A5101823096- Animal Virus Infections Studies
- Virus-based gene therapy research
- Viral gastroenteritis research and epidemiology
- Salmonella and Campylobacter epidemiology
- Viral Infections and Immunology Research
- Migraine and Headache Studies
- Listeria monocytogenes in Food Safety
- Vibrio bacteria research studies
- Animal Disease Management and Epidemiology
- Cancer-related molecular mechanisms research
- Microbial Metabolism and Applications
- Antibiotic Resistance in Bacteria
- Bipolar Disorder and Treatment
- Tryptophan and brain disorders
- Reproductive System and Pregnancy
- Neurological Disorders and Treatments
- Cancer Immunotherapy and Biomarkers
- Cancer, Stress, Anesthesia, and Immune Response
- Identification and Quantification in Food
- Cerebrovascular and Carotid Artery Diseases
- Parasitic Infections and Diagnostics
- Olfactory and Sensory Function Studies
- Legionella and Acanthamoeba research
- Cancer, Lipids, and Metabolism
- Immune cells in cancer
South China Agricultural University
2017-2025
Second Xiangya Hospital of Central South University
2024-2025
Central South University
2024-2025
Zhejiang Industry Polytechnic College
2025
Second Affiliated Hospital of Zhejiang University
2020-2024
Chinese PLA General Hospital
2019-2024
University of Amsterdam
2024
Sichuan Agricultural University
2024
Key Laboratory of Guangdong Province
2022-2023
HKUST Shenzhen Research Institute
2023
Background Neutrophils-linked premetastatic niche plays a key role in tumor metastasis, but not much is known about the heterogeneity and diverse of neutrophils formation. Our study focuses on existence biological function rarely delved subset neutrophils, named as tumor-associated aged (Naged, CXCR4 + CD62L low ), involved formation during breast cancer metastasis. Methods We explored distributions Naged 206 patients mice models (4T1 MMTV-PyMT) by flow cytometry. The ability to form...
Porcine circovirus type 2 (PCV2) is a significant pathogen responsible for porcine circovirus-associated diseases (PCVAD), and it widely prevalent in pig farms, leading to huge economic losses the industry. Currently, ability of PCV2 enhance its own replication by using antiviral inflammatory factors IFNα, IFNβ, IL-2 complex immune escape mechanism remain unclear, which has attracted wide attention. Research indicated that GTPase-activating protein (SH3 domain)-binding 1 (G3BP1) involved...
Abstract Background Energy metabolism disorders and neurogenic inflammation play important roles in the central sensitization to chronic migraine (CM). AMP-activated protein kinase (AMPK) is an intracellular energy sensor, its activation regulates reduces neuropathic pain. However, studies on involvement of AMPK regulation CM are currently lacking. Therefore, this study aimed explore mechanism underlying CM. Methods Mice with recurrent nitroglycerin (NTG)-induced were used detect expression...
Chronic stress promotes most hallmarks of cancer through impacting the malignant tissues, their microenvironment, immunity, lymphatic flow, etc. Existing studies mainly focused on roles stress-induced activation systemic sympathetic nervous system and other hormones, organ specificity chronic in shaping pre-metastatic niche remains largely unknown. This study investigated role remodeling lung breast cancer.Breast mouse models with were constructed by restraint or unpredictable stress....
China’s shale gas has undergone nearly 20 years of exploration; unconventional oil and geological evaluation theories research methods have been greatly enriched, but how to quickly, conveniently, accurately identify the sweet spots is still puzzling many researchers. This study focuses on black Wufeng–Longmaxi Formation in southeastern edge Sichuan Basin; lithofacies classification, relationship between depositional environments, correlation gas–bearing capacity are discussed. At last, we...
ABSTRACT Background The resting‐state functional connectivity (FC) patterns of the fronto‐parietal network (FPN) and language (LN) underlying bipolar disorder (BD) are obscure. This study aimed to uncover abnormal FC FPN LN BD their evolution following treatment. Methods Imaging data at rest state clinical variables were acquired from 82 patients with (with 43 finishing follow‐up) 88 healthy controls (HCs). Seed‐based analysis was performed, correlations between FCs investigated whole‐brain...
Astrocytic activation might play a significant role in the central sensitization of chronic migraine (CM). However, temporal characteristics astrocytic trigeminal nucleus caudalis (TNC) and molecular mechanism under process remain not fully understood. Therefore, this study aims to investigate duration levels change explore correlation between cytokines release.We used mice model induced by recurrent dural infusion inflammatory soup (IS). The variation with time IS-induced mechanical...
African swine fever (ASF), caused by ASF virus (ASFV), is a highly contagious and lethal disease of domestic pigs leading to tremendous economic losses. As there are no vaccines drugs available. An effective diagnosis eliminate ASFV-infected crucial strategy prevent control ASF. To this end, ASFV capsid protein p72 was expressed using Chinese hamster ovary (CHO) cells subsequently conjugated with horseradish peroxidase (HRP) develop one-step double-antigen sandwich enzyme-linked...
Recently, a novel atypical porcine pestivirus (APPV) in pig was reported. In this study, two APPV strains, APPV-China/GZ01/2016 (GZ01) and APPV-China/GD-SD/2016 (GD-SD), were identified newborn piglet herds with congenital tremor from China. The open reading frame of the strains shared an 83.5% nucleotide identity. Phylogenetically, placed into groups: GZ01 belonged to group I GD-SD II. A high viral load detected cerebellum (quantification cycles ＜ 26). Further studies should be carried out...
Campylobacter is a zoonotic pathogen that causes foodborne diarrheal illness globally. To better understand health risks in Southeastern China, spp. were surveyed humans and representative poultry products over three years. Representative 195 isolates (n=148, jejuni; n=45, coli; n=2 hyointestinalis) examined for genetic relatedness antimicrobial susceptibility. Nearly all (99.0%, 193/195) resistant to at least one class of antimicrobials, 45.6% (89/195) the exhibited multi-drug resistant....
Drugs that target immune checkpoint have become the most popular weapon in cancer immunotherapy, yet only practical benefits for a small percentage of patients. Tumor cells constantly interact with their microenvironment, which is made up variety as well endothelial and fibroblasts. Immune expression blocked signaling tumor microenvironment (TME) are key to progression. In this study, we perform deliberation convolution on TCGA database human lung, breast, colorectal infer crosstalk between...
The circular replication-associated protein (Rep)-encoding single-stranded (CRESS) DNA virus emergence in diverse host has been associated with severe disease. Porcine circovirus-like (Po-Circo-like [PCL] virus) is a CRESS virus, the prevalence and pathogenicity of which are rarely studied.We obtained two blood samples, four faecal intestinal samples from pig farm suffered diarrheal disease delivery room September 2020 attempted to isolate identify causative pathogen. Subsequently, only PCL...
Porcine reproductive and respiratory syndrome (PRRS) is a vertically transmitted disorder that typically characterized by miscarriage, premature birth, stillbirth in pregnant sows after infection. Such characteristics indicate PRRSV can infect penetrate the porcine placental barrier to fetus piglets. The trophoblast an important component of barrier, secretes various hormones, including estrogen progesterone, maintain normal pregnancy embryonic development during pregnancy. It conceivable...
Porcine reproductive and respiratory syndrome (PRRS) has leaded to an enormous loss per year the swine industry, its etiology porcine virus (PRRSV) is a highly mutated in pigs. To fully understand genetic characteristics of PRRSV genome South China, this study collected lung samples infected with Guangdong Hainan province from 2014 2015 tried isolate PRRSV. Finally, complete genomes isolated strains were sequenced analyzed.Virus isolation was performed MARC-145 cells. The 13 fragments...
Increasing human salmonellosis caused by Salmonella enterica serovar Kentucky and London has raised serious concerns. To better understand possible health risks, insights were provided into specific genetic traits antimicrobial resistance of 88 representative isolates from food sources in Zhejiang Province, China, during 2016-2021. Phylogenomic analysis revealed consistent clustering the respective or sequence types, identified plausible interhost transmission via distinct routes. Each...