A5101920222- Cardiac electrophysiology and arrhythmias
- Ion channel regulation and function
- Luminescence and Fluorescent Materials
- Supramolecular Chemistry and Complexes
- Heart Rate Variability and Autonomic Control
- Analytical Chemistry and Chromatography
- Receptor Mechanisms and Signaling
- Molecular Sensors and Ion Detection
- Heart Failure Treatment and Management
- Cardiac Arrhythmias and Treatments
- Bone and Joint Diseases
- Atrial Fibrillation Management and Outcomes
- Parathyroid Disorders and Treatments
- Synthesis and Properties of Aromatic Compounds
- Advanced Chemical Sensor Technologies
- Surfactants and Colloidal Systems
- Cardiovascular Effects of Exercise
- Spine and Intervertebral Disc Pathology
- Autophagy in Disease and Therapy
- Functional Brain Connectivity Studies
- Insect Pheromone Research and Control
- Pregnancy-related medical research
- Synthesis of heterocyclic compounds
- Multi-Criteria Decision Making
- Neuroscience and Neuropharmacology Research
China Tobacco
2025
Huazhong University of Science and Technology
2025
Beijing Friendship Hospital
2019-2024
Capital Medical University
2019-2024
Fujian Medical University
2024
China Medical University
2024
Zhengzhou University
2023-2024
Libin Cardiovascular Institute of Alberta
2013-2021
University of Calgary
2013-2021
Third Xiangya Hospital
2020
Background: Atrial fibrillation (AF) commonly occurs in hypertension and association with elevated Ang II (angiotensin II) levels. The specific mechanisms underlying II–mediated AF are unclear, interventions to prevent the effects of lacking. NPs (natriuretic peptides), which elicit their through NP receptors, including NPR-C peptide receptor-C), cardioprotective hormones that affect cardiac structure function. Methods: This study used wild-type knockout (NPR-C −/ − ) mice investigate (3...
Atrial fibrillation (AF) is prevalent in diabetes mellitus (DM); however, the basis for this unknown. This study investigated AF susceptibility and atrial electrophysiology type 1 diabetic Akita mice using vivo intracardiac electrophysiology, high-resolution optical mapping preparations, patch clamping isolated myocytes. qPCR western blotting were used to assess ion channel expression. highly susceptible association with increased P-wave duration slowed conduction velocity. In a second model...
// Feng Wang 1,* , Peipei Yin Ye Lu 1 Zubin Zhou Chaolai Jiang Yingjie Liu and Xiaowei Yu Department of Orthopaedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China * These authors contributed equally to this work should be considered as equal first coauthors Correspondence to: Yu, email: Keywords : cordycepin, osteoprotection, oxidative stress, Wnt pathway, Pathology Section Received August 06, 2015 Accepted September 28, Published October 10,...
Constructing chiral supramolecular assembly and exploring the underlying mechanism are of great significance in promoting development circularly polarized luminescence (CPL)-active materials. Herein, we report a solvation-mediated self-assembly from single-crystals to helical nanofibers based on first protic acyclic (methoxy)(amino)carbenes (pAMACs) AuI -enantiomers driven by synergetic aurophilic interactions H-bonds. Their aggregation-dependent thermally activated delayed fluorescence...
Abstract A new catalytic CC bond‐forming reaction has been developed. Catalyzed by cheap and commercially available copper(II) bromide (CuBr 2 ; 10 mol%), the reactions of α‐electron‐withdrawing group (EWG)‐substituted ketene S,S ‐acetals with aldehydes or ketones in acetonitrile at room temperature gave a variety densely functionalized coupling products excellent yields (80–98%). Based on this process, coumarin derivatives were efficiently synthesized when salicylaldehydes selected as...
Sinoatrial node (SAN) disease mechanisms are poorly understood, and therapeutic options limited. Natriuretic peptide(s) (NP) cardioprotective hormones whose effects can be mediated partly by the NP receptor C (NPR-C). We investigated role of NPR-C in angiotensin II (Ang II)-mediated SAN mice. Ang caused due to impaired electrical activity myocytes increased fibrosis. Strikingly, treatment NPR-C-/- mice worsened disease, whereas co-treatment wild-type with a selective agonist (cANF) prevented...
Background: Ten new sesquiterpenes, including eight eremophilane-type sesquiterpenes (1–8) and two compounds (9–10) with a cyclopentane ring, representing an undescribed subtype of sesquiterpene, along abietane-type diterpenoid (11), were isolated identified from deep-sea-derived fungus: Eutypella sp. Methods: Their structures elucidated on the basis various spectroscopic analyses, mainly nuclear magnetic resonance (NMR) high-resolution electrospray ionization mass spectrometry (HRESIMS)...
139 Background: C may enhance response to immune checkpoint inhibitors by promoting an immune-permissive microenvironment. COSMIC-021 (NCT03170960), a multinational phase 1b study, is evaluating the combination of with A in various solid tumors. We report interim results from Cohort 6 mCRPC. Methods: Eligible pts were required have radiographic progression soft tissue after enzalutamide and/or abiraterone, measurable disease, and ECOG PS 0 or 1. Prior chemotherapy for mCSPC was permitted....
Abstract Aims Heart rate (HR) is a critical indicator of cardiac performance that determined by sinoatrial node (SAN) function and regulation. Natriuretic peptides, including C-type NP (CNP), have been shown to modulate ion channel in the SAN when applied exogenously. CNP only acts as ligand for natriuretic peptide receptor-B (NPR-B). Despite these properties, ability NPR-B regulate HR intrinsic automaticity vivo, mechanisms which it does so, are incompletely understood. Thus, objective this...
A number of calmodulin (CaM) mutations cause severe cardiac arrhythmias, but their arrhythmogenic mechanisms are unclear. While some the CaM have been shown to impair CaM‐dependent inhibition intracellular Ca 2+ release through ryanodine receptor type 2 (RyR2), impact a majority these on RyR2 function is unknown. Here, we investigated effect 14 inhibition. We found that all tested diminished RyR2‐mediated and increased store‐overload induced (SOICR) in HEK293 cells. Moreover, either failed...
Vascular calcification (VC) is highly prevalent in patients undergoing hemodialysis, and a significant contributor to the mortality rate. Therefore, biomarkers that can accurately predict onset of VC are urgently required. Our study aimed investigate serum miR-15a levels relation develop predictive model for hemodialysis at Beijing Friendship Hospital center between 1 January 2019 31 December 2020. The were categorized into two groups: non-VC. Logistic regression (LR) models used examine...
The simplification of data processing is the frontier domain for electronic nose (e-nose) applications, whereas there are a lot manual operations in traditional procedure. To solve this problem, we propose novel method using bio-inspired neural network modeled on mammalian olfactory system. Through coding scheme with multiple squared cosine receptive fields, continuous sensor simplified as spike pattern virtual receptor units. biologically plausible bulb, which mimics structure and function...
Biological robot is one of the most popular topics in world recent years. It designed on basic electrophysiological and stimulating brain nuclei to control biological behavior movement animals. The researches aquatic bio-robot are gaps field China, so we did research controlling adult carps(n=20). carps were done craniotomy by anesthetics which eugenol was mixed with ethanol absolute at proportion 1:8 this study, electrodes stainless steel acupuncture needles 0.16 mm diameter implanted into...
Abstract Two macrocyclic bis-benzimidazolium salts 2 and 4 (23-membered for 25-membered 4) were prepared, their structures confirmed by X-ray crystallography, 1 H NMR 13 C spectroscopy. The research of anion recognitions using or as hosts carried out with the methods fluorescence ultraviolet spectroscopy, titrations, MS IR spectra. experiment results show that can detect acetate nitrate favorable selectivity sensitivity.
Two bis-imidazolium salts 1,8-bis[2'-(N-R-imidazoliumyl)acetylamino]naphthalene chloride (L1H4·Cl2: R = Et; L2H4·Cl2: nBu), as well their four NHC metal complexes [L1H2Ag]Cl (1), [L1Ni] (2), [L2Ni] (3) and [L1H2Hg(HgCl4)] (4) have been synthesized. In each of the cationic moieties 1 or 4, there is a groove-like 14-membered macrometallocycle, macrometallocycle consisted one biscarbene ligand L1H2 ion (silver(I) for mercury(II) 4). Three 6-membered cycles are contained in molecule 2 3....
Cardiovascular disease is the leading cause of death in patients with chronic kidney disease, so there an urgent need to identify therapeutic targets control progression cardiovascular disease. Apoptosis aortic smooth muscle cells can promote but role parathyroid hormone (PTH) and sirtuin 1 pathophysiology apoptosis still unclear.Cultured human (HASMCs) were stimulated 10-6, 10-8, or 10-10 mol/L PTH for different days, was measured by flow cytometry Bcl-2 protein levels cell extracts...
Recent studies have shown that
Vascular calcification is one of the most common complications chronic kidney disease (CKD), which closely associated with increased mortality and morbidity rates CKD patients. It has been reported that parathyroid hormone (PTH) aggravates vascular in However, direct role PTH smooth muscle cells (VSMCs) less elucidated. Here, we present evidence promotes apoptosis VSMCs endoplasmic reticulum (ER) stress participates this process. Human aorta (HASMCs) were treated different concentrations for...
In A7r5 smooth muscle cells, vasopressin stimulates release of Ca2+ from intracellular stores and entry, it inhibits adenylyl cyclase (AC) activity. Inhibition AC is prevented by inhibition phospholipase C or when the increase in cytosolic [Ca2+] buffer, BAPTA. It unaffected pertussis toxin, protein kinase C, L-type channels removal extracellular Ca2+. The independence occurs despite persisting for at least 15 min, whereas returns to its basal level within 1–2 min Ca2+-free medium. Although...