A5071816854- Glycosylation and Glycoproteins Research
- MicroRNA in disease regulation
- Animal Genetics and Reproduction
- Cancer-related molecular mechanisms research
- Genetic and phenotypic traits in livestock
- Infant Nutrition and Health
- Renal and related cancers
- Cell Adhesion Molecules Research
- Adhesion, Friction, and Surface Interactions
- Antimicrobial Peptides and Activities
- Immune Response and Inflammation
- NF-κB Signaling Pathways
- Monoclonal and Polyclonal Antibodies Research
- Galectins and Cancer Biology
- Ziziphus Jujuba Studies and Applications
- Toxin Mechanisms and Immunotoxins
- Cancer Research and Treatments
- Force Microscopy Techniques and Applications
- Cellular Mechanics and Interactions
- Chemical Synthesis and Analysis
- Milk Quality and Mastitis in Dairy Cows
- Invertebrate Immune Response Mechanisms
- Heat shock proteins research
- Hepatitis B Virus Studies
- Inflammatory mediators and NSAID effects
Beijing Children’s Hospital
2018-2025
Capital Medical University
2015-2025
Zhejiang Industry Polytechnic College
2025
Guangdong Ocean University
2019-2024
Qingdao University
2015-2024
Maternal and Child Health Hospital of Sichuan Province
2022-2024
Jilin University
2012-2024
Hebei Agricultural University
2016-2022
Chengdu University of Technology
2021
Jilin Medical University
2020
Abstract Based on the known partial cDNA sequence of dragline silk protein an artificial gene monomer, a 360 bp sequence, was designed and polymerized to encode analog protein. Six tandem copies monomer were cloned into pBC1 vector microinjected pronuclei fertilized Kunming White eggs. Transgenic mice screened by Polymerase Chain Reaction (PCR) Southern blot which revealed that 10 (5 male, 5 female) among 58 transgenic positive. Milk five F0 eight F1 analyzed Western blot, two seven...
Arctigenin is a dibenzylbutyrolactone lignan isolated from Bardanae fructus, Arctium lappa L, Saussureamedusa, Torreya nucifera, and Ipomea cairica. It has been reported to exhibit anti-inflammatory activities, which mainly mediated through its inhibitory effect on nuclear transcription factor-kappaB (NF-κB). But the role of arctigenin in JAK-STAT3 signaling pathways still unclear. In present study, we investigated signal transducer activator 3 (STAT3) pathway evaluated whether suppression...
Background Abnormal activity of STAT3 is associated with a number human malignancies. Hsp90 plays central role in stabilizing newly synthesized proteins and participates maintaining the functional competency signaling transducers involved cell growth, survival oncogenesis, such as STAT3. interacts stabilizes Tyr-phosphorylated It has been reported that luteolin possesses anticancer through degradation Tyr705-phosphorylated Methodology/Principal Findings We found overexpression inhibited...
China’s shale gas has undergone nearly 20 years of exploration; unconventional oil and geological evaluation theories research methods have been greatly enriched, but how to quickly, conveniently, accurately identify the sweet spots is still puzzling many researchers. This study focuses on black Wufeng–Longmaxi Formation in southeastern edge Sichuan Basin; lithofacies classification, relationship between depositional environments, correlation gas–bearing capacity are discussed. At last, we...
Kawasaki Disease Shock Syndrome (KDSS) represents a severe manifestation of (KD). In recent years, logistic regression prediction models have gained widespread application in forecasting the occurrence probabilities various diseases. The objective this study is to explore clinical characteristics pediatric patients with KDSS complicated by coronary artery lesions (CALs) and develop validate model for predicting likelihood CALs children KDSS. Our enrolled 102 diagnosed at Cardiology...
Bovine mastitis is an inflammatory condition of the mammary gland often caused by (Staphylococcus aureus) S. aureus infection. The aim this study was to identify mastitis-related miRNAs and their downstream target genes, therefore elucidate regulatory mechanisms involved in disease progression resistance. Three healthy three mastitic cows were identified on basis somatic cell count bacterial culture milk, histological examination udder tissues. High-throughput RNA sequencing bioinformatic...
A sensitive competitive indirect enzyme-linked immunoassay (ciELISA) based on a rabbit monoclonal antibody (RabMAb) against chloramphenicol (CAP) has been developed and validated in this study. After optimisation of several key physicochemical factors, such as Tween-20 percentage, pH value ionic strength, the showed excellent performance within linear range 0.18–6.37 ng mL−1, with 50% inhibition concentration (IC50) 1.06 mL−1 limit detection (LOD) 0.1 mL−1. In addition, cross-reactivities...
Abstract High mobility group box 1 (HMGB1), a chromatin-binding nuclear protein, plays critical role in sepsis by acting as key “late-phase” inflammatory mediator. Integrin CD11b is essential for cell activation and migration, thus mediating responses. However, it unclear whether participates the development of sepsis. In this study, we report that contributes to LPS-induced endotoxin shock microbial sepsis, antagonism with blocking Ab or inhibitor Gu-4 protects mice against LPS-...
This study aimed to explore mechanisms of the effects hydroxysafflor yellow A (HSYA) on neural stem cells (NSCs) after heat stress (HS). Rat NSCs were cultured at 42 °C impose stress. Cell counting kit-8 and Edu assay used analyze NSC proliferation. Annexin V/PI apoptosis kit was detect apoptosis. Expression phosphorylation autophagy apoptosis-associated proteins determined by western blotting. We showed that HSYA significantly promoted proliferation attenuated also increased Bcl-2...
Endothelial PAS domain protein 1 (EPAS1) is a hypoxia-inducible that contributes to tumor progression. Hypoxia involved in aggressiveness and resistance chemotherapy ionizing radiation. In this study, we aimed assess the effects of EPAS1 silencing using polyethylenimine-poly(lactide-coglycolide) (PLGA)/poloxamer nanoparticles loaded with siRNA on BxPC-3 pancreatic cancer cells mouse model ectopic cancer. PLGA/poloxamer or scramble were prepared emulsion/solvent evaporation method. cultured...
Background High mobility group box 1(HMGB1) was first recognized as a nuclear protein that increased the chromatin remodeling and regulates transcription of many genes. In recent years, HMGB1 has been identified critical "late" pro-inflammatory mediator due to its unique secretion pattern lethal effects in sepsis. Therefore, preventing active release inhibiting activity become promising strategies for treatment Here, we reported therapeutic Gu-4, lactosyl derivative, on sepsis underlying...
The aim of this research was to explore the effects dietary substitution alfalfa hay by amaranth on production performance, rumen fermentation, nutrient digestibility, serum biochemical parameters and antioxidant ability in dairy cows.