A5025503166- Genomics and Chromatin Dynamics
- Chromosomal and Genetic Variations
- Immune Cell Function and Interaction
- Genomics and Phylogenetic Studies
- Nematode management and characterization studies
- Soil Carbon and Nitrogen Dynamics
- Pharmaceutical and Antibiotic Environmental Impacts
- Environmental Toxicology and Ecotoxicology
- Protein Interaction Studies and Fluorescence Analysis
- Gastric Cancer Management and Outcomes
- Helicobacter pylori-related gastroenterology studies
- Animal Nutrition and Physiology
- Identification and Quantification in Food
- CRISPR and Genetic Engineering
- Esophageal Cancer Research and Treatment
- Single-cell and spatial transcriptomics
- Aquaculture disease management and microbiota
- High-Temperature Coating Behaviors
- Pesticide and Herbicide Environmental Studies
- Lipid metabolism and disorders
- Ichthyology and Marine Biology
- Biochemical Analysis and Sensing Techniques
- Metal and Thin Film Mechanics
- PI3K/AKT/mTOR signaling in cancer
- High Entropy Alloys Studies
Sun Yat-sen University
2022-2025
Hangzhou Normal University
2023
Kunming University of Science and Technology
2016-2023
Huazhong Agricultural University
2016-2021
Hunan Children's Hospital
2021
Institute of Applied Ecology
2019-2021
Chinese Academy of Sciences
2019-2021
University of Chinese Academy of Sciences
2019-2021
Lincoln University
2020
Central South University
2016-2018
Abstract Chromatin loops connect regulatory elements to their target genes. They serve as bridges between transcriptional regulation and phenotypic variation in mammals. However, spatial organization of its impact on gene expression plants remain unclear. Here, we characterize epigenetic features active promoter proximal regions candidate distal construct high-resolution chromatin interaction maps for maize via long-read analysis by paired-end tag sequencing (ChIA-PET). The indicate that are...
Chromatin topology can impact gene regulation, but how evolutionary divergence in chromatin has shaped regulatory landscapes for distinctive human traits remains poorly understood. CTCF sites determine by forming domains and loops. Here, we show CTCF-mediated at the domain loop scales during primate evolution, elucidating distinct mechanisms shaping landscapes. Human-specific divergent lead to a broad rewiring of transcriptional Divergent loops concord with species-specific enhancer...
Background/Aims: Oxidized low-density lipoprotein (oxLDL) promotes unregulated platelet activation in patients with dyslipidemic disorders. Although oxLDL stimulates activating signaling, researchers have not clearly determined how these events drive accelerated thrombosis. Here, we describe the mechanism by which ROS regulate autophagy during ox-LDL-induced modulating PI3K/AKT/mTOR signaling pathway. Methods: For vitro experiments, ox-LDL, scavenger N-acetylcysteine (NAC), mTOR inhibitor...
Abstract: The aim of the present study was to develop a novel dosage form multivesicular liposomes for oleanolic acid (OA) overcome its poor solubility, prolong therapeutic drug levels in blood, and enhance antitumor effect on hepatocellular carcinoma. OA-encapsulated (OA-MVLs) were prepared by double-emulsion method, formulation optimized central composite design. morphology, particle size, drug-loading efficiency OA-MVLs investigated. Furthermore, also characterized both vitro vivo....
Abstract Aim Increasing aridity under global change is predicted to have a profound impact on the structure and functioning of terrestrial ecosystems, yet we poor understanding how belowground communities respond. In order understand longer term responses different trophic levels in soil food web increasing aridity, investigated abundance, richness community similarity nematode along 3,200 km gradient. Location A transect across semi‐arid arid grasslands Northern China, where ranges from .43...
Abstract Extensive epigenetic reprogramming involves in memory CD8+ T-cell differentiation. The elaborate rewiring underlying the heterogeneous functional states of T cells remains hidden. Here, we profile single-cell chromatin accessibility and map enhancer-promoter interactomes to characterize differentiation trajectory cells. We reveal that under distinct regulations, early activated divergently originated for short-lived effector precursor also uncover a defined leading conversion from...
This work aimed to develop a sustained release solid dispersion of ivermectin (IVM-SD) in lipid matrix (hydrogenated castor oil, HCO) for subcutaneous delivery. Solvent-melting technology was employed prepare IVM-SDs using HCO. The physicochemical properties the were evaluated by scanning electron microscopy (SEM), X-ray powder diffraction (XRPD), and Fourier transform infrared spectroscopy (FTIR). IVM from with HPLC vitro. Pharmacokinetics studied rabbits following single administration...
Abstract Understanding biogeographic patterns of community assemblages is a core objective in ecology, but for soil communities these are poorly understood. To understand the spatial and underlying mechanisms β ‐diversity communities, we investigated nematode along 3,200‐km transect across semi‐arid arid grasslands. Spatial turnover nested‐resultant two fundamental components ‐diversity, which have been attributed to various processes assembly. We calculated based on ‐partitioning framework....
By weak conjugation, stable near-ultraviolet (NUV) emitters are prepared for organic light-emitting diodes fabrication and highly pure NUV electroluminescence with small efficiency roll-off is achieved narrowed full-width at half maxima.
BACKGROUND The development and progression of hepatocellular carcinoma (HCC) are associated with obesity hepatosteatosis. AMP-activated protein kinase (AMPK) regulates metabolic homeostasis. This study aimed to investigate the effects treatment adenosine monophosphate (AMP) analog, 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) on hepatosteatosis in a mouse model fed high-fat diet (HFD), induced by diethylnitrosamine (DEN) HFD model. MATERIAL AND METHODS Male C57BL/6 male mice from...
A variety of algorithms have been developed for catalytic residue prediction based on either feature- or template-based methodology. However, no studies systematically compared these two strategies and further considered whether their combination could improve the performance. Herein, we an integrative algorithm named CRHunter by simultaneously using complementarity between methodologies that structural sequence information. Several novel features were generated Delaunay triangulation...
Pseudorabies virus interacts with active regions in host genome to efficiently transcribe viral genes.
The microRNAs miR-17-5p and miR-20a-5p play important roles on angiogenesis; however, it is arguable whether they regulate the formation of retinal blood vessels in retinopathy prematurity (ROP). We used a mouse model oxygen-induced (OIR) to simulate development retinas mice suffering from ROP, expression levels miR-20a-5p, miR-17-5p, hypoxia-inducible factor 1-alpha (HIF-1α), vascular endothelial growth (VEGF) were measured by RT-qPCR Western blotting. Cell proliferation, apoptosis,...
Biomorphic nano-hydroxyapatite (HAP) was fabricated by a co-precipitation method using cotton as bio-templates and employed in adsorptive removal of ofloxacin (OFL) triclosan (TCS) that are two representative pharmaceuticals personal care products (PPCPs). The surface area porosity, crystal phase, functional group, morphology micro-structure the synthesized HAP were characterized Brunauer–Emmett–Teller isotherm, X-ray powder diffraction, Fourier transform infrared spectroscopy, scanning...
The 5′-Adenosine-monophosphate -activated protein kinase plays a key role in regulating cellular energy homeostasis, and it was reported that nucleotide variants the genes coding were associated with meat quality. In present study, genetic variations exons of gamma non-catalytic subunit screened among 284 White Plymouth Rock chickens from 7 families denaturing gradient gel electrophoresis, their quality traits including drip loss cooked rate which reflect water holding capacity serum...