A5064273123- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Neuropeptides and Animal Physiology
- Inflammasome and immune disorders
- Lipid Membrane Structure and Behavior
- Autophagy in Disease and Therapy
- Cancer-related molecular mechanisms research
- Memory and Neural Mechanisms
- Visual perception and processing mechanisms
- Sphingolipid Metabolism and Signaling
- Ginseng Biological Effects and Applications
- Pain Mechanisms and Treatments
- Retinal Development and Disorders
- Immune Response and Inflammation
- Lung Cancer Research Studies
- Neurotransmitter Receptor Influence on Behavior
- Neuroblastoma Research and Treatments
- Nicotinic Acetylcholine Receptors Study
- Cancer therapeutics and mechanisms
- interferon and immune responses
- Neural and Behavioral Psychology Studies
- Photoreceptor and optogenetics research
- NF-κB Signaling Pathways
- Neuroscience and Neural Engineering
Shanghai Tenth People's Hospital
2024-2025
Tongji University
2012-2025
Kunming Medical University
2024
Hefei National Center for Physical Sciences at Nanoscale
2023
Chinese Academy of Sciences
2023
University of Science and Technology of China
2023
Hebei Medical University
2012-2014
Down-regulation of GABAergic inhibition may result in the generation epileptiform activities. Besides spike-triggered synchronous GABA release, changes asynchronous release (AR) following high-frequency discharges further regulate In brain slices obtained from surgically removed human neocortical tissues patients with intractable epilepsy and tumor, we found that AR occurred at output synapses fast-spiking (FS) neurons its strength depended on type connections, FS autapses showing strongest...
ABSTRACT Background Periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome has been considered as a childhood syndrome. Its etiopathogeny is unknown however, currently auto‐immune inflammatory disease. Recently, few cases of adult‐onset PFAPA have reported. However, there no report about the case with novel TNFAIP3 Mutation. Objective Method Followed by detailed clinical inquiry, related laboratory tests, genetic sequencing treatment, we reported mutation....
Opioid analgesic tolerance, a root cause of opioid overdose and misuse, can develop through an associative learning. Despite intensive research, the locus central pathway subserving tolerance (AOAT) remains unclear. Using combination chemo/optogenetic manipulation with calcium imaging slice physiology, here we identify neuronal ensembles in hierarchically organized essential for AOAT. The association morphine-induced analgesia environmental condition drives glutamatergic signaling from...
Neuropeptide Y (NPY) is a potent modulator of excitatory synaptic transmission and limbic seizures. NPY abundantly expressed in the dentate gyrus thought to modulate hippocampal excitability via activation presynaptic Y2 receptors (Y2R). Here we demonstrate that NPY, commonly used Y2R-preferring (NPY 13–36 ) Y5 receptor (Y5R)–preferring ([d-Trp 32 ]NPY hPP) peptide agonists, evoke similar levels inhibition at CA3 synapses slices from wild-type control mice (WT). In contrast, NPYergic absent...
Abstract Background The aim of this study was to investigate whether serotonin (5-hydroxytryptamine, 5-HT) can modulate Na + /K pump in rat hippocampal CA1 pyramidal neurons. Results 5-HT (0.1, 1 mM) showed current (Ip) densities 0.40 ± 0.04, 0.34 0.03 pA/pF contrast 0.63 0.04 the control 0.5 mM strophanthidin (Str), demonstrating 5-HT-induced inhibition Ip a dose-dependent manner effect partly attenuated by ondasetron, 3 receptor (5-HT R) antagonist, not WAY100635, 1A R while...
Topoisomerase IIβ (top IIβ) is a nuclear enzyme with an essential role in neural development. The regulation of top gene expression during differentiation poorly understood. Functional analysis structure displayed GC box sequence its transcription promoter, which binds the factor specificity protein 1 (Sp1). Sp1 regulates via multiple mechanisms and for early embryonic This study seeks to determine whether neuronal differentiation. For this purpose, human neuroblastoma SH‐SY5Y cells were...
Both hemispheres connect with each other by excitatory callosal projections, and whether inhibitory interneurons, usually believed to have local innervation, engage in transcallosal activity modulation is unknown. Here, we used optogenetics combination cell-type-specific channelrhodopsin-2 expression activate different neuron subpopulations the visual cortex recorded response of entire using intrinsic signal optical imaging. We found that optogenetic stimulation neurons reduced spontaneous...
background:Periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA) syndrome has been considered as a childhood syndrome. Its etiopathogeny is unknown however, currently auto-immune inflammatory disease. Recently, few cases of adult-onset PFAPA have reported. However, there no report about the case with novel TNFAIP3 Mutation. Objective Method: Followed by detailed clinical inquiry, related laboratory tests, genetic sequencing treatment, we reported Results:we found...
Abstract Background Perceptual learning refers to an augmentation of organism’s ability respond external stimuli, which has been described in most sensory modalities. Visual perceptual (VPL) is a manifestation plasticity visual information processing that occurs the adult brain, and can be used ameliorate patients with defects mainly based on improvement detection or discrimination features tasks. While some brain regions such as primary cortex have participate VPL, way more general...