A5028659209- Herpesvirus Infections and Treatments
- Toxin Mechanisms and Immunotoxins
- Cytomegalovirus and herpesvirus research
- Single-cell and spatial transcriptomics
- Bioinformatics and Genomic Networks
- Bat Biology and Ecology Studies
- Transgenic Plants and Applications
- SARS-CoV-2 and COVID-19 Research
- Genomics and Chromatin Dynamics
- Chromosomal and Genetic Variations
- Cancer Genomics and Diagnostics
- Genomics and Phylogenetic Studies
- Rabies epidemiology and control
- Advanced biosensing and bioanalysis techniques
- Animal Virus Infections Studies
- Mosquito-borne diseases and control
- Virus-based gene therapy research
- Biosensors and Analytical Detection
- interferon and immune responses
- Viral gastroenteritis research and epidemiology
- Animal Disease Management and Epidemiology
- Bacteriophages and microbial interactions
Huazhong Agricultural University
2018-2024
Anyang Institute of Technology
2021
Neurotropic virus-based tracers have been extensively applied in mapping and manipulation of neural circuits. However, their neurotropic neurotoxic properties remain to be fully characterized.Through circuit tracing, we systematically compared the neurotropism discrepancy among different multi-trans-synaptic mono-synaptic retrograde viral including pseudorabies virus (PRV), rabies (RV), newly engineered retro adeno-associated (rAAV2-retro) tracers. The (single-cell) RNA sequencing analysis...
Abstract Background Pseudorabies virus (PRV) causes Aujeszky’s disease or pseudorabies (PR) in pigs worldwide, which leads to heavy economic losses the swine industry. Pigs are natural host, meanwhile, animals such as dogs, cats, foxes, rabbits, cattle and sheep susceptible infection. In 2011, emerging PRV variant led outbreak of PR Bartha-K61 vaccinated pigs. The outbreaks demonstrated that vaccine did not provide full protection against variant. It is widely believed live attenuated could...
Pseudorabies virus interacts with active regions in host genome to efficiently transcribe viral genes.
Abstract Delineating the spatial multiomics landscape will pave way to understanding molecular basis of physiology and pathology. However, current omics technology development is still in its infancy. Here, we developed a high-throughput situ pairwise sequencing (MiP-Seq) strategy efficiently decipher multiplexed DNAs, RNAs, proteins, small biomolecules at subcellular resolution. We delineated dynamic gene profiles hypothalamus using MiP-Seq. Moreover, MiP-Seq was unitized detect tumor...
Abstract Porcine epidemic diarrhea (PED) caused by the porcine virus (PEDV), is a severe infectious and devastating swine disease that leads to serious economic losses in industry worldwide. An increased number of PED cases variant PEDV have been reported many countries since 2010. S protein main immunogenic containing some B-cell epitopes can induce neutralizing antibodies PEDV. In this study, construction, expression purification Pseudomonas aeruginosa exotoxin A (PE) without domain III...
Abstract Background: Pseudorabies virus (PRV) causes Aujeszky’s disease or pseudorabies (PR) in pigs worldwide, which leads to heavy economic losses the swine industry. Pigs are natural host, meanwhile, animals such as dogs, cats, foxes, rabbits, cattle and sheep susceptible infection. In 2011, emerging PRV variant led outbreak of PR Bar-tha-K61-vaccinated pigs. The outbreaks demonstrated that Bartha-K61 vaccine did not provide full protection against variant. It is widely believed...