A5024178292- Advancements in Transdermal Drug Delivery
- Ear and Head Tumors
- Head and Neck Cancer Studies
- interferon and immune responses
- Salivary Gland Tumors Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Bone Metabolism and Diseases
- Orthopaedic implants and arthroplasty
- Drug Solubulity and Delivery Systems
- Ginseng Biological Effects and Applications
- Ferroptosis and cancer prognosis
- Advanced Drug Delivery Systems
- Immune Response and Inflammation
- Cell death mechanisms and regulation
- Bone Tissue Engineering Materials
- Trace Elements in Health
- Endoplasmic Reticulum Stress and Disease
- Essential Oils and Antimicrobial Activity
- Invertebrate Immune Response Mechanisms
- Plant Micronutrient Interactions and Effects
- Bone health and treatments
- Food Quality and Safety Studies
- TGF-β signaling in diseases
- Chemotherapy-induced organ toxicity mitigation
- Phagocytosis and Immune Regulation
Shanghai Stomatological Hospital
2014-2024
Nanjing University of Chinese Medicine
2024
Jiangsu Province Hospital
2024
Nanjing Medical University
2024
Affiliated Hospital of Nantong University
2023-2024
Nantong University
2023-2024
Binzhou People's Hospital
2023-2024
Fudan University
2019-2023
Beijing Forestry University
2016-2022
Henan University Huaihe Hospital and Huaihe Clinical Institute
2021
In clinic, strontium ranelate (SrR) is a useful drug to treat osteoporosis by orally taken method, but some side effect appeared in recent years.The aim of this study evaluate the effectiveness and safety SrR on cells direct application, possibility local application drug.Qualitative ALP staining, quantitative activity assay, alizarin red realtime PCR westernblot assay were used osteogenesis ability under normal or osteogenic induction environment ovariectomy bone marrow mesenchymal stem...
Background: Oral squamous cell carcinoma (OSCC) is the most common cancer of oral and maxillofacial region. A recent clinical research has shown that tumor immune microenvironment (TIME)cells are closely related to immunotherapy sensitivity OSCC prognosis. Nonetheless, a comprehensive analysis TIME in not been reported. Methods: Bioinformatics computational algorithms were employed determine significance cells 257 patients. scores measured by three models, then used evaluate prognosis...
This work aimed to develop a sustained release solid dispersion of ivermectin (IVM-SD) in lipid matrix (hydrogenated castor oil, HCO) for subcutaneous delivery. Solvent-melting technology was employed prepare IVM-SDs using HCO. The physicochemical properties the were evaluated by scanning electron microscopy (SEM), X-ray powder diffraction (XRPD), and Fourier transform infrared spectroscopy (FTIR). IVM from with HPLC vitro. Pharmacokinetics studied rabbits following single administration...
Accumulating evidence demonstrates the superior osteoinductivity of tantalum (Ta) to that titanium (Ti); however, mechanisms underlying these differences are unclear. Thus, objective present study was examine effects Ta and Ti surfaces on osteogenesis using rat bone mesenchymal stromal cells (rBMSCs) as a model.Ta substrates were polished mirror finish minimize influences structural factors, intrinsic surface two materials integrin α5β1/mitogen-activated protein kinases 3 1 (ERK1/2)...
A florfenicol-loaded solid lipid nanoparticle (FFC-SLN) suspension was prepared by hot homogenisation and ultrasonic technique. The characterised for its release profile, stability, toxicity, the physicochemical properties of nanoparticles. Antibacterial activity evaluated in vitro vivo. results showed that mean diameter, polydispersity index zeta potential nanoparticles were 253 ± 3 nm, 0.409 0.022 47.5 0.21 mV, respectively. In profile FFC-SLN had sustained effect. minimum inhibition...
Three tilmicosin-loaded hydrogenated castor oil nanoparticle (TMS-HCO-NP) suspensions of different particle sizes were prepared with polyvinyl alcohol surfactant concentrations using a hot homogenization and ultrasonic technique. The in vitro release, antibacterial activity, mammalian cytotoxicity, acute toxicity mice, stability study conducted to evaluate the characteristics suspensions. tilmicosin release rate, evaluated. When 0.2%, 1%, 5%, mean diameters nanoparticles three 920±35 nm,...
Lymph node metastasis is one of the most important factors affecting prognosis tongue cancer, and molecular mechanism regulating lymph cancer poorly known.The gene expression dataset GSE2280 The Cancer Genome Atlas (TCGA) were downloaded. R software was used to identify differentially expressed hallmark sets individual genes between metastatic tissues primary tissues, Kaplan-Meier method evaluate association with overall survival. screening validation functional performed using western blot,...
Esophageal squamous cell carcinoma (ESCC) is the most predominant primary malignant tumor among worldwide, especially in China. To date, successful treatment remains a mainly clinical challenge, it imperative to develop therapeutic agents.The anti-proliferative effect of ivermectin on ESCC investigated model and nude mice model. Cell apoptosis was assessed using flow cytometry, TUNEL assay western blotting. Mitochondrial dysfunction determined by reactive oxygen species accumulation,...
Abstract Background To explore the clinicopathologic characteristics, treatment and prognostic factors of head neck acinar cell carcinoma (HNACC) comprehensively. Methods A population-based study was conducted using data from Surveillance, Epidemiology, End Results database (1975–2016). Overall survival (OS) HNACC-specific patients with different variables were compared Kaplan-Meier method Cox multivariate regression. total 2624 primary HNACC cases (1052 males, 1572 females) identified....
e regulation of protein kinase B (AKT) phosphorylation by Tripartite motif-containing 31 (TRIM31) is implicated as an essential mechanism in the progression many malignant tumors.Nevertheless, function TRIM31/ AKT pathway oral squamous cell carcinoma (OSCC) remains elusive.Here, immunohistochemistry analysis human OSCC tissue microarrays indicated signi cantly higher levels TRIM31 and phosphorylated (p-AKT) tumors than adjacent samples.Also, we detected a positive association between...
Abstract Background To investigate the clinicopathological characteristics of head and neck small cell carcinoma (H&NSmCC) identify prognostic factors on basis Surveillance, Epidemiology End Results (SEER) database. Methods Total 789 primary cases from 1973 to 2016 were included. Univariate multivariate analyses performed independent indicators. An H&NSmCC-specific nomogram was constructed compared with AJCC staging system by calculating time-dependent area under curve (AUC) receiver...
The incidence of oral squamous cell carcinoma (OSCC) is increasing, with an estimated 369,000 new patients each year worldwide. Surgery the primary treatment modality for early-stage OSCC, but there scant evidence to prove value elective neck dissection (END) relatively small OSCC. This study aimed identify factors predicting survival clinical stage T1N0M0 (cT1N0M0) OSCC and whether up-front END improved survival.Patients cT1N0M0 who underwent tumor resection or without were identified...