A5100362956- Trace Elements in Health
- RNA regulation and disease
- Parkinson's Disease Mechanisms and Treatments
- Fatty Acid Research and Health
- Infant Nutrition and Health
- Multiferroics and related materials
- Magnetic and transport properties of perovskites and related materials
- Cell death mechanisms and regulation
- Intestinal Malrotation and Obstruction Disorders
- Advanced Condensed Matter Physics
- Alzheimer's disease research and treatments
- Phytase and its Applications
- Electrical and Thermal Properties of Materials
- Cholesterol and Lipid Metabolism
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Neurological diseases and metabolism
- Autophagy in Disease and Therapy
- Hemoglobinopathies and Related Disorders
- Pomegranate: compositions and health benefits
- Polysaccharides Composition and Applications
- Clinical Nutrition and Gastroenterology
- Dialysis and Renal Disease Management
- Heavy Metals in Plants
- Coenzyme Q10 studies and effects
- Iron Metabolism and Disorders
National University of Singapore
2015-2024
Ministry of Agriculture and Rural Affairs
2022-2023
Shandong Academy of Agricultural Sciences
2022-2023
Zunyi Medical University
2022
Children's Hospital of Capital Institute of Pediatrics
2022
PLA Academy of Military Science
2021
National Clinical Research Center for Digestive Diseases
2021
State Key Laboratory of Kidney Diseases
2021
Xuzhou Medical College
2019-2020
Affiliated Hospital of Jiangsu University
2018
Amyloid precursor protein (APP) is commonly associated with Alzheimer disease, but its physiological function remains unknown. Nav1.6 a key determinant of neuronal excitability in vivo. Because mouse models gain and loss APP share some similar phenotypes, we hypothesized that might be candidate molecule for sodium channel modulation. Here report colocalized interacted cortical neurons. Knocking down decreased currents cell surface expression. APP-induced increases expression were Go...
Axonal injury is a common feature of central nervous system insults. Upregulation amyloid precursor protein (APP) observed following neurotrauma and regarded as marker axonal injury. However, the underlying mechanism by which APP mediates neuronal death remains to be elucidated. Here, we used mouse optic nerve axotomy (ONA) model replicating aspects retinal ganglion cell (RGC) in neuropathies. intracellular domain (AICD) were upregulated retina after ONA knockout reduced Tuj1+ RGC loss....
Elevated iron deposition has been reported in Parkinson's disease (PD). However, the route of uptake leading to high substantia nigra is unresolved. Here, we show a mechanism enhanced Fe 2+ via S-nitrosylation divalent metal transporter 1 (DMT1). While DMT1 could be S-nitrosylated by exogenous nitric oxide donors, human PD brains, endogenously was detected postmortem nigra. Patch-clamp electrophysiological recordings and assays confirmed increased Mn or through DMT1. We identified two major...
The study aimed to characterize physicochemical, thermal, and rheological properties of cashew nut starch (CNS) then compare the obtained results with potato corn starches. CNS showed higher gelatinization temperatures (112.29 °C) than those noted for maize starches (78.44-94.65 °C). In addition, had peak viscosity (19.03 mPa·s) high amylose starch. static shear test indicated that followed a pseudoplastic behavior. sample thixotropic patter, which was less pronounced observed starch, but...
Leptin (LEP) and LEP receptor (LEPR) polymorphisms may be associated with the development of cancer.In this study, we selected five functional LEPR single-nucleotide (SNPs) conducted a case-control study to determine relationship hepatocellular carcinoma (HCC) risk in Eastern Chinese Han population. There were 584 HCC cases 923 cancer-free controls included our study. patients fully matched by age sex. SNPscan™ genotyping method was used analyze rs2167270 G>A, rs7799039 A>G, rs6588147...
Background. To find the predictor of optimal surgical timing for neonatal necrotizing enterocolitis (NEC) patients by analyzing risk factors conservative treatment and therapy. Methods. Data were collected from 184 NEC (Surgery, n=41; treatment, n=143) between years 2015 2019. analyzed univariate analysis, multivariate binary logistic regression analysis. Results. Univariate analysis showed that statistically significant differences surgery groups. The results Logistic indicated intestinal...
Structural domains in ferroic materials can be manipulated to achieve novel properties and functionalities of devices with multiple tunabilities. Herein, we report a study tunable domain structures ferroelastic ${\mathrm{La}}_{0.67}{\mathrm{Sr}}_{0.33}{\mathrm{MnO}}_{3}$ (LSMO) films via interfacial engineering. Distinct are formed rhombohedral LSMO depending on the crystallographic orientations orthorhombic ${\mathrm{NdGaO}}_{3}$ (NGO) substrates. A unidirectional lattice modulation is...
The current indications based on the clinicopathological parameters for predicting need surgery in neonatal necrotizing enterocolitis (NEC) are still limited. This study retrospectively analyzes characteristics of NEC and aims to identify risk factors surgical intervention NEC.Data cases from 2015 2019 were collected our institution divided into two groups: group (n = 41) conservative treatment 143). Clinical, physical, laboratory measures analyzed by univariate analysis multivariate...
Correction for ‘20.7% highly reproducible inverted planar perovskite solar cells with enhanced fill factor and eliminated hysteresis’ by Xixia Liu <italic>et al.</italic>, <italic>Energy Environ. Sci.</italic>, 2019, DOI: 10.1039/c9ee00872a.
This study aimed to explore whether zinc-selenium tea has an curative effect on the cardiotoxicity induced by nonylphenol (NP), and compare of green tea. After drinking or tea, compared with control group, left ventricular anterior wall became thinner, end-diastolic diameter increased, ventricle thin at end diastole in NP group. The serum myocardial enzymes aspartate aminotransferase, creatine kinase, kinase isoenzyme, lactate dehydrogenase, α-hydroxybutyrate dehydrogenase group were...
Abstract Understanding intrinsic exchange bias in nominally single‐component ferromagnetic or ferrimagnetic materials is crucial for simplifying related device architectures. However, the mechanisms behind this phenomenon and its tunability remain elusive, which hinders efforts to achieve unidirectional magnetization widespread applications. Inspired by high of inverse spinel NiCo 2 O 4 , origin (111) films deposited on Al 3 (0001) substrates are investigated. The comprehensive...
Abstract Mammalian Target of Rapamycin (mTOR) is a master regulator autophagy and lysosomes, its downstream kinase-dependent pathways have been extensively characterized. Here, we report an unexpected kinase-independent regulation lysosomes by S-nitrosylation at Cys423 position mTOR that resulted in suppression VPS34 PIKfyve-dependent phosphoinositide synthesis. Physiologically, reduced basal lysosomal proteolysis via nitric oxide synthase (NOS)-mediated synthesis NO from arginine precursor,...
A new class of 2-acetyl-1,3-diacyl-sn-glycerols (sn-2-acTAG) was found in the seed oil Polygala previously. Its structure is very similar to sn-1,3-DAG, which has effect preventing and treating hyperlipidemia other diseases. In this study, sn-2-acTAG enriched confirmed, safety hypolipidemic activity assessed. addition mechanism action investigated. Our study indicated that a diet containing 20% or lower not toxic SD rats. Compared soybean group, could total cholesterol, triglyceride,...