A5101843738- MicroRNA in disease regulation
- Circular RNAs in diseases
- Bladder and Urothelial Cancer Treatments
- interferon and immune responses
- Chronic Kidney Disease and Diabetes
- RNA Interference and Gene Delivery
- Microbial metabolism and enzyme function
- Animal Virus Infections Studies
- Cancer-related molecular mechanisms research
- Urinary and Genital Oncology Studies
- Microbial Community Ecology and Physiology
- RNA Research and Splicing
- RNA modifications and cancer
- Advanced Glycation End Products research
- Protist diversity and phylogeny
- Cancer Immunotherapy and Biomarkers
- Bone health and treatments
- Phosphorus and nutrient management
- Viral gastroenteritis research and epidemiology
- Heme Oxygenase-1 and Carbon Monoxide
- Virology and Viral Diseases
- Gastrointestinal Tumor Research and Treatment
- Glutathione Transferases and Polymorphisms
- Extracellular vesicles in disease
- Marine Toxins and Detection Methods
Kaohsiung Medical University
2021-2025
Kaohsiung Medical University Chung-Ho Memorial Hospital
2021-2025
Capital Medical University
2016-2024
Tsinghua–Berkeley Shenzhen Institute
2024
Beijing Friendship Hospital
2016-2024
Tsinghua University
2024
Harbin Normal University
2021-2023
Lifespan
2021
Providence College
2021
Cancer Institute (WIA)
2019
Renal interstitial fibrosis is a common pathway for the progression of chronic kidney disease (CKD) to end-stage renal disease. Renalase, acting as signaling molecule, has been reported have cardiovascular and protective effects. However, its role in remains unknown. In this study, we evaluated therapeutic efficacy renalase rats with complete unilateral ureteral obstruction (UUO) examined inhibitory effects on transforming growth factor-β1 (TGF-β1)-induced epithelial–mesenchymal transition...
The objective of the present study was to evaluate impact dialysis on patients with upper tract urothelial carcinoma (UTUC) who are undergoing surgical intervention, as well identify predictive factors linked contralateral recurrence. A retrospective review conducted underwent radical nephroureterectomy (RNU) for non-metastatic UTUC at our institution from 2000 2013. recurrence rate calculated using Kaplan-Meier method, and multivariate logistic regression analysis employed examine...
We determined the effect of indoxyl sulfate (IS) on Pit-1 expression and role in IS-induced osteoblastic differentiation calcification vascular smooth muscle cells (VSMCs). To assess expression, VSMCs were incubated with various concentrations IS for different durations. Phosphonoformic acid (PFA), a competitive inhibitor Pit-1, was used to verify Pit-1. Western blot analysis quantitative real-time polymerase chain reaction (PCR) performed protein mRNA levels, respectively. evaluate...
4005 Background: Recent transformative studies in the treatment of EAC support adjuvant nivolumab for patients with residual disease following neoadjuvant chemoradiotherapy (CRT) (Checkmate 577) and pembrolizumab (P) chemotherapy untreated metastatic (Keynote 590). We hypothesized that pre-operative P combined CRT can further improve outcomes locally advanced EAC. Methods: Patients cT3-4Nx or T2N1 M0 gastroesophageal junction (GEJ) adenocarcinoma eligible curative surgery were randomized...
A Gram-negative, aerobic, non-motile, non-spore-forming and rod-shaped bacterium, named strain LZ-16-2T, was isolated from the phycosphere microbiota of paralytic shellfish poisoning toxin-producing marine dinoflagellate Alexandrium catenella LZT09. Strain LZ-16-2T grew optimally at 28 °C pH 6.5 with 3 % (w/v) NaCl. Phylogenetic analysis based on 16S rRNA gene sequence revealed that fell within genus Haliea most closely related to salexigens DSM 19537T, which new isolate exhibited 98.5...
Background: Treating renal fibrosis is crucial to delaying chronic kidney disease. The glycogen synthase kinase-3β (GSK-3β)/Snail pathway regulates and Renalase can ameliorate interstitial fibrosis. However, it not clear whether GSK-3β/Snail signaling affects action. Here, we explored the role mechanism of in anti-fibrosis action Renalase. Materials methods: We used mice with complete unilateral ureteral obstruction (UUO) human proximal tubular epithelial (HK-2) cells transforming growth...
A novel short-rod-shaped bacterial strain with poly-β-hydroxybutyric acid granules inside, designated as Z7-4T, was isolated from a culture of marine dinoflagellate palytoxin-producing capacity, Ostreopsis lenticularis OS06, collected the East China Sea. Cells Z7-4T were Gram-stain-negative, non-motile, strictly aerobic, 0.9-1.2 µm wide and 2.0-3.9 long. Growth occurred in 1-4 % (w/v) NaCl, at 15-37 °C pH 5.0-10.0, optimum growth 3.5 30 7.0. Analysis 16S rRNA gene sequence revealed that...
Abstract C1q/tumor necrosis factor‐related protein‐3 (CTRP3) has been extensively reported as an important role involved in antifibrosis, antiapoptosis, and anti‐inflammation. However, the of CTRP3 renal fibrosis remains unclear. Our current study explored its underlying mechanisms by using serums biopsy specimens from patients control subjects, rats models with surgery unilateral ureteral obstruction (UUO) human proximal tubular epithelial cells (HRPTEpiCs). We found that circulating levels...
MiR-155 and CTLA-4 are important factors involved in the regulation of immune function. However, there is no report about their involvement function stress-induced immunosuppression affecting response. In this study, chicken model response (simulation with dexamethasone immunization Newcastle disease virus (NDV) attenuated vaccine) was established, then expression characteristics miR-155 gene were analyzed at several key time points during processes NDV vaccine serum tissue levels. The...
Adipose tissue (AT) is considered as a regional immune organ and plays an important role in the anti-infection response. However, function mechanism of chicken AT response to secondary remain poorly understood. Here, we used mRNA microRNA (miRNA) sequencing technology survey transcriptomic landscape abdominal adipose (AAT) during first second immunization with Newcastle disease virus (NDV) vaccine, carried out bioinformatics analysis, such Gene Ontology (GO) terms Kyoto Encyclopedia Genes...
Upper tract urothelial carcinoma (UTUC) is a rare tumor with an incidence that varies greatly between Eastern and Western countries. Transaldolase 1 (TALDO1) rate-limiting enzyme of the pentose phosphate pathway. In humans, aberrant TALDO1 activity has been implicated in various autoimmune diseases malignancies; however, function UTUC not previously investigated. Here we evaluated clinical significance expression 115 paraffin-embedded samples from patients using immunohistochemistry. Our...
Cardiovascular disease is the leading cause of death in patients with chronic kidney disease, so there an urgent need to identify therapeutic targets control progression cardiovascular disease. Apoptosis aortic smooth muscle cells can promote but role parathyroid hormone (PTH) and sirtuin 1 pathophysiology apoptosis still unclear.Cultured human (HASMCs) were stimulated 10-6, 10-8, or 10-10 mol/L PTH for different days, was measured by flow cytometry Bcl-2 protein levels cell extracts...
MicroRNAs are a class of evolutionary conserved non-coding small RNAs that play key regulatory roles at the post-transcriptional level. In recent years, studies have shown miR-214 plays an important role in regulating several biological processes such as cell proliferation and differentiation, tumorigenesis, inflammation immunity, it has become hotspot miRNA field. this review, functions proliferation, differentiation functional activities immune-related cells, dendritic T cells NK were...
To investigate the effects of whey protein concentrate (WPC) on antioxidant statuses and lymphocyte subpopulations in rats with alcohol intake, peripheral blood (PB) PB, spleen, bone marrow (BM) fed WPC (0.334 g/kg) (6 for 3 months were analyzed. Results showed that glutathione peroxidase T B cells BM more apparent intake; however, they are not controls. Taken together, our results indicated immunity might be enhanced by increased ability after supplementation mainly spleen PB.
Little is known regarding the molecular characterization of upper tract urothelial carcinoma (UTUC). Novel therapeutic targets and prognostic predictors are imminent. In present study, we aim to examine oncogenic function mechanism Derlin-1 in UTUC. overexpression significantly associated with poor prognosis patients vitro, knockdown or over-expression markedly regulated UTUC cell invasion migration. We further discovered miR-375-3p suppresses migration by inversely regulating blocking EMT...
Studies have shown that circulating microRNAs (miRNAs) are important players in the immune response and stress-induced immunosuppression. However, function mechanism of immunosuppression affecting to Newcastle disease virus (NDV) vaccine remain largely unknown. This study analyzed changes 15 NDV-related miRNAs at different stages by qRT-PCR, aiming explore key timepoints, potential biomarkers, mechanisms for functional regulation candidate under immunosuppressed conditions. The results...
The rapidly growing demand for lithium iron phosphate (LiFePO4) as the cathode material of lithium–ion batteries (LIBs) has aggravated scarcity phosphorus (P) reserves on Earth. This study introduces an environmentally friendly and economical method P recovery from municipal wastewater, providing source LiFePO4 cathodes. novel approach utilizes sludge Fe-coagulant-based chemical removal (CPR) in wastewater treatment. After a sintering treatment with acid washing, CPR sludge, enriched Fe,...
Diabetic nephropathy (DN) presents a significant public health challenge due to its high rate of incidence and severe consequences. Renalase has been identified as having renal-protective properties. A key contributor albuminuria in DN patients is podocyte loss. The function relation activity needs be explored further. In this study, we assessed the therapeutic efficacy by monitoring changes urine protein levels db/db mice. We also induced hyperglycemia (HG) stimulate clone 5 (MPC5) cells...