A5101471994- Nonlinear Partial Differential Equations
- Sperm and Testicular Function
- Liver physiology and pathology
- Liver Disease Diagnosis and Treatment
- Reproductive Biology and Fertility
- Medical Research and Treatments
- Advanced Mathematical Modeling in Engineering
- Zebrafish Biomedical Research Applications
- Thyroid Disorders and Treatments
- Birth, Development, and Health
- Winter Sports Injuries and Performance
- Drug-Induced Hepatotoxicity and Protection
- Numerical methods in engineering
- Traumatic Brain Injury and Neurovascular Disturbances
- Cerebral Palsy and Movement Disorders
- Male Reproductive Health Studies
- Phagocytosis and Immune Regulation
- Healthcare Systems and Technology
- Selenium in Biological Systems
- Poisoning and overdose treatments
- Hospital Admissions and Outcomes
- Phytochemistry and Bioactivity Studies
- Heterotopic Ossification and Related Conditions
- Educational Systems and Policies
- Medicinal Plants and Bioactive Compounds
Anhui Medical University
2024-2025
Ministry of Education of the People's Republic of China
2024-2025
Huashan Hospital
2024
Fudan University
2024
Nanchang University
2024
Zhejiang Medicine (China)
2024
Beijing Institute of Technology
2018-2023
SUNY Downstate Health Sciences University
2021-2022
Kunming Medical University
2022
Gannan Normal University
2021-2022
Abstract Mesenchymal stem cells (MSCs) may have potential applications in regenerative medicine for the treatment of chronic liver diseases (CLDs). Human menstrual blood is a novel source MSCs, termed blood-derived (MenSCs). Compared with bone marrow MenSCs exhibit higher proliferation rate and they can be obtained through simple, safe, painless procedure without ethical concerns. Although therapeutic efficacy has been explored some diseases, their effects on fibrosis are still unclear. In...
Parkinson's disease (PD) is the second most prevalent progressive neurodegenerative disease.Although several hypotheses have been proposed to explain pathogenesis of PD, apoptotic cell death and oxidative stress are mechanisms.Tetramethylpyrazine (TMP) a biological component that has extracted from Ligusticum wallichii Franchat (ChuanXiong), which exhibits anti-apoptotic antioxidant roles.In current study, we aimed investigate possible protective effect TMP against dopaminergic neuron injury...
Geraniin, a polyphenol isolated from Phyllanthus amarus, possesses extensive biological and pharmaceutical activities. In this study, we investigated the protective effect against cerebral ischemia/reperfusion (I/R) injury of geraniin explored its potential mechanism. Middle artery occlusion/reperfusion (MCAO/R) was used to simulate I/R in vivo, oxygen-glucose deprivation/reoxygenation (OGD/R) applied establish an vitro model injury. performed TTC HE staining adopted neurological score...
Abstract Liver fibrosis can cause hepatitis B virus (HBV)‐associated hepatocellular carcinoma. Menstrual blood‐derived mesenchymal stem cells (MenSCs) ameliorate liver through paracrine. Single‐cell RNA sequencing (scRNA‐seq) may be used to explore the roadmap of activated hepatic stellate cell (aHSC) inactivation target fibrosis. This study established HBV transgenic (HBV‐Tg) mouse model carbon tetrachloride (CCl 4 )‐induced and demonstrated that MenSCs migrated injured improve serological...
Background: Thyroid hormones (THs) are essential endocrine that play key roles in individual's growth and development. There is limited knowledge about the association between maternal TH concentrations variations with normal thyroid function during pregnancy offspring's glycolipid metabolism. Methods: A total of 1130 mother-child pairs from Ma'anshan birth cohort were included this prospective study. Maternal levels peroxidase antibodies measured 1st, 2nd, 3rd trimesters childhood follow-up...
Abstract In this paper, we establish a sharp concentration-compactness principle associated with the singular Adams inequality on second-order Sobolev spaces in <m:math xmlns:m="http://www.w3.org/1998/Math/MathML"> <m:msup> <m:mi>ℝ</m:mi> <m:mn>4</m:mn> </m:msup> </m:math> {\mathbb{R}^{4}} . We also give new compact embedding which states <m:mrow> <m:mi>W</m:mi> <m:mn>2</m:mn> <m:mo>,</m:mo> </m:mrow> <m:mo></m:mo> <m:mo stretchy="false">(</m:mo> stretchy="false">)</m:mo>...
Abstract Let <m:math xmlns:m="http://www.w3.org/1998/Math/MathML"> <m:mi>I</m:mi> </m:math> I be a bounded interval of <m:mi mathvariant="double-struck">R</m:mi> {\mathbb{R}} and <m:msub> <m:mrow> <m:mi>λ</m:mi> </m:mrow> <m:mn>1</m:mn> </m:msub> <m:mo>(</m:mo> <m:mo>)</m:mo> {\lambda }_{1}\left(I) denote the first eigenvalue nonlocal operator <m:msup> <m:mo stretchy="false">(</m:mo> <m:mo>−</m:mo> mathvariant="normal">Δ</m:mi> stretchy="false">)</m:mo> <m:mstyle displaystyle="false">...
Ticlopidine has inhibitory effects on platelet aggregation via ADP (adenosine diphosphate), release reaction and depolymerization. In clinical practice, it is commonly used to prevent heart, cerebrovascular other thromboembolic diseases. However, ticlopidine also been reported have teratogenic the though its specific molecular mechanism remains unclear. this study, zebrafish embryos were as model organisms examine toxicity effect of ticlopidine. Zebrafish exposed 6, 7.5, 9 mg/L solutions...
We conducted this study to analyze the sperm DNA fragmentation index, conventional semen parameters, blood microelements and seminal plasma reactive oxygen species (ROS) in patients with male infertility determine association between each of above physiological parameters index infertility. Eighty cases infertile males 20 normal children were divided into control groups, respectively. Sperm serum microelement content ROS levels detected, existing correlation various studied. The had no...
Sesamin (Ses) from Sesamun indicum seeds has potent antioxidants and anti-inflammatory effects.This study focused on the antioxidant effects of Ses Carbon tetrachloride (CCl4)-induced hepatic fibrosis in experimental rats potential mechanism underlying activation NF-kB pathway.Hepatic was induced by interaperitoneally (i.p.) administered with 20% CCl4 corn oil (2 mL/kg for 8 weeks) rats. After weeks, activities serum alanine aminotransferase (ALT), aspartate (AST), total bilirubin (TBIL)...
Abstract Objective To explore the association between maternal thyroid peroxidase antibody (TPOAb) exposure and 5- to 6-year-old children's cardiometabolic risk (CMR). Methods A total of 2129 mother–child pairs were recruited from Ma'anshan Birth Cohort (MABC) study. Serum TPOAb was retrospectively measured in pregnant women using an electrochemiluminescence immunoassay. CMR score evaluated by serum glycolipids, blood pressure, waist circumference for children aged 5-6 years. Growth mixture...
The aim of this paper is to investigate the effects ethyl pyruvate (EP) on experimental liver fibrosis induced by bile duct ligation (BDL) and explore underlying molecular mechanisms.Rats were randomly divided into three groups: sham group, BDL BDL+EP group. Liver was common evaluated serum biochemical parameter levels, Masson's trichrome staining, α-SMA expression, collagen I deposition. levels Nrf2 signaling pathway-related antioxidant genes (Nrf2, SOD2, NQO1, GSH-Px) in tissues also...
Abstract The nuclear receptor Nur77 plays paradoxical roles in numerous cancers. However, whether inhibits esophageal squamous cell carcinoma (ESCC) growth and affects immunological responses against ESCC has not been determined. functional role of was investigated this study using human lines, quantitative real-time polymerase chain reaction (PCR), proliferation colony formation assays, flow cytometry analysis, western blotting animal models. target gene controlled by verified...
Abstract In this paper, we develop an extremely simple method to establish the sharpened Adams-type inequalities on higher-order Sobolev spaces $W^{m,\frac {n}{m}}(\mathbb {R}^n)$ in entire space $\mathbb {R}^n$ , which can be stated as follows: Given $\Phi \left ( t\right ) =e^{t}-\underset {j=0}{\overset {n-2}{\sum }} \frac {t^{j}}{j!}$ and Adams sharp constant $\beta _{n,m}$ . Then, $$...
Though much work has been done with respect to the existence of extremals critical first order Trudinger-Moser inequalities in $W^{1,n}(\mathbb{R}^n)$ and higher Adams on finite domain $Ω\subset \mathbb{R}^n$, whether there exists an extremal function for entire space $\mathbb{R}^n$ still remains open. The current paper represents attempt this direction. classical blow-up procedure cannot apply solving type inequality because absence Pólya-Szegö\ inequality. In paper, we develop some new...
The 80-hour per week work limit resulted in an increased number of patient handoffs. A satisfactory handoff system should optimize the exchange vital information while concisely minimizing error. This project describes our experience and lessons learned successfully developing implementing Electronic Health Record (EHR)-integrated based on I-PASS model. system, termed Physician Handoff, was refined through end-user feedback. End-users were evaluated quality following categories: Illness...
Let $F$ be convex and homogeneous of degree $1$, its polar $F^{o}$ represent a finsler metric on $\mathbb{R}^{n}$, $\Omega$ any bounded open set in $\mathbb{R}^{n}$. In this paper, we first construct the theoretical structure anisotropic harmonic transplantation. Using transplantation, co-area formula, limiting Sobolev approximation method, delicate estimate level Green function, investigate optimal concentration Trudinger-Moser functional \[ \int_{\Omega}e^{\lambda_{n}|u|^{\frac{n}{n-1}}}dx...