A5100735935- Air Quality and Health Impacts
- Liver Disease Diagnosis and Treatment
- Acute Myocardial Infarction Research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Climate Change and Health Impacts
- Gout, Hyperuricemia, Uric Acid
- Pharmacological Effects and Toxicity Studies
- Chronic Kidney Disease and Diabetes
- Renal Transplantation Outcomes and Treatments
- Cardiac Imaging and Diagnostics
- Inflammasome and immune disorders
- Alcohol Consumption and Health Effects
- Blood Pressure and Hypertension Studies
- Pharmacogenetics and Drug Metabolism
- Drug Transport and Resistance Mechanisms
- Air Quality Monitoring and Forecasting
- Estrogen and related hormone effects
- Angiogenesis and VEGF in Cancer
- Receptor Mechanisms and Signaling
- Cardiovascular Health and Disease Prevention
- Gastric Cancer Management and Outcomes
- Cardiovascular Function and Risk Factors
- Heavy Metal Exposure and Toxicity
- Noise Effects and Management
- Protease and Inhibitor Mechanisms
Third Xiangya Hospital
2016-2025
Central South University
2016-2025
Hangzhou First People's Hospital
2023
Hunan Cancer Hospital
2015-2017
Xiangya Hospital Central South University
2011-2014
Hypertension Institute
2014
Kao Yuan University
2014
Sun Yat-sen University
2013
University of Pittsburgh
2013
Hanyang University
2013
Vascular precursor cells with angiogenic potentials are important for tissue repair, which is impaired in diabetes mellitus. MicroRNAs recently discovered key regulators of gene expression, but their role vascular cell-mediated angiogenesis mellitus unknown. We tested the hypothesis that microRNA miR-27b rescues bone marrow-derived cell (BMAC) function vitro and vivo type 2 diabetic mice.BMACs from adult male db/db normal littermate db/+ mice were used. expression was decreased BMACs. mimic...
Non-alcoholic fatty liver disease (NAFLD), recognized as the manifestation of metabolic syndrome, is highly prevalent in general population. Recent studies suggest that lipid accumulation product significantly associated with abnormalities. The aim this study was to assess accuracy (LAP) an effective screening tool for diagnosing NAFLD population.A total 40,459 subjects aged ≥18 years were enrolled cross-sectional study. LAP calculated [waist circumference (cm) - 65] × triglyceride...
Growing evidences support that androgen displays beneficial effects on cardiovascular functions although the mechanism of actions remains to be elucidated. Modulation endothelial cell growth and function is a potential actions. We demonstrated in present study androgens [dihydrotestosterone (DHT) testosterone], but not 17β-estradiol, produced time- dose-dependent induction proliferation primary human aortic cells (HAECs) as evident by increases viable number DNA biosynthesis. Real-time...
Increasing evidence has linked ambient fine particulate matter (ie, no larger than 2.5 μm [PM2.5]) to chronic kidney disease (CKD), but their association not been fully elucidated, especially in regions with high levels of PM2.5 pollution. This study aimed investigate the long-term exposure incident CKD mainland China.Prospective cohort study.72,425 participants (age ≥18 years) without were recruited from 121 counties Hunan Province, China.Annual mean concentration at residence each...
It is widely accepted that metabolic syndrome associated with an increased risk of chronic kidney disease (CKD). To investigate whether coexisting a necessary condition for CKD in overweight and obese.A cohort study 6852 Chinese individuals from August 2007 to December 2012. Examinations included questionnaire, physical measurements, blood sampling. Hazard ratios incident were estimated according combinations BMI category absence or presence syndrome.For CKD, multivariable adjusted hazard...
Objective— Circulating angiogenic cells play an essential role in angiogenesis but are dysfunctional diabetes mellitus characterized by excessive oxidative stress. We hypothesize that stress–mediated upregulation of thrombospondin-2 (TSP-2), a potent antiangiogenic protein, contributes to diabetic bone marrow–derived cell (BMAC) dysfunction. Approach and Results— BMACs were isolated from adult male type 2 db/db mice control db/+ (C57BLKS/J) mice. In Matrigel tube formation assay, function...
The aim of this study was to assess the correlation between blood lead levels and both serum uric acid hyperuricemia in adult residents living within an area China with pollution. We conducted a cross-sectional analysis 2120 subjects (1180 whom were male) ages 20 75 years who had undergone health examinations at Centers for Disease Control Prevention (CDC) lead-polluted June 2013 September 2014. Blood positively correlated males (r = 0.095, p 0.001) females 0.134, < 0.001). Multivariate...
The development of hypertension involves extensive arterial wall remodeling, in which cysteine proteases play an essential role. Cathepsin L/V has been reported to be a protease that is closely intertwined with the tissue inflammatory response and extracellular matrix accumulation, allowing it regulate remodeling. aim this study was determine role cathepsin its regulatory pathway vascular remodeling hypertension. We showed endogenous inhibitor cystatin C, as well mitogen-activated protein...
Vitexins, isolated from the seeds of Chinese herb Vitex negundo, is known to exert antitumor activity in cancer xenograft models and cell lines. The aim current study was examine whether Akt/forkhead box protein O3a (FOXO3a) pathway mediates biological effects purified vitexin compound 1 (VB-1) hepatocellular carcinoma (HCC) cells. effect VB-1 on viability HCC lines HepG2, Hep3B, Huh-7 human embryonic liver cells L-02 investigated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium...
Evidence indicates a role for dyslipidemia in the development of chronic kidney disease (CKD). However, association lipid abnormalities and their ratios with using new CKD Epidemiology Collaboration (CKD-EPI) equation is not well understood.This cross-sectional study included 48,054 adult subjects. was defined as an estimated glomerular filtration rate <60 ml/min/1.73 m2 or dipstick-positive proteinuria. Logistic regression models were used to examine relationship between variables CKD.The...
In the past 10 years, several publications have highlighted role of regulator G protein signalling (RGS) family in multiple diseases, including cardiovascular diseases. As one multifunctional members, RGS14 is involved various biological processes, such as synaptic plasticity, cell division, and phagocytosis. However, diseases remains unclear. present study, we used a genetic approach to examine pathological cardiac remodelling vivo vitro. We observed that was down-regulated human failing...