A5028744783- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Rangeland Management and Livestock Ecology
- Genomics and Chromatin Dynamics
- CRISPR and Genetic Engineering
- interferon and immune responses
- Immune cells in cancer
- Botany, Ecology, and Taxonomy Studies
- Single-cell and spatial transcriptomics
- Cancer, Hypoxia, and Metabolism
- RNA Research and Splicing
Guangzhou Medical University
2025
Southwest Minzu University
2020-2021
Sichuan Academy Of Social Sciences
2020
Chromatin topology can impact gene regulation, but how evolutionary divergence in chromatin has shaped regulatory landscapes for distinctive human traits remains poorly understood. CTCF sites determine by forming domains and loops. Here, we show CTCF-mediated at the domain loop scales during primate evolution, elucidating distinct mechanisms shaping landscapes. Human-specific divergent lead to a broad rewiring of transcriptional Divergent loops concord with species-specific enhancer...
In this study, we designed and evaluated an efficient set of simple sequence repeat (SSR) markers from restriction site-associated DNA (RAD) sequencing data four widely utilized Carex L. accession across Northern China, especially in Beijing. Based on their genomic data, developed 400 SSR amplification specificities among which a total 17 were identified as core molecular for assessment diverse accessions. Using identification system, classified 26 accessions into 3 genetically distinct...
<title>Abstract</title> Background The yak (<italic>Bos grunniens</italic>) is a crucial resource to supply meat and milk the people localized in Tibetan plateau area. To systemically identify lncRNAs regulating metabolism yak, we performed transcriptome analyses simultaneously profile mRNAs of liver under three representative age (<bold>LD</bold>: <bold>L</bold>iver 1 <bold>D</bold>ay, <bold>LM</bold>: 15 <bold>M</bold>onth, <bold>LY</bold>: 5 <bold>Y</bold>ear) conditions. Result Of 288...
Abstract Background: The yak ( Bos grunniens ) is a crucial resource to supply meat and milk the people localized in Qinghai-Tibetan plateau area. To identify lncRNAs regulating metabolism yak, this work adopted transcriptome method simultaneously profile mRNAs of liver under three representative age LD : L iver 1 D ay, LM 15 M onths, LY 5 Y ears) conditions. Result: Of 288 differentially expressed lncRNAs, function-oriented selection yield 88 regulated metabolically related that were at...
Abstract Background IFITM3 is interferon-induced transmembrane 3, which plays an extremely key role in anti-proliferation, anti-virus and anti-tumor diseases. To expand our understanding of the yak, this experiment studied its function. Results Firstly, yak ( Bos grunniens ) BgIFITM3 gene contained a 5’-untranslated region (UTR) (25 bp), coding (441 3’-UTR (115 bp). The expression liver was significantly higher than that heart, spleen, lung kidney P <0.01). protein localized on hepatocyte...