A5103052422- Angiogenesis and VEGF in Cancer
- RNA Research and Splicing
- Schizophrenia research and treatment
- Gastric Cancer Management and Outcomes
- Cancer-related Molecular Pathways
- Robotic Path Planning Algorithms
- Social and Intergroup Psychology
- Genetic Syndromes and Imprinting
- Robotics and Automated Systems
- Single-cell and spatial transcriptomics
- Metabolism, Diabetes, and Cancer
- MicroRNA in disease regulation
- Behavioral Health and Interventions
- CRISPR and Genetic Engineering
- Bacteriophages and microbial interactions
- Lung Cancer Research Studies
- Cancer Research and Treatments
- Decision-Making and Behavioral Economics
- Parathyroid Disorders and Treatments
- Porphyrin Metabolism and Disorders
- Histone Deacetylase Inhibitors Research
- Cancer, Stress, Anesthesia, and Immune Response
- Bone Metabolism and Diseases
- Folate and B Vitamins Research
- Antibiotic Resistance in Bacteria
Shanghai Children's Medical Center
2025
Sun Yat-sen University
2023-2025
Guangzhou Medical University
2025
Kunming Medical University
2017-2025
Chengdu Second People's Hospital
2024
Wenzhou Medical University
2023
Nanjing Agricultural University
2023
United States Department of the Navy
2023
Jimei University
2023
Peking University Sixth Hospital
2021
Abstract Extensive epigenetic reprogramming involves in memory CD8+ T-cell differentiation. The elaborate rewiring underlying the heterogeneous functional states of T cells remains hidden. Here, we profile single-cell chromatin accessibility and map enhancer-promoter interactomes to characterize differentiation trajectory cells. We reveal that under distinct regulations, early activated divergently originated for short-lived effector precursor also uncover a defined leading conversion from...
miR-145-5p regulates drug sensitivity in various cancer types and is also expressed at significantly low levels pancreatic (PC), but its role PC resistance to gemcitabine not yet clear. This study revealed expression of the gemcitabine-resistant cell lines SW1990/GEM PANC-1/GEM. The overexpression inhibited proliferation migration drug-resistant cells. Mechanistically, increased cells through inhibition CDCA3, thereby inhibiting Our indicated that upregulation might be an effective target...
Osteosarcoma, a common malignancy primarily affecting children, generally has poor prognosis. Novel diagnostic, prognostic and therapeutic markers are required to ameliorate the negative outcomes of this disease. We investigated two potential markers, WNT-5a ROR2, which hypothesized dysregulate WNT signaling pathways promote tumorigenesis in other types cancer. ROR2 expression using immunohistochemistry 42 osteosarcoma 12 osteochondroma specimens, compared these proteins with one another as...
The primary objective of our research is to delve into the relationships between sensation seeking (SS), reward sensitivity (RS), and risk adjustment (RA) within context dynamic risk-taking behaviors. By integrating reinforcement learning model neural measures obtained from tasks, we aim explore how these personality traits influence individual decision-making processes engagement in risk-related activities. We dissect cognitive mechanisms underlying this interplay, thereby shedding light on...
Individuals' risk preferences have been shown to influence their decision-making in various contexts. However, the neural mechanisms underlying relationship between preference and a social setting remain unclear. This study utilized functional near-infrared spectroscopy (fNIRS) investigate correlates of dyadic under modulating effect individual preference. examined impact on group using two-phase experimental design. Based G-power software calculations, 168 right-handed participants (62...
Water extract of Goji berries ameliorated neuroinflammation and cognitive impairment in HFFD-induced mice, which might be due to the regulation bile acids (BAs) homeostasis gut microbiota.
Objective Thyroid hormones affect airway contraction, but the specific effects of thyroid on airways are controversial. Methods We divided 78 advanced-age men with asthma into 3 groups: type I respiratory failure (RF1), II (RF2), and no (NRF). Pulmonary function was measured after stabilization. Results The free triiodothyronine (FT3) level significantly higher in RF1 than RF2 group, thyroxine (FT4), total (TT4), thyroid-stimulating hormone (TSH) levels were not different. In RF1, RF2, NRF...
Bioprinting holds the promise of producing biocompatible structures capable seamlessly integrating with human physiology, improving health by enabling precise fabrication tissue models that closely mimic architecture and functions skin, brain, bone. Building on advancements bioprinting, there has been a corresponding increase in cross-disciplinary innovations wearable technologies, brain-machine interfaces, exoskeleton robotics. Given progress bioprinting skin study, electronics are expected...
The aim is to study the expression of PCNA-AS1 in colorectal cancer (CRC) tissue and paired-adjacent normal relationship between its level clinical pathological features.Using real-time qPCR, levels were detected 114 cases establish clinicopathologic features. Moreover, expressions investigated CRC colonic epithelial cell lines.PCNA-AS1 was upregulated patients. difference statistically significant (p < 0.001). significantly correlated with tumor invasion TNM stage. area under receiver...
9060 Background: Dual blockade of PD-1 and CTLA-4 has shown improved overall survival (OS) in combination with a short course chemotherapy. KN046 is novel bispecific antibody that blocks both PD-L1 interaction PD-1/CD80 CD80/CD86. We hypothesized could be combined full chemotherapy build more durable clinical benefit. Methods: This study enrolled systemic treatment naive, stage IV NSCLC patients (pts). Eligible pts received plus platinum doublet until progressive disease, unacceptable...
A 51-year-old female patient with diabetes mellitus and hypertension, exhibiting poor control of blood sugar pressure, was unexpectedly found to have multiple large adrenal nodules, excessive cortisol secretion, adrenocorticotropic hormone inhibition. Cortisol levels remained unresponsive both low-dose high-dose dexamethasone tests, leading a diagnosis primary bilateral macronodular hyperplasia. Concurrently, elevated calcium parathyroid levels, along 99mTc-methoxyisobutyl isonitrile...
Abstract Background: The American Society of Clinical Oncology/College Pathologists recommended that the cut-off for negative status estrogen receptor (ER) should be &lt;1% positively staining cells, although a 10% has often been used clinically. Prior studies reported patients with ER ranging from 1% to 9% showed survival outcomes and molecular features similar those positivity &lt;1%; however, did not take into account patients' human epidermal growth factor 2 (HER2) status. This...
Objective To expore multi-drug resistant Acinetobacter baumannii efflux pump phenotype and gene expression in the isolates. Methods Application of K-B method to detect 96 strains isolated from First Hospital Hebei Medical University baumannii′ resistance 15 kinds antibacterial drugs, detecting with broth microdilution by addition carbonyl cyanide chlorobenzene hydrazone (CCCP) inhibitors,using PCR amplification sequencing study protein sequence characteristics . Results The...
e13566 Background: FDA guidance (2009) recommends that drug development trials use Hy’s Law (a specific pattern of elevated liver enzymes seen in the absence other known causes dysfunction) as a predictor potential drug-induced injury. In populations with high risk underlying disorders (e.g., hepatitis or CA), modified guidelines may be needed. Published reports dysfunction CA pts based on law are sparse. While lab tests (LLT) generally collected trials, not systematically available. This...