A5073065681- Global Cancer Incidence and Screening
- Breast Cancer Treatment Studies
- Cancer Treatment and Pharmacology
- Colorectal Cancer Screening and Detection
- Advanced Breast Cancer Therapies
- Cancer Risks and Factors
- HER2/EGFR in Cancer Research
- Cancer, Lipids, and Metabolism
- Prostate Cancer Treatment and Research
- Chronic Lymphocytic Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Lipoproteins and Cardiovascular Health
- Metabolism, Diabetes, and Cancer
- Diabetes Treatment and Management
- Economic and Financial Impacts of Cancer
- Chemotherapy-induced cardiotoxicity and mitigation
- Schizophrenia research and treatment
- BRCA gene mutations in cancer
- Gastric Cancer Management and Outcomes
- Brain Metastases and Treatment
- Cervical Cancer and HPV Research
- Colorectal Cancer Treatments and Studies
- Diabetes Management and Research
- Inflammatory mediators and NSAID effects
- Pharmaceutical Practices and Patient Outcomes
Boston University
2011-2020
Kaiser Permanente
2004-2014
Henry Ford Hospital
1997-2014
Georgetown University Medical Center
2014
Georgetown University
2014
Marshfield Clinic
2012
Harvard Pilgrim Health Care
2012
Harvard Vanguard Medical Associates
2012
Group Health Cooperative
2004-2012
Southeast Health District
2012
BackgroundClinical trials demonstrated that women treated for breast cancer with anthracycline or trastuzumab are at increased risk heart failure and/or cardiomyopathy (HF/CM), but the generalizability of these findings is unknown. We estimated real-world adjuvant and use their associations incident HF/CM.
Invasive cervical cancer is highly preventable, yet it continues to occur, even among women who have access screening and treatment services. To reduce such women, reasons for its occurrence must be better understood. We examined factors associated with the diagnosis of enrolled in health plans.We identified all cases invasive (n = 833) diagnosed from January 1, 1995, through December 31, 2000, were long-term members seven prepaid comprehensive plans reviewed each woman's medical records 3...
Abstract Purpose: registHER is a prospective, observational study of 1,023 newly diagnosed HER2-positive metastatic breast cancer (MBC) patients. Experimental Design: Baseline characteristics patients with and without central nervous system (CNS) metastases were compared; incidence, time to development, treatment, survival after CNS assessed. Associations between treatment evaluated. Results: Of the 1,012 who had confirmed tumors, 377 (37.3%) metastases. Compared no metastases, those younger...
Abstract Background. The Bevacizumab Regimens’ Investigation of Treatment Effects (BRiTE) study is a prospective, observational cohort designed to elucidate safety and effectiveness outcomes associated with bevacizumab combined chemotherapy as used in clinical practice for first-line treatment metastatic colorectal cancer (mCRC). Patients Methods. Baseline characteristics, prespecified bevacizumab-related adverse events, data were collected from 1,953 mCRC patients who receiving including at...
Five years of adjuvant tamoxifen therapy for estrogen receptor (ER) -positive breast cancer is more effective than 2 use. However, information on discontinuation scanty. We sought to identify predictors among older women with cancer.Within six health care delivery systems, we identified >or= 65 old diagnosed stage I IIB ER-positive or indeterminant between 1990 and 1994 who had filled a prescription tamoxifen. observed them 5 after initial prescription. used automated pharmacy records...
A substantial literature describes age-dependent variations in breast cancer treatment, showing that older women are less likely to receive standard treatment than younger women. We sought identify patient and tumor characteristics associated with the nonreceipt of primary systemic adjuvant therapies.We studied 1,859 age 65 years or stage I II diagnosed between 1990 1994 who were cared for six geographically dispersed community-based health care systems. collected demographic, tumor,...
BACKGROUND: African-American women with breast cancer have poorer survival than European-American women. After adjustment for socioeconomic variables, differences diminish but do not disappear, possibly because of residual in health care access, biology, or behavior. This study compared and similar access. METHODS: We measured who are served by a large medical group metropolitan Detroit maintenance organization where screening, diagnosis, treatment, follow-up based on standard practices...
Background: Mammography screening increases the detection of early-stage breast cancers. Therefore, implementing should reduce percentage women who are diagnosed with late-stage disease. However, despite high national mammography rates, cancers still occur, possibly because failures in implementation. Methods: Using data from seven health care plans that included 1.5 million aged 50 years or older, we conducted retrospective reviews chart and automated for 3 before 1995–1999 diagnoses...
Although hepatitis C virus (HCV) infection has been shown to be associated with development of non-Hodgkin's lymphoma (NHL), few studies have investigated the association between chronic HBV and NHL. The purpose this study was compare incidence NHL patients without B (HBV) infection. Using automated laboratory result clinical data from two United States health systems, we identified individuals January 1, 1995 through December 31, 2001. each system's population-based tumor registry, all...
There are more than 2,000,000 breast cancer survivors in the United States today. While surveillance for asymptomatic recurrence and second primary is included consensus recommendations, effectiveness of this has not been well characterized. Our purpose to estimate mammography a cohort with complete ascertainment mammograms negligible losses follow-up.We enrolled 1,846 stage I II patients who were at least 65 years old six integrated health care delivery systems. We used medical record...
Abstract Purpose To estimate the prevalence of use prescription drugs with a potential for fetal harm among pregnant women in United States. Methods A retrospective study was conducted using automated databases eight health maintenance organizations involved HMO Research Network Center Education and on Therapeutics (CERT). Women who delivered an infant from January 1996 to December 2000 were identified. The frequency based upon expert review clinical teratologist U.S. Food Drug...
Abstract Purpose Calcium channel blockers and beta‐blockers (BBs) are widely used during pregnancy, but data on their safety for the developing infant scarce. We population‐based from 5 HMOs to study risks perinatal complications congenital defects among infants exposed in‐utero. Methods studied women older than 15 years delivering an between 1/1/96 12/31/00, who had been continuously enrolled with prescription drug coverage ≥1 year prior delivery. Information dispensings, inpatient,...
The purpose of this study was to examine the association between atypical antipsychotics, including newer agents, aripiprazole and ziprasidone, newly treated diabetes, using largest post-marketing cohort patients exposed these treatments that has been studied date.Identified two overlapping cohorts-a simple (all antipsychotic users) an inception (new users antipsychotics)-using automated data from three United States sites (60.4 million covered lives). Patients antipsychotics > or = 45 days...
Studies of breast cancer outcomes rely on the identification second events (recurrences and primary tumors). Cancer registries often do not capture recurrences, chart abstraction can be infeasible or expensive. An alternative is using administrative health-care data to identify events; however, these algorithms must validated against a gold standard. We developed from 3152 women in an integrated system who were diagnosed with stage I II 1993–2006. Medical record review served as standard for...
Improvements in screening and adjuvant therapy for breast cancer are associated with decreased recurrence, which may have the effect of increasing proportion patients presenting first-line de novo versus recurrent metastatic (MBC). Here, we describe compare human epidermal growth factor 2 (HER2)-positive MBC. registHER was a prospective observational cohort study (late 2003-early 2006) 1,023 HER2-positive Baseline characteristics, treatment patterns, clinical outcomes were examined newly...
Purpose Primary androgen-deprivation therapy (PADT) is often used to treat clinically localized prostate cancer, but its effects on cause-specific and overall mortality have not been established. Given the widespread use of PADT potential risks serious adverse effects, accurate data are needed inform treatment decisions. Methods We conducted a retrospective cohort study using comprehensive utilization cancer registry from three integrated health plans. All men were newly diagnosed with...
Many pharmacoepidemiologic studies use automated prescription claims data to estimate the association between exposure and disease. One limitation of data, when studying drugs that are also available via retail, is over-the-counter (OTC) missed. The purpose this study quantify effect misclassification OTC in research uses as sole source information.We conducted a sensitivity analysis context non-steroidal anti-inflammatory (NSAIDs) colorectal cancer. following factors were widely varied...
Improvements in cancer detection and treatment have resulted increasing numbers of breast survivors. Information regarding the use mammography by survivors is limited.The surveillance was examined over a 5-year period retrospective cohort women age>or=55 years who were diagnosed with incident primary (1996-1997) while enrolled 1 4 geographically diverse integrated health systems.Of 797 included study, 80% (n=636) underwent mammograms during first year after for cancer. The percentage having...