A5024740804- Sperm and Testicular Function
- Nuclear Structure and Function
- Adipose Tissue and Metabolism
- Ubiquitin and proteasome pathways
- Cancer-related molecular mechanisms research
- Renal and related cancers
- RNA Interference and Gene Delivery
- Ovarian cancer diagnosis and treatment
- RNA Research and Splicing
- Receptor Mechanisms and Signaling
- Virus-based gene therapy research
- Stress Responses and Cortisol
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer Mechanisms and Therapy
- Reproductive Biology and Fertility
- Xenotransplantation and immune response
- Cancer-related gene regulation
- Immune Cell Function and Interaction
- Lung Cancer Diagnosis and Treatment
- DNA Repair Mechanisms
- Advanced Breast Cancer Therapies
- Hormonal Regulation and Hypertension
- Radiomics and Machine Learning in Medical Imaging
- RNA modifications and cancer
- Testicular diseases and treatments
Third Xiangya Hospital
2015-2024
Central South University
2015-2024
Soochow University
2024
Hangzhou Medical College
2024
Zhejiang Provincial People's Hospital
2024
Tangshan People's Hospital
2023
Liaoning Provincial People's Hospital
2023
People's Liberation Army No. 150 Hospital
2018-2019
Chinese People's Liberation Army
2018-2019
Shandong Provincial Hospital
2015
Background and Aims Hepatocellular carcinoma (HCC) is associated with high malignancy rates. Recently, a known deacetylase silent information regulator 1 (SIRT1) was discovered in HCC, its presence positively correlated metastasis. N 6 ‐methyladenosine (m A) the most prominent modification, but exact mechanisms on how SIRT1 regulates m A modification to induce hepatocarcinogenesis remain unclear. Approach Results Here we demonstrate that exerts an oncogenic role by down‐regulating fat mass...
Recent studies have found that viral myocarditis (VMC) associated with coxsackievirus B3 (CVB3) causes autophagy activation after infection, but the specific mechanism is not clear. The present study demonstrated phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB)/mammalian target of rapamycin (mTOR) signaling pathway participates in CVB3‑induced autophagy. We light chain 3 (LC3)‑Ⅱ/LC3‑I ratio was increased and p62 p‑mTOR were altered at different times during CVB3 infection. To...
Abstract Long noncoding RNAs (lncRNAs) play a crucial role in progression of bladder urothelial carcinoma (BUC). However, the molecular mechanisms behind this have not been elucidated yet. Here, we found that lncRNA MAFG‐AS1 , which is highly expressed BUC, correlated with aggressive characteristics and poor prognosis BUC. We demonstrate can promote BUC proliferation, invasion, metastasis, epithelial‐mesenchymal transition vitro vivo. Mechanistically, direct binding to Hu antigen R (HuR)...
Long non-coding RNAs (LncRNAs) have been associated with several types of cancer. However, little is known about their role in lung adenocarcinoma (LUAD).LINC00968 was significantly differentially expressed LUAD tissues. Downregulated LINC00968 clinicopathological features LUAD. inhibited cell growth and metastasis by regulating the Hippo signaling pathway We demonstrated that acts as a ceRNA to consume miR-21-5p, enhancing accumulation SMAD7, miR-21-5p target.LINC00968 limits progression...
Background: Invasive lung adenocarcinoma with MPP/SOL components has a poor prognosis and often shows tendency to recurrence metastasis. This may require adjustment of treatment strategies. Preoperative identification is essential for decision-making subsequent treatment. Objective: study aimed preoperatively predict the probability in adenocarcinomas by comprehensive model that includes radiomics features, clinical characteristics, serum tumor biomarkers. Design: A retrospective case...
In the past 10 years, several publications have highlighted role of regulator G protein signalling (RGS) family in multiple diseases, including cardiovascular diseases. As one multifunctional members, RGS14 is involved various biological processes, such as synaptic plasticity, cell division, and phagocytosis. However, diseases remains unclear. present study, we used a genetic approach to examine pathological cardiac remodelling vivo vitro. We observed that was down-regulated human failing...
Polycystic ovarian syndrome (PCOS) is a major severe ovary disorder affecting 5-10% of reproductive women around the world. PCOS can be considered metabolic disease because it often accompanied by obesity and diabetes. Brown adipose tissue (BAT) contains abundant mitochondria adipokines has been proven to effective for treating various diseases. Recently, allotransplanted BAT successfully recovered function rat. However, allotransplantation could not applied human PCOS; most potent from...
SUN domain-containing proteins belong to a novel protein family. To date, several members--SUN1, SUN2, SUN3, and SPAG4--have been identified as nuclear envelope (NE) proteins. In this study, we sought characterize define the potential function of SPAG4L, newly protein. Using bioinformatic analysis, found that SPAG4L contained conserved domain in C-terminal. Subcellular localization analysis indicated expression green fluorescent protein-labeled full-length was localized NE endoplasmic...
Lung cancer is the most common cause of cancer‑related deaths, and early diagnosis targeted therapy are extremely important in treatment this disease. Sperm‑associated antigen 4 (SPAG4) was recently found to be a novel biomarker. In present study, expression SPAG4 revealed high lung adenocarcinoma tissues as determined by western blotting immunohistochemistry. knockdown RNAi efficiently reduced migration A549 cells vitro. Mechanistically, exerted its tumor promoting functions interacting...
Previous studies have determined that CYP3A and multidrug resistance protein 1 (MDR1) polymorphisms can affect the pharmacokinetics pharmacodynamics of amlodipine in both healthy subjects those with early hypertensive renal disease. In current study, our objective was to analyze association between CYP3A4*1G, CYP3A5*3, MDR1 C3435T gene antihypertensive efficacy patients after transplantation. Materials: Blood samples were collected from 76 on therapy (5 mg/d).The genetic detected using...
Acephalic spermatozoa syndrome is a rare genetic and reproductive disease. Recent studies have shown that approximately 33–47% of patients with acephalic SUN5 mutations, but the molecular mechanism underlying this phenomenon has not been elucidated. In study, we generated Sun5 knockout mice found head-to-tail linkage was broken in –/– mice, which similar to human syndrome. Furthermore, ultrastructural imaging revealed head-tail coupling apparatus (HTCA) centrosome were distant from nucleus...
Objective: To evaluate the value of cardiac troponin(cTn), myoglobin(Myo) combined with heart-type fatty acid-binding protein(H-FABP) detection in diagnosis early acute myocardial infarction(AMI).
 Methods: This study was a clinical comparative study. Eighty patients AMI hospitalized Tangshan Workers’ Hospital were selected as group, and another 80 individuals receiving normal physical examination control group from September 20, 2021 to 2022. The concentrations cTn, Myo H-FABPP,...
Our previous studies have shown that the inhibition of phosphatidylinositol 3-kinase (PI3K) or mTOR complex 1 can obviously promote Coxsackievirus B3 (CVB3)-induced apoptosis HeLa cells by regulating expression proapoptotic factors. To further illustrate it, Homo sapiens eIF4E-binding protein (4EBP1), p70S6 kinase (p70S6K), Akt1 and Akt2 were transfected to cells, respectively. And then, we established stable cell lines. Next, after CVB3 infection, in different groups was determined flow...
This work illustrated the mechanism contributing to process of Phosphatidylinostiol 3-kinase (PI3K)/protein kinase B (PKB)/mammalian target rapamycin (mTOR) signaling pathway, which has been demonstrated play an important role in virus-induced apoptosis, contributes Viral Myocarditis (VMC) pathogeneses. We examined expression Bax, Bim, caspase-3, caspase-9, and viral replication after Coxsackievirus B3 (CVB3) infection using mTOR inhibitor PI3K pretreated HeLa cells, respectively. Apoptosis...
Abstract Spermatogenesis is a complex process that includes spermatogonia self-renewal, spermatocyte meiosis and spermatozoa assembly. Recent studies have revealed WD40-repeat domain-containing (WDR) proteins play important roles in division, flagella assembly head shaping. In this study, we investigated the expression pattern of WDR87 found it was highly expressed testis both humans mice. Immunofluorescence staining mouse distributed perinuclear cytoplasm primary spermatocytes, secondary...
Lung cancer is the leading cause of death in patients. Based on a modular and comprehensive analysis method, it intended to identify their common pathogenesis. We downloaded data analyzed differences lung adenocarcinoma samples, squamous cell carcinoma normal samples. Co-expression analysis, enrichment hypergeometric testing were used predict transcription factors, ncRNAs, retrospective target genes. get 4596 differentially expressed genes high multiples clustered into 14 modules...
ObjectiveInvasive lung adenocarcinoma(ILA) with micropapillary (MPP)/solid (SOL) components has a poor prognosis. Preoperative identification is essential for decision-making subsequent treatment. This study aims to construct and evaluate super-resolution(SR) enhanced radiomics model designed predict the presence of MPP/SOL preoperatively provide more accurate individualized treatment planning.MethodsBetween March 2018 November 2023, patients who underwent curative intent ILA resection were...
Spermatogenesis is a complex process. Two spermatocytes expression sequence tags (ESTs) BG101130 and BG100990 were found. Their putative amino acid sequences have high homology with rat Spag4 (sperm antigen 4). By electrical hybridization, novel cDNA encoding polypeptide of 348 residues was identified from mouse testis library. The new gene designated as SRG4 (Spermatogenesis related 4) (GenBank accession No. AY307077). Results Northern blot RTPCR revealed that expressed specifically in...