A5090357799- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Neurotransmitter Receptor Influence on Behavior
- Pregnancy-related medical research
- Receptor Mechanisms and Signaling
- Neuroscience and Neural Engineering
- Neurogenesis and neuroplasticity mechanisms
- Alzheimer's disease research and treatments
- Advanced Memory and Neural Computing
- Nicotinic Acetylcholine Receptors Study
- Stress Responses and Cortisol
- Genetics and Neurodevelopmental Disorders
- Analog and Mixed-Signal Circuit Design
- Photoreceptor and optogenetics research
- Prenatal Screening and Diagnostics
- Epigenetics and DNA Methylation
- Mast cells and histamine
- Tissue Engineering and Regenerative Medicine
- Neuroinflammation and Neurodegeneration Mechanisms
- Occupational Health and Performance
- Neuroendocrine regulation and behavior
- Sulfur Compounds in Biology
- Anesthesia and Neurotoxicity Research
- Mitochondrial Function and Pathology
- Neurological Disease Mechanisms and Treatments
National University of Singapore
2016-2025
National University Health System
2010-2019
Singapore Institute of Technology
2013-2018
Imperial College London
2015
Yale University
2015
University of Helsinki
2015
Yong In University
2008-2014
University Health System
2012-2014
Centre for Life
2008-2013
Institute of Pharmacology
2013
Parkinson's disease (PD) is a neurodegenerative disorder characterized by progressive loss of dopaminergic neurons in the substantia nigra (SN). The present study was designed to examine therapeutic effect hydrogen sulfide (H(2)S, novel biological gas) on PD. endogenous H(2)S level markedly reduced SN 6-hydroxydopamine (6-OHDA)-induced PD rat model. Systemic administration NaHS (an donor) dramatically reversed progression movement dysfunction, tyrosine-hydroxylase positive and elevated...
Neural prosthetics and personal healthcare have increasing need of high channel density low noise power neural sensor interfaces. The input referred quantization resolution are two essential factors which prevent conventional interfaces from simultaneously achieving a good efficiency factor consumption. In this paper, recording architecture with dynamic range folding current reuse techniques is proposed dedicated to solving the trade-off under voltage operation. Measured results silicon...
This paper presents a fully implantable 100-channel neural interface IC for activity monitoring. It contains analog recording front-ends, 10 multiplexing successive approximation register ADCs, digital control modules and power management circuits. A dual sample-and-hold architecture is proposed, which extends the sampling time of ADC reduces average per channel by more than 50% compared to conventional system. amplifier (NA) with current-reuse technique weak inversion operation...
Sorting nexin 27 (SNX27), a PDZ domain-containing endosomal protein, was recently shown to modulate glutamate receptor recycling in Down's syndrome. However, the precise molecular role of SNX27 GluA1 trafficking is unclear. Here we report that enriched dendrites and spines, along with endosomes. Significantly, mobilization endosomes into spines observed. Mechanistically, interacts K-ras GTPase via RA domain; following chemical LTP stimuli, recruited SNX27-enriched through...
Abstract Near‐infrared (NIR) activatable upconversion nanoparticles (UCNPs) enable wireless‐based phototherapies by converting deep‐tissue‐penetrating NIR to visible light. UCNPs are therefore ideal as wireless transducers for photodynamic therapy (PDT) of deep‐sited tumors. However, the retention unsequestered in tissue with minimal options removal limits their clinical translation. To address this shortcoming, biocompatible implants developed deliver photonic properties a flexible, optical...
We investigated whether fetal cells can enter the maternal brain during pregnancy. Female wild-type C57BL/6 mice were crossed with transgenic Green Mice ubiquitously expressing enhanced green fluorescent protein (EGFP). Mouse found in brain. Quantitative real-time polymerase chain reaction (PCR) of genomic DNA for EGFP gene showed that more present 4 weeks postpartum than on day parturition. After an excitotoxic lesion to brain, detected injured region. The presence was also confirmed by...
Abstract Hydrogen sulphide (H 2 S), which is produced endogenously from L ‐cysteine in mammalian tissues, has been suggested to function as a neuromodulator the brain. However, role of H S microglial cells unclear. In this study, effect exogenous and endogenous on intracellular calcium homeostasis was investigated primary cultured cells. Sodium hydrosulphide (NaHS), donor, caused concentration‐dependent (0.1–0.5 mM) increase concentration ([Ca 2+ ] i ). This significantly attenuated presence...
Neurons and glia in the vertebrate central nervous system arise temporally distinct, albeit overlapping, phases. are generated first followed by astrocytes oligodendrocytes from common progenitor cells. Increasing evidence indicates that axon-derived signals spatiotemporally modulate oligodendrocyte maturation myelin formation. Our previous observations demonstrate F3/contactin is a functional ligand of Notch during maturation, revealing existence another group ligands. Here, we establish...
The aberrant hyperactivation of Cyclin-dependent kinase 5 (Cdk5), by the production its truncated activator p25, results in formation hyperphosphorylated tau, neuroinflammation, amyloid deposition, and neuronal death vitro vivo . Mechanistically, this occurs as a result neurotoxic insult that invokes intracellular elevation calcium to activate calpain, which cleaves Cdk5 p35 into p25. It has been shown previously p25 transgenic mouse model investigate mechanistic implications brain,...
Abstract Amyloid precursor protein (APP) is best known for its involvement in the pathogenesis of Alzheimer’s disease. We have previously demonstrated that APP intracellular domain (AICD) regulates neurogenesis; however, mechanisms underlying AICD-mediated regulation neuronal differentiation are not yet fully characterized. Using genome-wide chromatin immunoprecipitation approaches, we found AICD specifically recruited to regulatory regions several microRNA genes, and acts as a...
Fetal cells migrate into the mother during pregnancy. Fetomaternal transfer probably occurs in all pregnancies and humans fetal can persist for decades. Microchimeric are found various maternal tissues organs including blood, bone marrow, skin liver. In mice, have also been brain. The appear to target sites of injury. microchimerism may important implications immune status women, influencing autoimmunity tolerance transplants. Further understanding ability cross both placental blood-brain...
Bidirectional cell trafficking between fetus and mother during pregnancy is a well-established phenomenon observed in placental vertebrates including humans. Although studies have shown that transmigratory fetal cells, also termed pregnancy-associated progenitor cells (PAPCs), can integrate into multiple maternal organs, the integration, long-term survival, differentiation of PAPCs brain has not been extensively studied. Using murine model fetomaternal microchimerism, we show integrated...
Abstract Stem cell transplantation for regenerative medicine has made significant progress in various injury models, with the development of modalities to track stem fate and migration post-transplantation being currently pursued rigorously. Magnetic resonance imaging (MRI) allows serial high-resolution vivo detection transplanted cells labeled iron oxide particles, but been hampered by low labeling efficiencies. Here, we describe use microgel (MGIO) particles diameters spanning 100-750 nm...
Parkinson's disease (PD), characterized by loss of dopaminergic neurons in the substantia nigra, is a neurodegenerative disorder central nervous system. The present study was designed to investigate therapeutic effect ACS84, hydrogen sulfide-releasing-L-Dopa derivative compound, 6-hydroxydopamine (6-OHDA)-induced PD model. ACS84 protected SH-SY5Y cells against 6-OHDA-induced cell injury and oxidative stress. protective resulted from stimulation Nrf-2 nuclear translocation promotion...
Selective serotonin reuptake inhibitors (SSRIs) are the most commonly used psychopharmaceutical treatment for major depressive disorder (MDD), but individual responses to SSRIs vary greatly. CYP2C19 is a key enzyme involved in metabolism of several drugs, including SSRIs. Variations gene associated with differential metabolic activity, and thus SSRI exposure; accordingly, genotype may affect therapeutic response clinical outcomes, though existing evidence this link not entirely consistent....
Conventional neural-recording systems face limitations in simultaneously achieving a good NEF and low power consumption [1-4]. This is because the input amplifier current dictated by an input-referred noise requirement that determines system sensitivity, while supply voltage determined DR at analog recording chain output limits maximum achievable resolution of A-to-D conversion. In this paper, power-efficient architecture using DR-folding technique presented to enable low-voltage operation...