A5101643553- Microtubule and mitosis dynamics
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Cancer Cells and Metastasis
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Cancer Genomics and Diagnostics
- RNA Research and Splicing
- Genomic variations and chromosomal abnormalities
- Cancer-related gene regulation
- CAR-T cell therapy research
- Colorectal Cancer Surgical Treatments
- RNA and protein synthesis mechanisms
- Hippo pathway signaling and YAP/TAZ
- Epigenetics and DNA Methylation
- Peptidase Inhibition and Analysis
- Immune cells in cancer
- Gastric Cancer Management and Outcomes
- CRISPR and Genetic Engineering
- Colorectal and Anal Carcinomas
Yan'an Hospital Affiliated To Kunming Medical University
2014-2021
Kunming Medical University
2014-2021
University of California, Berkeley
2000-2008
Background and Aims Hepatocellular carcinoma (HCC) is associated with high malignancy rates. Recently, a known deacetylase silent information regulator 1 (SIRT1) was discovered in HCC, its presence positively correlated metastasis. N 6 ‐methyladenosine (m A) the most prominent modification, but exact mechanisms on how SIRT1 regulates m A modification to induce hepatocarcinogenesis remain unclear. Approach Results Here we demonstrate that exerts an oncogenic role by down‐regulating fat mass...
Cytokine-induced killer (CIK) cells are an emerging approach of cancer treatment. Our previous study have shown that CIK stimulated with combination IL-2 and IL-15 displayed improved proliferation capacity tumor cytotoxicity. However, the mechanisms cell acquisition cytolytic function against induced by not been well elucidated yet. CIKIL-2 CIKIL-15 were generated from peripheral blood mononuclear primed IFN-γ, in OKT3 respectively. RNA-seq was performed to identify differentially expressed...
Previous studies have reported that m6a modification promotes tumor immune escape by affecting microenvironment (TME). Due to the complexity of TME, a single biomarker is insufficient describe complex biological characteristics and its microenvironment. Therefore, it more meaningful explore group effective biomarkers reflecting different cancer evaluate solid tumors. Here, gene CD34/CD276 with m6A peak was obtained sequencing (MeRIP-seq) colon (CRC)clinical samples combined MsIgDB database,...
Abstract Studies have proven that IL-2 and IL-15 showed contrasting roles during CIK cells preparation. By employing microarray, we analyzed miRNA expression profiles of PBMC, . Advanced bioinformatic analyses were performed to explore the key miRNAs which may regulate cell proliferation anti-tumor activity CIK. We identified 261 differentially expressed (DEMs) between PBMC 249 DEMs MiR-143-3p/miR-145-5p was cluster positively proliferation. In contrast, miR-340-5p/miR-340-3p negatively via...
Objective To analyse the clinical value of saving left colic artery in laparoscopic assisted anterior resection rectal cancer when processing inferior mesenteric artery. Methods The data 71 patients who underwent from Jan. 2014 to Jun. 2015 were retrospectively analysed, these divided into two groups based on LCA or not. The amount bleeding volume, operation time, number lymph nodes dissected , occurrence anastomotic leakage, recurrence and metastasis after 1 year,...