A5101537458- Plant Molecular Biology Research
- Cancer therapeutics and mechanisms
- Plant Stress Responses and Tolerance
- Photosynthetic Processes and Mechanisms
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Lung Cancer Research Studies
- RNA Research and Splicing
- RNA modifications and cancer
- Neuroscience and Neuropharmacology Research
- Stress Responses and Cortisol
- Hormonal and reproductive studies
- Ginseng Biological Effects and Applications
- Neuroblastoma Research and Treatments
- Molecular Biology Techniques and Applications
- RNA Interference and Gene Delivery
- Plant and Fungal Interactions Research
- Biopolymer Synthesis and Applications
- Genomics and Phylogenetic Studies
- Virus-based gene therapy research
- Retinoids in leukemia and cellular processes
- Milk Quality and Mastitis in Dairy Cows
- bioluminescence and chemiluminescence research
- Plant biochemistry and biosynthesis
Yangtze University
2024
Beijing Forestry University
2015-2023
University of Hong Kong
2020
Qingdao National Laboratory for Marine Science and Technology
2020
Dalian Ocean University
2020
Heilongjiang Bayi Agricultural University
2019-2020
Hebei Medical University
2009-2019
Objective: The transcription factor forkhead box protein O1 (FOXO1) is critical for regulating cytokine and chemokine secretion. However, its function in the tumor microenvironment (TME) remains largely unexplored. In this study, we characterized prognostic value of FOXO1 interaction between tumor-derived M2 macrophages esophageal squamous cell carcinoma (ESCC). Methods: expression macrophage infiltration clinical samples mouse models were quantified using quantitative real-time polymerase...
Gibberellic acid-stimulated Arabidopsis (GASA) proteins, as cysteine-rich peptides (CRPs), play roles in development and reproduction biotic abiotic stresses. Although the GASA gene family has been identified plants, knowledge about GASAs Populus euphratica, woody model plant for studying stress, remains limited. Here, we referenced well-sequenced trichocarpa genome, whole genome of P. euphratica trichocarpa. 21 candidate genes 19 were categorized into three subfamilies by phylogenetic...
The current study focused on how dihydrotestosterone (DHT) regulates synaptic plasticity in the hippocampus of mild cognitive impairment male senescence-accelerated mouse prone 8 (SAMP8) mice. Five‑month‑old SAMP8 mice were divided into control, castrated and castrated-DHT groups, which treated with physiological doses DHT for a period 2 months. To determine regulatory mechanisms capacity, effects morphology synapse expression marker proteins investigated using immunohistochemistry, qPCR...
DNA methylation, one of the best-studied types chromatin modification, suppresses expression transposable elements, pseudogenes, repetitive sequences, and individual genes. However, extent variation genome-wide methylation in natural populations plants remain relatively unknown. To investigate whether this associates with important plant traits, including leaf shape photosynthesis, 20 413 sites were examined a poplar association population (505 individuals) using methylation-sensitive...
Bovine mastitis is an inflammatory condition of the mammary gland often caused by (Staphylococcus aureus) S. aureus infection. The aim this study was to identify mastitis-related miRNAs and their downstream target genes, therefore elucidate regulatory mechanisms involved in disease progression resistance. Three healthy three mastitic cows were identified on basis somatic cell count bacterial culture milk, histological examination udder tissues. High-throughput RNA sequencing bioinformatic...
F-box proteins are important components of eukaryotic SCF E3 ubiquitin ligase complexes, which specifically determine protein substrate proteasomal degradation during plant growth and development, as well biotic abiotic stress. It has been found that the FBA (F-box associated) family is one largest subgroups widely prevalent plays significant roles in development stress response. However, gene poplar not systematically studied to date. In this study, a total 337 candidate genes were...
Genistein (4', 5, 7-trihydroxyisoflavone) is an isoflavone compound obtained from plants that has potential applications in cancer therapy. However, the molecular mechanism of action genistein on cell apoptosis not well known. In this study, we investigated effect topoisomerase II-alpha (Topo IIalpha), important protein involved processes DNA replication and proliferation. The results revealed inhibition Topo IIalpha expression through regulation Specificity 1 3 may be one reasons for...
Quantitative reverse transcription polymerase chain reaction (qRT-PCR) is the most sensitive technique for evaluating gene expression levels. Choosing appropriate reference genes normalizing target important verifying changes. Metasequoia a high-quality and economically wood species. However, few systematic studies have examined in Metasequoia. Here, stability of 14 candidate different tissues following hormone treatments were analyzed using six algorithms. Candidate used to normalize...
Topoisomerase IIβ (top IIβ) is a nuclear enzyme with an essential role in neural development. The regulation of top gene expression during differentiation poorly understood. Functional analysis structure displayed GC box sequence its transcription promoter, which binds the factor specificity protein 1 (Sp1). Sp1 regulates via multiple mechanisms and for early embryonic This study seeks to determine whether neuronal differentiation. For this purpose, human neuroblastoma SH‐SY5Y cells were...
Abstract According to our previous studies, bta‐miR‐152, PRKAA1 and UCP3 are differentially expressed in mammary gland tissues of high milk fat low cows, the trend bta‐miR‐152 expression is opposite from those . To further identify function regulatory mechanism metabolism, we investigated effect on cellular triglyceride content bovine epithelial cells cultured vitro, basis overexpression inhibition assays. The target genes were identified through qPCR, Western blotting dual luciferase...
According to our previous studies, bta-miR-124a was differentially expressed in breast tissue between high-fat and low-fat dairy cows. However, the function of lipid metabolism cows identification its target genes have not been reported. Therefore, this study will identify gene explore role regulation milk metabolism. First, preliminary bioinformatics prediction candidate performed, quantitative real-time polymerase chain reaction (qRT-PCR) used analyze relative expression changes level...
Plant endophytic bacteria play important roles in plants' growth and resistance to stress. It is characterize be able understand their benefits. Matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) has become a powerful technique for bacterial identification due its high throughput simple procedures. In this study, the separated from Populus (the leaves, roots stems tomentosa Carrière; nigra Linn. var. nigra; canadensis Moench) were identified...