A5100416791- MicroRNA in disease regulation
- Circular RNAs in diseases
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Bioactive Natural Diterpenoids Research
- Cancer-related gene regulation
- Natural product bioactivities and synthesis
- Traditional and Medicinal Uses of Annonaceae
- Phytochemistry and Biological Activities
- RNA Interference and Gene Delivery
- Polymer Surface Interaction Studies
- Supramolecular Self-Assembly in Materials
- Extracellular vesicles in disease
- Cancer, Hypoxia, and Metabolism
- Cancer Research and Treatments
- Plant-derived Lignans Synthesis and Bioactivity
- Advanced Polymer Synthesis and Characterization
- Metabolism, Diabetes, and Cancer
- CRISPR and Genetic Engineering
- Microbial metabolism and enzyme function
- Luminescence and Fluorescent Materials
- Polyoxometalates: Synthesis and Applications
- Chronic Kidney Disease and Diabetes
- Sesquiterpenes and Asteraceae Studies
Wuhan University
2023-2025
Renmin Hospital of Wuhan University
2023-2025
Heilongjiang Bayi Agricultural University
2016-2024
Chongqing University of Posts and Telecommunications
2024
Shanxi Medical University
2024
Guangdong Medical College
2021-2024
Jilin Agricultural University
2012-2024
Tongji University
2020-2023
Shandong University
2015-2023
Shaoxing People's Hospital
2023
Increasing evidence has revealed a close relationship between non-coding RNAs and cancer progression. Circular (circRNAs), recently identified new member of RNAs, are demonstrated to participate in diverse biological processes, such as development, homeostatic maintenance pathological responses. The functions circRNAs have drawn wide attention recently. Until now, the expression patterns roles hepatocellular carcinoma (HCC) remained largely unknown. Bioinformatics method was used screen...
Abstract Increasing evidence indicates that long non-coding RNAs (lncRNAs) are associated with the progression of human cancers. However, expression level and function LINC01559 (long intergenic non-protein coding RNA 1559) in gastric cancer (GC) rarely reported. Here we found was upregulated GC tissues based on GEPIA (Gene Expression Profiling Interactive Analysis) TCGA (The Cancer Genome Atlas) databases. Also, expressed at a lower cells than mesenchymal stem (MSCs). In vitro experiments...
Depression is a neuropsychiatric disease associated with neuronal anomalies within specific brain regions. In the present study, we screened microRNA (miRNA) expression profiles in dentate gyrus (DG) of hippocampus and found that miR-26a-3p was markedly downregulated rat model depression, whereas upregulation DG regions rescued deterioration depression-like phenotypes resulting from stress exposure, effects appear to be mediated by PTEN pathway. The knockdown normal control rats induced...
Hepatocellular carcinoma (HCC) is the most common type of liver cancer. CircFUT8 has been shown to be upregulated in cancers, but its function HCC remains unclear. Tumor-associated macrophages (TAMs) are one main components tumor microenvironment (TME), and M1 as suppressors cancers. Exosomes exert an important role TME, circRNAs can modified by m6A. We investigated circFUT8 interaction with exosomes, macrophages, m6A.CircFUT8 expression was detected cells, effects on cell growth were...
Tumor metastasis is a hallmark of colorectal cancer (CRC), in which exosome plays crucial role with its function intercellular communication. Plasma exosomes were collected from healthy control (HC) donors, localized primary CRC and liver-metastatic patients. We performed proximity barcoding assay (PBA) for single-exosome analysis, enabled us to identify the alteration subpopulations associated progression. By vitro vivo experiments, biological impact these on proliferation, migration,...
A new approach for fabricating a layer-by-layer polymer film was explored, which based on the halogen bonding between poly(4-(4-iodo-2,3,5,6-tetrafluorophenoxy)-butyl acrylate) and poly(4-vinylpyridine). Layer-by-layer assembly of two polymers confirmed by UV-vis spectroscopy quartz crystal microbalance measurements. The interaction identified as X-ray photoelectron spectroscopy. surface multilayer is flat, thickness one bilayer about 1.3 nm. We also compared stability halogen-bonded in...
We reported a way to fabricate microporous films by post-base treatment of hydrogen-bonding-directed multilayer poly(4-vinylpyridine) (PVP) and carboxyl-terminated polyether dendrimer (DEN−COOH). The PVP/DEN−COOH film was fabricated layer-by-layer assembly PVP DEN−COOH from methanol solution. UV−visible spectroscopy revealed uniform deposition process. interaction between identified as hydrogen bonding through Fourier transform infrared (FT-IR) spectroscopy. Meanwhile, the composition change...
Four new euphane-type triterpenes, kansenone (1), kansenonol (3), 11-oxo-kansenonol (4), kansenol (5), and a tirucallane-type triterpene, epi-kansenone (2), were isolated from 60% EtOH extract of Euphorbia kansui, together with α-euphol. Their structures elucidated on the basis extensive analysis their 1D 2D NMR spectral data. This appears to be first report natural occurrence euphane/tirucallane-type triterpenes ketone at C-7. In vitro treatment cultured individual Xenopus laevis cells...
Renal interstitial fibrosis is a common pathway for the progression of chronic kidney disease (CKD) to end-stage renal disease. Renalase, acting as signaling molecule, has been reported have cardiovascular and protective effects. However, its role in remains unknown. In this study, we evaluated therapeutic efficacy renalase rats with complete unilateral ureteral obstruction (UUO) examined inhibitory effects on transforming growth factor-β1 (TGF-β1)-induced epithelial–mesenchymal transition...
Abstract Background The functions of HULC have been demonstrated in several cancers. However, its mechanism has not elucidated human liver cancer stem cells. Methods Liver cells were isolated from Huh7 cells; gene infection and tumorigenesis test vitro vivo performed. Results We demonstrate that promotes growth . Mechanistically, enhances the expression Sirt1 dependent on miR675 then induces cellular autophagy through Sirt1. CyclinD1 thereby increases pRB inhibited P21 WAF1/CIP 1 via...
Abstract Objectives Circular RNAs (circRNAs) are essential participants in tumour progression. This study focused on investigating the mechanism of a novel functional circRNA gastric cancer (GC). Methods Gene expression was detected by qRT‐PCR or Western blot. Survival curves were generated via Kaplan‐Meier method. In vitro and vivo assays used to investigate impact circ_SMAD4 GC cell growth tumorigenesis. Agarose gel electrophoresis assay, RNase R treatment Sanger sequencing utilized for...
Hepatocellular carcinoma (HCC) is highly malignant; nearly half of the new cases and deaths are in China. The poor prognosis HCC mainly due to late diagnosis; many biomarkers have been developed for diagnosis. However, few markers quickly translated into clinical practice; early differential diagnosis from cirrhosis and/or hepatitis still a challenge. Metabolomics biochemical methods were used reveal specific serum HCC. Most elevated metabolites HBV patients overlapped compared with...
Abstract Early embryos undergo extensive epigenetic reprogramming to achieve gamete‐to‐embryo transition, which involves the loading and removal of histone variant H2A.Z on chromatin. However, how does regulate gene expression modifications during preimplantation development remains unrevealed. Here, by using ultra‐low‐input native chromatin immunoprecipitation sequencing, genome‐wide distribution is delineated in mouse oocytes early embryos. These landscapes indicate that paternal removed...
Exosomes are small extracellular vesicles secreted by cells, ranging in size from 30 to 150 nm. They contain proteins, nucleic acids, lipids, and other bioactive molecules, which play a crucial role intercellular communication material transfer. In tumor immunity, exosomes present various functions while the following two of great importance: regulating immune response serving as delivery carriers. This review starts with introduction formation, compositions, functions, isolation,...
Background: Elevated estrogen has been found to contribute the pathological development of endometrial cancer (EC), potentially through alterations in tumor inflammatory immune microenvironment. However, exact mechanisms underlying this process remain unclear. Methods: Bioinformatics was used identify differentially expressed genes, analyze pathway enrichment, and assess their correlation with cell infiltration. Ishikawa cells ECC-1 were stimulated estradiol (E2) or selective receptor...
<title>Abstract</title> Photothermal therapy (PTT) has been an attractive tumor treatment strategy in recent years. Two-dimensional molybdenum disulfide (MoS<sub>2</sub>)-based nanomaterials with high photothermal efficiency is a critical candidate for PTT. However, the tumor-targeting capability extremely needs to be improved effective treatment. In this work, we combine MoS<sub>2</sub> nanodots exosomes, native vesicles secreted from living cells, construct novel exosomes/MoS<sub>2</sub>...
Asymmetric dimethylarginine (ADMA) is considered an independent mortality and cardiovascular risk factor in chronic kidney disease (CKD) patients, contributes to the development of renal fibrosis. Quercetin (QC), a natural component foods, protects against injury. Here, we explored possible mechanisms that are responsible for ADMA-induced fibrosis protective effect QC. We found ADMA treatment activated endoplasmic reticulum (ER) stress sensor proteins phosphorylated protein kinase...
Circular RNA (CircRNA) is a newly identified special class of non-coding (ncRNA) that plays an important regulatory role in the progression certain diseases. Herein, our results indicate CircMEG3 downregulated expression and negatively correlated with telomerase-related gene Cbf5 human liver cancer. Moreover, inhibits growth cancer stem cells vivo vitro. m6A methyltransferase METTL3 dependent on HULC. Cbf5, component telomere synthetase H/ACA ribonucleoprotein (RNP; catalyst pseudouracil...