which has been demonstrated play an important role in virus-induced apoptosis, contributes Viral Myocarditis (VMC) pathogeneses. We examined expression Bax, Bim, caspase-3, caspase-9, and viral replication after Coxsackievirus B3 (CVB3) infection using mTOR inhibitor PI3K pretreated HeLa cells, respectively. Apoptosis...
Dysregulated cell death machinery and an excessive inflammatory response in Coxsackievirus B3(CVB3)-infected myocarditis are hallmarks of abnormal host response. Complement C4 C3 considered the central components classical activation pathway often participate process early stages virus infection.
Coxsackievirus B3 (CVB3) is a leading cause of viral myocarditis, but no effective treatment strategy against CVB3 available. Viruses lack an inherent metabolic system and thus depend on host cellular metabolism for their benefit. In this study, we observed that enhanced glycolysis in H9c2 rat cardiomyocytes HL-1 mouse cardiomyocytes. Therefore, three key glycolytic enzymes, namely, hexokinase 2 (HK2), muscle phosphofructokinase (PFKM), pyruvate kinase M2 (PKM2), were measured CVB3-infected...
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease, and genetic contributors exert significant role in the complicated pathogenesis. Identification of causes ALS families could be valuable for early diagnosis management. The development potential drugs patients with defects will shed new light on therapy.To identify causative variants three Chinese familial (FALS), reveal pathogenic mechanism look targeted drug ALS.Whole-exome sequencing bioinformatics were used to perform...
Kawasaki disease (KD) is an acute systemic vasculitis complicated by development of coronary artery lesions. PECAM-1 a kind cell adhesion molecule, which plays important role in disease. The relationship between gene polymorphisms and their susceptibility to diseases still unclear. In our study, we examined the 44 KD patients 59 healthy children revealed correlation with without lesions (CAL).