A5102897629- Bladder and Urothelial Cancer Treatments
- Antibiotic Resistance in Bacteria
- Epigenetics and DNA Methylation
- Urinary and Genital Oncology Studies
- Enterobacteriaceae and Cronobacter Research
- Escherichia coli research studies
- Salmonella and Campylobacter epidemiology
- Viral Infections and Vectors
- Vector-borne infectious diseases
- Adipokines, Inflammation, and Metabolic Diseases
- Cancer, Lipids, and Metabolism
- Antibiotics Pharmacokinetics and Efficacy
- MicroRNA in disease regulation
- Cancer-related Molecular Pathways
- Cancer Research and Treatments
- Peptidase Inhibition and Analysis
- Cancer-related molecular mechanisms research
- Estrogen and related hormone effects
- Mosquito-borne diseases and control
- Ferroptosis and cancer prognosis
- Molecular Biology Techniques and Applications
- Bone and Dental Protein Studies
- Telomeres, Telomerase, and Senescence
- Tannin, Tannase and Anticancer Activities
- Infectious Disease Case Reports and Treatments
Kaohsiung Medical University
2010-2023
National Yang Ming Chiao Tung University
2009-2015
I-Shou University
2009-2015
E-Da Hospital
2015
National Pingtung University of Science and Technology
2015
National Taipei University
2015
Czech Academy of Sciences, Institute of Microbiology
2010
Ministry of Health and Welfare
2000
No AccessJournal of UrologyINVESTIGATIVE UROLOGY1 Aug 2003Genetic Alterations p16INK4a and p14ARF Genes in Human Bladder Cancer LIN-LI CHANG, WEN-TING YEH, SHU-YUAN YANG, WEN-JENG WU, CHUN-HSIUNG HUANG CHANGLIN-LI CHANG Financial interest and/or other relationship with National Science Council. More articles by this author , YEHWEN-TING YEH YANGSHU-YUAN YANG WUWEN-JENG WU HUANGCHUN-HSIUNG View All Author Informationhttps://doi.org/10.1097/01.ju.0000067626.37837.3eAboutFull TextPDF ToolsAdd...
This study analysed the presence, location and transferability of integrons antibiotic resistance genes in 103 Shigella sonnei outbreak isolates 32 sporadic from Taiwan. Multiple antimicrobial was common both (95 %) (97 isolates. Class 1 were present 34 (33 six (19 %). is first, to our knowledge, identify an atypical sul3-associated class integron carrying estX-psp-aadA2-cmlA-aadA1-qacH cassette array Shigella. 2 dfr1-sat2-aadA1 predominant (90 but not Other associated with found encode...
Background Despite increased identification of spotted fever group rickettsioses (SFGR) in animals and arthropods, human SFGR are poorly characterized Taiwan. Methods Patients with suspected Q fever, scrub typhus, murine leptospirosis, dengue from April 2004 to December 2009 were retrospectively investigated for antibodies (Abs). Sera screened Rickettsia rickettsii Abs by indirect immunofluorescence antibody assay (IFA), those positive results further examined against R. rickettsii, typhi,...
ADP-ribosylation factor 6 (ARF6) is a well-studied protein that involved in multiple biological functions including cell migration and invasion. The mechanism by which ARF6 regulates the invasion of upper tract urothelial carcinoma (UTUC) still unknown. MiR-145-5p tumor suppressor microRNA, downregulated several cancer types. We aimed to elucidate molecular underlying regulation miR-145-5p UTUC. expression was observed be higher UTUC tissues than paired adjacent normal tissues. A reverse...
This study characterized class 1 integrons in Escherichia coli Taiwan. The stability and changes gene cassettes inserted into were also evaluated. included 436 clinical strains of E. isolated 2002. Class by polymerase chain reaction direct sequencing. Genetic localization was determined conjugal transfer Southern hybridization. results indicated that 64% isolates carried integrons. Molecular analysis revealed the harbored 13 different antimicrobial resistance two unknown cassettes;...
Alcoholic liver disease (ALD) continues to be a major cause of liver-related morbidity and mortality worldwide. To date, no zebrafish animal model has demonstrated the characteristic manifestations ALD in setting chronic alcohol exposure. The aim this study was develop for ALD. Male adult were housed 1% (v/v) ethanol solution up 3 months. A histopathological showed features alcoholic steatosis steatohepatitis early stages exposure, including fat droplet accumulation, ballooning degeneration...
Background and Objectives Urothelial carcinomas (UC) of urinary bladder (UB) upper tract (UT) are heterogeneous diseases with high morbidity mortality. We looked for genes metalloendopeptidase activity in a published UBUC transcriptomic database (GSE31684): MMP‐11 was the most significant, showing stepwise up‐regulation. analyzed expression association clinicopathologic factors survival our well‐characterized cohort UCs. Methods determined 295 UBUCs 340 UTUCs immunohistochemistry, evaluated...
To compare the predictive value for 5-year survival of demographic characteristics, pathological grade and stage between upper tract urothelial carcinoma (UTUC) renal pelvis (RPUC) ureter (UUC) in a Taiwanese population.In this study (1986-98) we analysed 141 patients with UTUC, including 71 RPUC 70 UUC (median age 59 years; median follow-up 54 months, SD 2.5). Prognostic indicators were examined by univariate multivariate logistic regression analyses.A significant percentage had tumour on...
OBJECTIVE To examine the hypothesis that nuclear factor‐κB (NF‐κB), a transcription factor involved in anti‐apoptosis, invasion, and angiogenesis, plays role carcinogenesis of upper urinary tract urothelial carcinoma (UUT‐UC) has prognostic value for survival. PATIENTS AND METHODS In all, 90 patients with UUT‐UC [mean (range) age, 64.5 (24–84) years] who underwent surgery at our institution from January 1991 to December 2005 were included. Clinicopathological data collected retrospectively....
OBJECTIVE To investigate the possible correlations among eNOS G894T polymorphism, erectile dysfunction (ED) and related risk factors in a Taiwanese population. MATERIALS AND METHODS In all, 151 patients with ED 77 healthy controls were enrolled. All men had complete clinical history taken laboratory data was collected. assess conditions five‐item version of International Index Erectile Function (IIEF‐5) used. The polymorphisms determined using polymerase chain reaction‐restriction fragment...
AbstractAbstractDNA sequencing and real-time PCR were used to evaluate the gyrA parC mutations, AcrAB efflux pump over-expression, their correlation with high-level resistance fluoroquinolones in 74 fluoroquinolone-resistant clinical Escherichia coli isolates recently collected Taiwan. RAPD analysis revealed high clonal diversity. Isolates four five mutations (especially Ser83Leu, Asp87Asn [or Asp87Tyr], Ala93Thr Ser80Ile Glu84Gly parC) had increased levels. The acrA gene was over-expressed...
Fifty-eight isolates of Shigella sonnei from three outbreaks in school children and eight control epidemiologically unrelated sporadic clinical infections Taiwan were compared by antibiotic susceptibility testing molecular typing. Antibiotic showed that all strains except one isolate multi-resistant. Ribotyping after restriction endonuclease digestion with SalI, PvuII HindII generated the same ribosomal pattern 65 66 isolates. Plasmid profile analysis pulsed-field gel electrophoresis (PFGE)...
Abstract Acute Q fever and scrub typhus are zoonoses endemic to southern Taiwan. Among the 137 patients with acute (89, 65.0%) or (43, 31.4%), we identified 5 (3.6%) who were co-infected Coxiella burnetii Orientia tsutsugamushi.
Colony-stimulating factor-1 (CSF-1) is a homodimeric glycoprotein. The main role of CSF-1 as hematopoietic growth factor that modulates proliferation, differentiation, and survival macrophages. Moreover, has also been reported to be aberrantly expressed in several human cancers. However, the precise upper tract urothelial carcinomas (UTUC) not studied. In this research, we examined clinical significance expression UTUC. One hundred twelve cancer tissue samples UTUC from patients were...
Upper tract urothelial carcinoma (UTUC) is a rare tumor with an incidence that varies greatly between Eastern and Western countries. Transaldolase 1 (TALDO1) rate-limiting enzyme of the pentose phosphate pathway. In humans, aberrant TALDO1 activity has been implicated in various autoimmune diseases malignancies; however, function UTUC not previously investigated. Here we evaluated clinical significance expression 115 paraffin-embedded samples from patients using immunohistochemistry. Our...
Abstract In Taiwan, Q fever cases in humans began increasing 2004 and peaked 2007 but dramatically declined 2008 2011. Cases were significantly correlated with the number of goats. The decline might be associated collateral effects measures to control goat pox 2010.
To evaluate the optimal intervention point of a selective cyclooxygenase-2 (COX-2) inhibitor, Celecoxib, for inhibiting Helicobacter pylori (H )-associated gastric carcinogenesis in Mongolian gerbils (MGs).
We analyzed the replicon types, sizes, and restriction fragment length polymorphism (RFLP) typing of plasmids carrying extended-spectrum β-lactamase (ESBL) genes in Klebsiella pneumoniae isolates from Taiwan. Fifty-one Escherichia coli transconjugant strains with ESBL-producing K. Taiwan Surveillance Antimicrobial Resistance III Program 2002 were included. All 51 carried a blaCTX-M gene, majority which blaCTX-M-3 (28/51 [54.9%]). Plasmids ranged size 126 to 241 kb by S1 nuclease digestion...