A5083506223- Pain Mechanisms and Treatments
- Anesthesia and Pain Management
- Stress Responses and Cortisol
- Nerve injury and regeneration
- Neuroinflammation and Neurodegeneration Mechanisms
- Anesthesia and Sedative Agents
- Neuropeptides and Animal Physiology
- Neuroendocrine regulation and behavior
- Spine and Intervertebral Disc Pathology
- Bone health and osteoporosis research
- Intensive Care Unit Cognitive Disorders
- Pain Management and Opioid Use
- Neurogenesis and neuroplasticity mechanisms
- Tryptophan and brain disorders
- Aortic Disease and Treatment Approaches
- Bone Metabolism and Diseases
- Cardiac, Anesthesia and Surgical Outcomes
- Nerve Injury and Rehabilitation
- Bone health and treatments
- Anesthesia and Neurotoxicity Research
- Aortic aneurysm repair treatments
- Neuroscience of respiration and sleep
- Cardiac and Coronary Surgery Techniques
- Hemodynamic Monitoring and Therapy
- Neurotransmitter Receptor Influence on Behavior
Central South University
2015-2025
Second Xiangya Hospital of Central South University
2014-2025
Yunnan University
2015
Tsinghua University
2007
Institute of Molecular and Cell Biology
2006
Xiangya Hospital Central South University
2006
Fu Wai Hospital
1997-1998
Chinese Academy of Medical Sciences & Peking Union Medical College
1993-1998
Academia Sinica
1978
Institute of Cell Biology
1978
Abstract The precursor of brain derived neurotrophic factor (proBDNF), the unprocessed BDNF gene product, binds to its receptors and exerts opposing biologic functions mature BDNF. proBDNF is expressed in peripheral tissues but remain elusive. Here we showed that predominant receptor, p75 pan-neurotrophin receptor were upregulated nerve fibers inflammatory cells local tissue pain. Neutralization by polyclonal antibody attenuated pain different models Unilateral intra-plantar supplementation...
Abstract Background Sepsis-associated encephalopathy (SAE) increases the mortality of septic patients, but its mechanism remains unclear. The present study aimed to investigate roles T lymphocytes, proBDNF, and their interaction in pathogenesis SAE. Methods Fear conditioning tests were conducted for cognitive assessment lipopolysaccharide (LPS, 5 mg kg −1 )-induced mice. Meninges peripheral blood harvested flow cytometry or qPCR. FTY720 monoclonal anti-proBDNF antibody (McAb-proB) used...
Background: The pathogenic role of brain derived neurotrophic factor (BDNF) in the incisional pain is poorly understood. present study explores BDNF incision-induced hypersensitivity. Methods: A longitudinal incision was made one plantar hind paw isoflurane-anesthetized rats. Dorsal root ganglias (DRG) and spinal cords were removed at various postoperative times (1–72 h). Expression pattern determined by immunohistochemistry double-labeling immunofluorescence. Lidocaine-induced blockade...
Depression and anxiety are two affective disorders that greatly threaten the mental health of a large population worldwide. Previous studies have shown brain-derived neurotrophic factor precursor (proBDNF) is involved in development depression. However, it still elusive whether proBDNF anxiety, if so, which brain regions regulate these disorders. The present study aims to investigate role hippocampus depression anxiety. Rat models an anxiety-like phenotype depression-like were established by...
Inappropriate expansion of antibody-secreting cells (ASCs) is typical systemic lupus erythematosus (SLE), but the regulatory signaling pathogenic ASCs unclear. The present study shows that brain-derived neurotrophic factor precursor (proBDNF) and its high-affinity pan-75 neurotrophin receptor (p75NTR) are highly expressed in CD19+CD27hiCD38hi patients with SLE CD19+CD44hiCD138+ lupus-like mice. increased proBDNF+ were positively correlated clinical symptoms higher titers autoantibodies SLE....
<title>Abstract</title> Background Despite surgery is the recommended treatment for oral cancer patients, little known about intraoperative blood loss in this population. This study sought to identify risk factors haemorrhage resection and free flap reconstruction surgery, develop a machine learning-based predictive model. Methods retrospective cohort included patients with who underwent fibular at tertiary hospital. Demographic clinical parameters were selected using Recursive Feature...
Postoperative fever (POF) is a common occurrence in patients undergoing major surgery, presenting challenges and burdens for both surgeons yet. This study endeavors to examine the incidence, identify risk factors, establish machine learning-based predictive model POF following surgery of oral cancer. A total seven hundred twenty-seven consecutive radical resection cancer were retrospectively investigated. The analysis encompassed 34 parameters, incorporating demographic clinical...
<title>Abstract</title> Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are severe conditions with high morbidity mortality, effective treatments limited. Neuroimmune interactions play a critical role in homeostasis, but it remains unclear if specific brain regions regulate inflammation. Here, we unveil the of neuroimmune signaling ALI, focusing on regulatory function corticotropin-releasing hormone (CRH) neurons paraventricular nucleus (PVN) hypothalamus. Using viral...
Monitoring the left atrial pressures (LAP) is an important perioperative management tool for maintaining adequate cardiac output. However, incorrect placement of LAP-monitoring catheter tip often leads to inherent risk. This study aimed evaluate length LAP in pediatric open-heart surgery and devise a simple formula predict ideal insertion based on correlated demographic clinical characteristics. We conducted retrospective cohort involving 79 infant patients aged ≤ 1 year who underwent right...
A recent study has demonstrated that surgical incision induces an anxiety-like behavior but its relationship with incision-evoked mechanical hypersensitivity remains elusive. Extracellular signal-regulated kinase (ERK) activity in the anterior cingulate cortex (ACC) is important for affective pain. The current aims to explore ERK1/2 ACC and role development of anxiety after incision.Anxiety-like was measured by elevated plus maze experiment open field test hind paw incision. phosphorylation...
Neuropathic pain evoked by nerve injury is frequently accompanied deterioration of emotional behaviors, but the underlying signaling mechanisms remain elusive. Glutamate (Glu) major mediator excitatory synaptic transmission throughout brain, and abnormal activity glutamatergic system has been implicated in pathophysiology associated comorbidities. In this study we used partial sciatic ligation (PSNL) model neuropathic rats to characterize development anxiety-like behavior, expression...
Rationale: Brain-derived neurotrophic factor precursor (proBDNF) is expressed in the central nervous system (CNS) and immune system.However, role of proBDNF pathogenesis multiple sclerosis (MS) unknown.Methods: Peripheral blood post-mortem brain spinal cord specimens were obtained from patients to analyze expression peripheral lymphocytes infiltrating cells lesion site.The profile was also examined experimental autoimmune encephalomyelitis (EAE) mouse model, polyclonal monoclonal...
Sepsis-associated encephalopathy (SAE) is a risk factor for cognitive and memory dysfunction; however, the mechanism remains unclear. Brain-derived neurotrophic (BDNF) was reported to have positive effect on cognition emotion regulation, but study of its precursor, proBDNF, has been limited. This aimed elucidate effects associated mechanisms hippocampal proBDNF in lipopolysaccharide (LPS)-induced SAE mouse model. In this study, we found that mice exhibited dysfunction day 7 after LPS...
Patients suffering from sepsis-induced acute lung injury (ALI) exhibit a high mortality rate, and their prognosis is closely associated with infiltration of neutrophils into the lungs. In this study, we found significant elevation CD64
Objectives. The incidence of fentanyl-induced cough (FIC) during induction general anesthesia varies around 40% and is undesirable. It increases intracranial, intraocular, intra-abdominal pressures. This prospective, randomized, double-blind, placebo-controlled study evaluated the effect dexmedetomidine (DEX) pretreatment on severity FIC. Methods. Altogether 300 patients undergoing elective surgical procedures were randomly allocated into three groups (I, II, III; n = 100) administered...
Brain-derived neurotrophic factor precursor (proBDNF) has been reported to strengthen the dysfunction of monocytes/macrophages in animal studies. However, it is still unknown roles proBDNF monocytes inflammatory diseases humans. In present study, we showed that and pan receptor p75 were significantly upregulated from healthy donors (HD) after lipopolysaccharide treatment. Exogenous treatment CD40 proinflammatory cytokines expression including interleukin (IL)-1β, IL-6, tumor necrosis...
Bone mineral density (BMD) and microstructural variations have been extensively investigated in recent years; however, the compensation for bone loss between different regions is still unclear.To fully characterize regional as well microstructure dynamic changes of rat tibial trabeculae that occur with associated estrogen deficiency.Female Sprague-Dawley rats were ovariectomized (OVX), sham-operated (sham), or left unoperated (baseline control). The tibiae harvested at baseline,...
The role of affective dimension in the postoperative pain is still poorly understood. present study investigated development anxiety-like behavior and amygdala sensitization incisional pain. Using hind-paw incision model rats, we showed that surgical induced as determined by elevated plus-maze open-field tests. Intraperitoneal (IP) morphine administration reversed mechanical allodynia a dose-dependent manner. Gabapentin also partially reduced incision-evoked After incision, expression...