A5100644764- Traditional Chinese Medicine Analysis
- Traditional Chinese Medicine Studies
- Cardiac Ischemia and Reperfusion
- Ginseng Biological Effects and Applications
- Natural product bioactivities and synthesis
- Immune Cell Function and Interaction
- RNA modifications and cancer
- Pharmacological Effects of Natural Compounds
- Chromatography in Natural Products
- Immunotherapy and Immune Responses
- Food Quality and Safety Studies
- Cell death mechanisms and regulation
- Congenital heart defects research
- Cancer-related molecular mechanisms research
- Medicinal Plant Pharmacodynamics Research
- Vitamin C and Antioxidants Research
- Drug Transport and Resistance Mechanisms
- Natural Antidiabetic Agents Studies
- Tea Polyphenols and Effects
- Bioactive Compounds and Antitumor Agents
- Eicosanoids and Hypertension Pharmacology
- Bone Metabolism and Diseases
- Medicinal Plants and Bioactive Compounds
- Neuroinflammation and Neurodegeneration Mechanisms
- Inflammatory Bowel Disease
Northwest University
2019-2025
Qingdao Agricultural University
2019-2024
Tianma Microelectronics (China)
2024
Hebei Provincial Center for Disease Control and Prevention
2024
Chengdu Women's and Children's Central Hospital
2022
Yan'an Hospital Affiliated To Kunming Medical University
2012-2022
Kunming Medical University
2012-2022
Guilin University of Aerospace Technology
2021-2022
Nanjing Agricultural University
2022
Yunnan Center for Disease Control And Prevention
2018-2022
Background Traditional Chinese medicinal herbs Cortex Moutan and Radix Salviae Milthiorrhizaeare are prescribed together for their putative cardioprotective effects in clinical practice. However, the rationale of combined use remains unclear. The present study was designed to investigate paeonol danshensu (representative active ingredient Milthiorrhizae, respectively) on isoproterenol-induced myocardial infarction rats its underlying mechanisms. Methodology Paeonol (80 mg kg−1) (160 were...
Abstract Paeonol and danshensu is the representative active ingredient of traditional Chinese medicinal herbs Cortex Moutan Radix Salviae Milthiorrhizae, respectively. combination (PDSS) has putative cardioprotective effects in treating ischemic heart disease (IHD). However, evidence for protective effect scarce pharmacological mechanisms remain unclear. The present study was designed to investigate PDSS on isoproterenol (ISO)-induced myocardial infarction rats elucidate potential mechanism....
The traditional Chinese medicine bufalin, extracted from toad’s skin, has been demonstrated to exert anticancer activities in various kinds of human cancers. mechanisms action lie its capacity induce apoptosis, or termed type I programmed cell death (PCD). However, II PCD, autophagy, participates cancer proliferation, progression, and relapse, as well. Recent studies on autophagy seem be controversial because the dual roles survival death. In good agreement with previous studies, we found...
Parkinson's disease (PD) is the second most prevalent progressive neurodegenerative disease.Although several hypotheses have been proposed to explain pathogenesis of PD, apoptotic cell death and oxidative stress are mechanisms.Tetramethylpyrazine (TMP) a biological component that has extracted from Ligusticum wallichii Franchat (ChuanXiong), which exhibits anti-apoptotic antioxidant roles.In current study, we aimed investigate possible protective effect TMP against dopaminergic neuron injury...
Background: Patients with diabetic liver injury are in the dilemma of lowering glucose and protecting function. This study aimed to uncover protective effect mechanism 1-deoxynojirimycin (1-DNJ), an alpha-glucosidase inhibitor, against injury. Methods: The db/db mice were gavaged 25 mg/kg, 50 100 mg/kg 1-DNJ for 8 weeks. At end administration, serum isolated further detection. biochemical indices including TC, TG, LDL-C, AST, ALT, TBiL detected serum. livers analyzed H&E, oil red, Masson...
Genistein, a major phytoestrogen of soy, is considered potential drug for the prevention and treatment post-menopausal osteoporosis. Mounting evidence suggested positive correlation between genistein consumption bone health both in vivo vitro. Earlier studies have revealed that acted as natural estrogen analogue which activated receptor exerted anti-osteoporotic effect. However, it remains unclear whether PTH, most crucial hormone regulates mineral homeostasis, participates process...
The current study was to evaluate the anti-thrombotic effect of alpha-linolenic acid (ALA) which isolated and purified from Jiaomu in vivo. seeds were crushed subsequently subjected saponification, hydrolysis, gradient freezing, urea inclusion complexation silver nitrate obtain unsaturated fatty acids. chemical characteristics ALA validated by 1HNMR, 13CNMR mass spectrometry, then its mixture with linoleic (1:1) evaluated following experiments. through our newly established methods. can...
Taking the red clay from Guilin, China as object, this paper prepares samples with different initial water contents, extracts crack parameters images on under cyclic drying and wetting through image processing, analyzes laws of development. In addition, parallel were subject to shrinkage tests direct shear same wetting. Based test results, authors discussed deformaiton strength change for wetting, examined relationship between cracking, properties, detiroation clay. The results show that:...
Abstract: Liposomes constitute one of the most popular nanocarriers for improving delivery and efficacy agents in cancer patients. The purpose this study was to design evaluate immunoliposome co-delivery bufalin anti-CD40 induce synergetic therapeutic while eliminating systemic side effects. Bufalin liposomes (BFL) conjugated with antibody (anti-CD40-BFL) showed enhanced cytotoxicity compared alone. In a mouse B16 melanoma model, intravenous injection anti-CD40-BFL achieved smaller tumor...
Cytokine-induced killer (CIK) cells are an emerging approach of cancer treatment. Our previous study have shown that CIK stimulated with combination IL-2 and IL-15 displayed improved proliferation capacity tumor cytotoxicity. However, the mechanisms cell acquisition cytolytic function against induced by not been well elucidated yet. CIKIL-2 CIKIL-15 were generated from peripheral blood mononuclear primed IFN-γ, in OKT3 respectively. RNA-seq was performed to identify differentially expressed...
Generation of cytokine-induced killer (CIK) cells is an emerging approach in adoptive donor lymphocyte infusion for patients with a wide range tumors. However, our previous vitro studies have shown that the killing efficacy CIK against lung cancer was lower than other tumor cells, while underlying mechanisms are not clear. We explored feasibility to improve mediated cytotoxicity cancer. Interleukin (IL)-15 pleiotropic cytokine stimulates cytolytic activity and secretion NK which may enhance...